Dr. Greene received his medical degree in urologic training at the University of Dalhousie, University in Halifax, Nova Scotia.  Following postgraduate education, he went to MD Anderson to complete a three-year Fellowship in Urologic Oncology in Houston, Texas.

He was recruited to UAMS to build the section of Urologic Oncology in 1997.  He has been an active member within the College of Medicine and the Winthrop P. Rockefeller Cancer Institute.  His efforts in community outreach lead to the founding of the Arkansas Prostate Cancer Foundation in 1999 and state-appropriation for prostate cancer screening and awareness in 2001.  He was awarded the Robert Woods Bass Chair in Urologic Oncology in 2005 and made Director of the Center for Prostate Cancer Research.

While a primary focus of Dr. Greene was to improve the quality of prostate cancer treatment, his other clinical areas of expertise are in testis cancer, bladder cancer and urinary diversion and advanced renal cell carcinoma.

His basic science interests include carotenoid metabolism in prostate cancer risk, oxidative stress and mutagenesis and the epi-genetics of prostate cancer.