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- Questions About Raises, Shuttle Fees Top Administrators Forum
A UAMS Update article about Meet Your Administrator”
- Gruenwald Is New U.S. Citizen
Michael Gruenwald becomes U.S. citizen
- Gruenwald Is New U.S. Citizen
Michael Gruenwald becomes U.S. citizen
- Doughnut Sale to Help UAMS Psychiatry Youth Program
A UAMS Update article about a bake sale
- Call-in Announcements, Forums Will Give Employees More Information
A UAMS Update article about plans to improve communication between administration and employees of UAMS Medical Center
- IT Help Desk 400,000th Call Sweepstakes
IT Help Desk 400,000th Call Sweepstates
- The UAMS Help Desk Today - Ten Years Later
The UAMS Help Desk Today - Ten Years Later
- Free Tickets for UAMS Nights at Ray Winder Field
A UAMS Update article about UAMS Night with the Travelers
- ARIA Training Sessions May 19 - June 27 at UAMS
A UAMS Update article about May 19 - June 27 training sessions
- Human Research Forum Is May 21
A UAMS Update article about human research Q & A
- Accolades, May 2003
Accolades to UAMS faculty and staff
- GCRC Deadline Changed to July 1 for Grant Proposals
A UAMS Update article about GCRC pilot grants
- History of the Help Desk
- Watch, Look & Listen: Preview of New UAMS Public Service Campaign
- Forum to Discuss Impact of HIPAA on Research
Update article about HIPAA and research at UAMS
- Human Research Q and A Forum June 27
A UAMS Update article about the human research forum
- Emailed Version of UAMS Notice of Privacy Practices
UAMS Notice of Privacy Practices
- Free UAF Symposium Aug. 14-15 on Evolution of Human Diet
A UAMS Update article about a diet symposium at UAF
- Tom Butler is Arkansas Administrator of the Year
Tom Butler of UAMS Is Arkansas Administrator of the Year
- Join the Prostate Cancer Race Walk. Click Here for Registration Form.*
Join the Prostate Cancer Race Walk. Click Here for Registration Form.
- Join the Prostate Cancer Race Walk. Click Here for Registration Form.*
Join the Prostate Cancer Race Walk. Click Here for Registration Form.
- Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
- Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
- Join UAMS/ACRC Team in Race for the Cure®!
Join UAMS/ACRC Team in Race for the Cure!
- Join UAMS/ACRC Team in Race for the Cure®!
Join UAMS/ACRC Team in Race for the Cure!
- UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
- UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
- Photo Album: Stephens Institute Was a Highlight of Medicine Alumni Reunion
Photo Album: Stephens Institute Was a Highlight of Medicine Alumni Reunion
- Kids First in Fort Smith Celebrated Fourth in Style
Kids First in Fort Smith Celebrated Fourth in Style
- Class of 1948 Dedicates Endowment to Excellence in Education
Class of 1948 Dedicates Endowment to Excellence in Education
- Pharmacy Professor Elected to American College of Clinical Pharmacy
Pharmacy Professor Elected to American College of Clinical Pharmacy
- Pharmaceutical Scientists, Graduate Students Meet at UAMS
Pharmaceutical Scientists, Graduate Students Meet at UAMS
- Stephanie Gardner, Pharm.D., Ed.D., Is Interim Dean of College of Pharmacy
Stephanie Gardner, Pharm.D., Ed.D., Is Interim Dean of College of Pharmacy
- New COPH Survey Research Expert Eager to Develop New Ways of Measuring Public Health
New COPH Survey Research Expert Eager to Develop New Ways of Measuring Public Health
- Ready, Set, Go! UAMS, KATV Launch Get Healthy Arkansas™
UAMS, KATV Launch Get Healthy Arkansas™
- UAMS Faculty Members Participated in International Meeting on Biotechnology
Owens and O'Brien de-brief AR legislators on news from Biotechnology Industry Organization
- UAMS Faculty Members Participated in International Meeting on Biotechnology
Owens and O'Brien de-brief AR legislators on news from Biotechnology Industry Organization
- UAMS Receives $715,000 In Research Funds
UAMS receives $715K in research funds
- UAMS Receives $715,000 In Research Funds
UAMS receives $715K in research funds
- Nursing Researcher Selected for New York Seminar
Pao-Feng Tsai, Ph.D., RN, selected to present research at seminar in NYC
- Nursing Researcher Selected for New York Seminar
Pao-Feng Tsai, Ph.D., RN, selected to present research at seminar in NYC
- Cellular and Molecular Research: An Exciting Time To Be a Scientist (video)
UAMS and two partner campuses have received a $6 million grant for a complex project to link biomedical researchers around Arkansas.
- Cellular and Molecular Research: An Exciting Time To Be a Scientist (video)
UAMS and two partner campuses have received a $6 million grant for a complex project to link biomedical researchers around Arkansas.
- UAMS, Partners Receive $6 Million for Biomedical Research Network
UAMS and two partner campuses have received a $6 million, three-year grant to create a network of high-powered research laboratories and expand Arkansas’s biotechnology workforce.
- UAMS, Partners Receive $6 Million for Biomedical Research Network
UAMS and two partner campuses have received a $6 million, three-year grant to create a network of high-powered research laboratories and expand Arkansas’s biotechnology workforce.
- UAMS to Create Myeloma Institute
UAMS announces Myeloma Institute for Research and Therapy
- UAMS to Create Myeloma Institute
UAMS announces Myeloma Institute for Research and Therapy
- UAMS to Create Myeloma Institute
UAMS announces Myeloma Institute for Research and Therapy
- UAMS Receives $834,500 in Research Funds
UAMS receives $834.5K for medical research
- UAMS Receives $834,500 in Research Funds
UAMS receives $834.5K for medical research
- UAMS Creates Myeloma Institute (audio bites)
UAMS establishes Myeloma Institute for Research and Therapy
- UAMS Creates Myeloma Institute (audio bites)
UAMS establishes Myeloma Institute for Research and Therapy
- UAMS Cardiologist To Appear on KATV
Saucedo scheduled to appear on TV/7 to discuss his cardiac research findings.
- UAMS Cardiologist To Appear on KATV
Saucedo scheduled to appear on TV/7 to discuss his cardiac research findings.
- G. Richard Smith, M.D., Is New Chair of Psychiatry
Smith appointed chair of Department of Psychiatry and Behavioral Sciences.
- G. Richard Smith, M.D., Is New Chair of Psychiatry
Smith appointed chair of Department of Psychiatry and Behavioral Sciences.
- G. Richard Smith, M.D., Is New Chair of Psychiatry
Smith appointed chair of Department of Psychiatry and Behavioral Sciences.
- G. Richard Smith, M.D., Is New Chair of Psychiatry
Smith appointed chair of Department of Psychiatry and Behavioral Sciences.
- Students Are Partners in Research
Medical, pharmacy, and undergraduate students presented their research findings at a scientific symposium at UAMS campus.
- Students Are Partners in Research
Medical, pharmacy, and undergraduate students presented their research findings at a scientific symposium at UAMS campus.
- UAMS Receives $6,066,000 in Research Funding
Researchers at UAMS received approximately $6 million in research funding during the weeks of Aug. 27 – Sept. 14, 2001.
- UAMS Receives $6,066,000 in Research Funding
Researchers at UAMS received approximately $6 million in research funding during the weeks of Aug. 27 – Sept. 14, 2001.
- UAMS Researcher Wins Heart Association Award
Kennedy receives Worthen-Cornett Award from American Heart Association.
- UAMS Researcher Wins Heart Association Award
Kennedy receives Worthen-Cornett Award from American Heart Association.
- Donations Fund New Research Grants
The UAMS Foundation Fund Board has awarded nine internal research grants to faculty scientists; the allocations come from income from the UAMS Medical Research Endowment Fund.
- Donations Fund New Research Grants
The UAMS Foundation Fund Board has awarded nine internal research grants to faculty scientists; the allocations come from income from the UAMS Medical Research Endowment Fund.
- Clinical Research Grant Deadline Is Dec. 1, 2001
The first deadline is December 1, 2001 in a new grant program at UAMS.
- Clinical Research Grant Deadline Is Dec. 1, 2001
The first deadline is December 1, 2001 in a new grant program at UAMS.
- Cell Biology Society Selects UAMS Researcher for Prestigious Publication
The American Society for Cell Biology has included the recent work of Cynthia J.M. Kane, Ph.D., of UAMS in its Press Book 2001 - a summary of important new research in cell biology.
- Cell Biology Society Selects UAMS Researcher for Prestigious Publication
The American Society for Cell Biology has included the recent work of Cynthia J.M. Kane, Ph.D., of UAMS in its Press Book 2001 - a summary of important new research in cell biology.
- Clinical Research Grant Deadline Is December 1, 2001
The first deadline is December 1, 2001, in a new grant program at UAMS.
- Clinical Research Grant Deadline Is December 1, 2001
The first deadline is December 1, 2001, in a new grant program at UAMS.
- UAMS to Study Health Insurance Access with $1.5 Million Grant
UAMS has received $1.5 million to develop public policy recommendations on health insurance coverage for Arkansans.
- UAMS to Study Health Insurance Access with $1.5 Million Grant
UAMS has received $1.5 million to develop public policy recommendations on health insurance coverage for Arkansans.
- New High-risk OB at UAMS Observes Campus’s Unique Fetal Exam
Reece recently toured an experimental fetal monitoring facility at UAMS.
- New High-risk OB at UAMS Observes Campus’s Unique Fetal Exam
Reece recently toured an experimental fetal monitoring facility at UAMS.
- UAMS Joins Tribute to the Late Col. T. H. Barton
UAMS joined a tribute today (National Philanthropy Day) to the late Arkansas philanthropist Col. T. H. Barton of El Dorado.
- UAMS Joins Tribute to the Late Col. T. H. Barton
UAMS joined a tribute today (National Philanthropy Day) to the late Arkansas philanthropist Col. T. H. Barton of El Dorado.
- UAMS, UAF Receive $5.5 Million To Study Drug Treatment
Scientists at UAMS and UofA at Fayetteville have received $5.5 million to develop and test new medicines for methamphetamine abuse.
- UAMS, UAF Receive $5.5 Million To Study Drug Treatment
Scientists at UAMS and UofA at Fayetteville have received $5.5 million to develop and test new medicines for methamphetamine abuse.
- UAMS Biotech Efforts Are Prominent in National Report
A new national report on states' efforts to expand biotechnology gives considerable attention to Arkansas projects; including the technology “incubator” at UAMS.
- UAMS Biotech Efforts Are Prominent in National Report
A new national report on states' efforts to expand biotechnology gives considerable attention to Arkansas projects; including the technology “incubator” at UAMS.
- 50 Years of People, Progress and Promise
In its 50-year history, the Department of Psychiatry within the UAMS College of Medicine has had three chairmen. William Reese, M.D., held the title from 1951-1985; Frederick Guggenheim, M.D., chaired from 1985-2000; and in 2001, UAMS College of Medicine alum G. Richard Smith, M.D., was appointed to lead the department.
- 50 Years of People, Progress and Promise
In its 50-year history, the Department of Psychiatry within the UAMS College of Medicine has had three chairmen. William Reese, M.D., held the title from 1951-1985; Frederick Guggenheim, M.D., chaired from 1985-2000; and in 2001, UAMS College of Medicine alum G. Richard Smith, M.D., was appointed to lead the department.
- 50 Years of People, Progress and Promise
In its 50-year history, the Department of Psychiatry within the UAMS College of Medicine has had three chairmen. William Reese, M.D., held the title from 1951-1985; Frederick Guggenheim, M.D., chaired from 1985-2000; and in 2001, UAMS College of Medicine alum G. Richard Smith, M.D., was appointed to lead the department.
- 50 Years of People, Progress and Promise
In its 50-year history, the Department of Psychiatry within the UAMS College of Medicine has had three chairmen. William Reese, M.D., held the title from 1951-1985; Frederick Guggenheim, M.D., chaired from 1985-2000; and in 2001, UAMS College of Medicine alum G. Richard Smith, M.D., was appointed to lead the department.
- 50 Years of People, Progress and Promise
In its 50-year history, the Department of Psychiatry within the UAMS College of Medicine has had three chairmen. William Reese, M.D., held the title from 1951-1985; Frederick Guggenheim, M.D., chaired from 1985-2000; and in 2001, UAMS College of Medicine alum G. Richard Smith, M.D., was appointed to lead the department.
- 50 Years of People, Progress and Promise
In its 50-year history, the Department of Psychiatry within the UAMS College of Medicine has had three chairmen. William Reese, M.D., held the title from 1951-1985; Frederick Guggenheim, M.D., chaired from 1985-2000; and in 2001, UAMS College of Medicine alum G. Richard Smith, M.D., was appointed to lead the department.
- Radiology Researchers, Designer Win International Awards for Posters
Physicians and investigators at UAMS won several awards at a recent international meeting of radiologists.
- Radiology Researchers, Designer Win International Awards for Posters
Physicians and investigators at UAMS won several awards at a recent international meeting of radiologists.
- Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09)
Novel biomarker profile for the management of metastisis to bone of patients with breast cancer.
- Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09)
Novel biomarker profile for the management of metastisis to bone of patients with breast cancer.
- Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09)
Novel biomarker profile for the management of metastisis to bone of patients with breast cancer.
- Gray’s Anomaly: A Source of Empowerment
Feb. 8, 2012 | “I’ll trim it so it’s not so bulky,” James Y. Suen, M.D., said as he folded, then snipped a tiny edge of gauze off before he placed it on his patient’s right jaw. He has cared for 23-year-old Jasmine Gray ever since she was 11 when she traveled from Memphis, Tenn. to see him after first being misdiagnosed.
- Need Something Sweet for Your Valentine?
Need Something Sweet for Your Valentine?
- Need Something Sweet for Your Valentine?
Need Something Sweet for Your Valentine?
- Code Moo Now Open
Code Moo Now Open
- Code Moo Now Open
Code Moo Now Open
- Sign Up for the UAMS House of Delegates Relay for Life Team
UAMS House of Delegates Relay for Life Team
- Sign Up for the UAMS House of Delegates Relay for Life Team
UAMS House of Delegates Relay for Life Team
- Overwhelming Response to SmartCare
Overwhelming Response to SmartCare
- Overwhelming Response to SmartCare
Overwhelming Response to SmartCare
- Celebrating African American Women Firsts
Celebrating African American Women Firsts
- Celebrating African American Women Firsts
Celebrating African American Women Firsts
- Nutrition Department Hosts Food Drive
Nutrition Department Hosts Food Drive
- Nutrition Department Hosts Food Drive
Nutrition Department Hosts Food Drive
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. 11-11
Treatment of cardiovascular diseases, heart attack and stroke remain leading causes of death in the world, affecting close to 15 million individuals per year. Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. 11-11
Treatment of cardiovascular diseases, heart attack and stroke remain leading causes of death in the world, affecting close to 15 million individuals per year. Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. 11-11
Treatment of cardiovascular diseases, heart attack and stroke remain leading causes of death in the world, affecting close to 15 million individuals per year. Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
- In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
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OCT. 4, 2001 | Scientists at the University of Arkansas for Medical Sciences (UAMS) are studying why acetaminophen, an ingredient in many non-prescription medicines for pain and fever, can cause liver damage in large doses.
Understanding exactly how the drug damages the liver may help victims of acetaminophen overdose. Currently, patients who receive medical treatment 10 hours after overdosing are at higher risk of severe liver injury. Significant damage is also more common with preexisting liver disease, including alcoholics. |
Dr. James (left) and Dr. Hinson (right) recently briefed the new dean of medicine at UAMS on their research. E. Albert Reece, M.D., Ph.D., M.B.A., will become dean of the College of Medicine at UAMS full-time in January 2002. James Yu (second from left) and Tamara Knight, graduate students in interdisciplinary toxicology, helped show the research laboratory to the dean.
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Acetaminophen is one of the most frequent causes of poisoning related to a pharmaceutical products worldwide. The American Association of Poison Control Centers received reports of more than 100,000 overdoses involving acetaminophen in 1998.
Laura James, M.D., advises patients using acetaminophen to “follow the instructions on the bottle when treating yourself or your children with acetaminophen.” Parents should avoid giving children more than one producing containing acetaminophen and should use medications intended for children, not adults.
Dr. James is an assistant professor in the Department of Pediatrics in the UAMS College of Medicine. Jack Hinson, Ph.D., is a professor and director of the Division of Toxicology in the Department of Pharmacology and Toxicology in the College of Medicine.
They and other scientists at UAMS are working to determine exactly how liver cells are injured and die following overdoses of acetaminophen.
”We understand some factors in why acetaminophen is toxic, but we don’t understand other factors,” Dr. Hinson explains. “This research will help us understand cell death in the liver, which may improve treatment for acetaminophen overdoses as well as other drug-related injuries to the liver.” Drs. Hinson and James are focusing on events that occur after the toxic metabolite of acetaminophen binds to liver cells, and how these events cause liver cell death.
Several federal grants support their research. Dr. James received a Mentored Clinical Scientist Development Award from the NIH. That grant, which pays a significant portion of her salary for four years, is part of an NIH program to foster basic science research by physicians in collaboration with basic scientists. Through this award, Dr. James collaborates with Dr. Hinson and Toni Darville, M.D., an associate professor in the Departments of Pediatrics and Microbiology. Dr. James and her colleagues have had several articles about acetaminophen toxicity published in scholarly journals, including the Journal of Clinical Pharmacology, Clinical Pediatrics, and Clinical Pharmacology and Therapeutics, reporting the results of studies of acetaminophen toxicity in children and adolescents.
These studies were performed within the Network of Pediatric Pharmacology Research Units (PPRU), a consortium of 13 pediatric pharmacology research programs funded by the NIH. Tom Wells, M.D., an associate professor in the Department of Pediatrics, is the principal investigator for the PPRU at Arkansas Children's Hospital and UAMS.
In addition, Dr. Hinson and Philip R., Mayeux, Ph.D., associate professor of pharmacology and toxicology, have a research grant from the National Institutes of Health (NIH) to study the toxicity of acetaminophen. The grant will support their research for at least four years.
Links on This Page
Department of Pediatrics: http://pediatrics.ach.uams.edu/
Department of Pharmacology and Toxicology: http://www.uams.edu/pharmtox/pharmtox.htm
Pediatric Pharmacology Research Unit Network: http://www.nichd.nih.gov/crmc/eng/ped/ped2.htm
Nitric Oxide: http://www.idealibrary.com/servlet/
useragent?func=showAllIssues&curIssueID=niox | |