UAMS Laser Could Open Up World of Tiny Lymph Vessels to Scientists

UAMS Laser Could Open Up World of Tiny Lymph Vessels to Scientists
Home Questions About Raises, Shuttle Fees Top Administrators Forum A UAMS Update article about Meet Your Administrator” Gruenwald Is New U.S. Citizen Michael Gruenwald becomes U.S. citizen Gruenwald Is New U.S. Citizen Michael Gruenwald becomes U.S. citizen Doughnut Sale to Help UAMS Psychiatry Youth Program A UAMS Update article about a bake sale Call-in Announcements, Forums Will Give Employees More Information A UAMS Update article about plans to improve communication between administration and employees of UAMS Medical Center IT Help Desk 400,000th Call Sweepstakes IT Help Desk 400,000th Call Sweepstates The UAMS Help Desk Today - Ten Years Later The UAMS Help Desk Today - Ten Years Later Free Tickets for UAMS Nights at Ray Winder Field A UAMS Update article about UAMS Night with the Travelers ARIA Training Sessions May 19 - June 27 at UAMS A UAMS Update article about May 19 - June 27 training sessions Human Research Forum Is May 21 A UAMS Update article about human research Q & A Accolades, May 2003 Accolades to UAMS faculty and staff GCRC Deadline Changed to July 1 for Grant Proposals A UAMS Update article about GCRC pilot grants History of the Help Desk Watch, Look & Listen: Preview of New UAMS Public Service Campaign Forum to Discuss Impact of HIPAA on Research Update article about HIPAA and research at UAMS Human Research Q and A Forum June 27 A UAMS Update article about the human research forum Emailed Version of UAMS Notice of Privacy Practices UAMS Notice of Privacy Practices Free UAF Symposium Aug. 14-15 on Evolution of Human Diet A UAMS Update article about a diet symposium at UAF Tom Butler is Arkansas Administrator of the Year Tom Butler of UAMS Is Arkansas Administrator of the Year Join the Prostate Cancer Race Walk. Click Here for Registration Form.* Join the Prostate Cancer Race Walk. Click Here for Registration Form. Join the Prostate Cancer Race Walk. Click Here for Registration Form.* Join the Prostate Cancer Race Walk. Click Here for Registration Form. Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS Join UAMS/ACRC Team in Race for the Cure®! Join UAMS/ACRC Team in Race for the Cure! Join UAMS/ACRC Team in Race for the Cure®! Join UAMS/ACRC Team in Race for the Cure! UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test Photo Album: Stephens Institute Was a Highlight of Medicine Alumni Reunion Photo Album: Stephens Institute Was a Highlight of Medicine Alumni Reunion Kids First in Fort Smith Celebrated Fourth in Style Kids First in Fort Smith Celebrated Fourth in Style Class of 1948 Dedicates Endowment to Excellence in Education Class of 1948 Dedicates Endowment to Excellence in Education Pharmacy Professor Elected to American College of Clinical Pharmacy Pharmacy Professor Elected to American College of Clinical Pharmacy Pharmaceutical Scientists, Graduate Students Meet at UAMS Pharmaceutical Scientists, Graduate Students Meet at UAMS Stephanie Gardner, Pharm.D., Ed.D., Is Interim Dean of College of Pharmacy Stephanie Gardner, Pharm.D., Ed.D., Is Interim Dean of College of Pharmacy New COPH Survey Research Expert Eager to Develop New Ways of Measuring Public Health New COPH Survey Research Expert Eager to Develop New Ways of Measuring Public Health Ready, Set, Go! UAMS, KATV Launch Get Healthy Arkansas™ UAMS, KATV Launch Get Healthy Arkansas™ UAMS Reports Bone Loss from Oral Diabetes Drug UAMS Reports Bone Loss from Oral Diabetes Drug Of Arkansas’ “Best Doctors,” More than Half Are on UAMS Faculty Of Arkansas’ “Best Doctors,” More than Half Are on UAMS Faculty UAMS Reports in Groundbreaking Study: Women’s Unusual Fatigue, Other Symptoms Could Warn of Impending Heart Attacks LITTLE ROCK – Researchers at the University of Arkansas for Medical Sciences (UAMS) report today that women in a study who had heart attacks remembered having unusual fatigue or other new symptoms as much as a month beforehand – suggesting a new way to stop heart attacks before they happen. “New or different fatigue, sleep problems, shortness of breath, indigestion, and anxiety could be early warning signs of heart disease,” Jean C. McSweeney, Ph.D., R.N., of the UAMS College of Nursing, said. “The appearance of these new symptoms, in conjunction with women’s standard cardiovascular risk factors, should help providers recognize women who should be thoroughly checked for heart disease.” McSweeney was the lead researcher in the study which Circulation, the journal of the American Heart Association, published today. In a three-year study of women in Arkansas, North Carolina, and Ohio, the UAMS researchers found that 95 percent of women who had heart attacks remembered having new symptoms more than a month beforehand. The American Heart Association called the study, funded by the National Institute of Nursing Research, “one of the first comprehensive examinations of issues that might allow prevention of imminent heart attack in women.” The most common early symptoms that women remembered were unusual fatigue (70 percent), sleep disturbance (48 percent), shortness of breath (42 percent), indigestion (39 percent), and anxiety (35 percent). The symptoms stopped after their heart attacks. Only 30 percent of women in the survey remembered chest discomfort, which they usually described as aching, tightness, or pressure, but not pain. “Women need to understand that the appearance of new symptoms could warn of imminent heart attack or developing heart disease, especially if they have other cardiovascular risk factors such as smoking, high blood pressure, high cholesterol, diabetes, being overweight, or a family history of heart disease,” McSweeney said. In earlier studies, McSweeney and her colleagues found that women who remembered a variety of symptoms in the month before their heart attacks either ignored the signs or were misdiagnosed when they sought medical help. Women also tend to have different symptoms during heart attacks. Rather than the chest pain that men typically experience, women are more likely to have shortness of breath (58 percent), weakness (55 percent), unusual fatigue (43 percent), cold sweat (39 percent), and dizziness (39 percent). “Lack of chest pain may be a major reason why women have more unrecognized heart attacks than men or are mistakenly diagnosed and discharged from emergency departments. Many clinicians still consider chest pain the primary symptom of a heart attack,” she said. The Arkansas-North Carolina-Ohio group was primarily Caucasian, so McSweeney is now studying ethnic minorities. The other UAMS researchers on the project are Marisue Cody, Ph.D., R.N., and Patricia O’Sullivan, Ed.D. Electric Cooperatives of Arkansas continue grant to improve rural health care The Electric Cooperatives of Arkansas on Oct. 25 presented a check for $20,000 to the University of Arkansas for Medical Sciences (UAMS), continuing their support for a five-year program designed to reduce cancer incidence and mortality in rural areas of Arkansas. UAMS Receives Another $1.5 Million from Jackson T. Stephens, Plus Matching $1.5 Million from Donald W. Reynolds Foundation UAMS Receives Another $1.5 Million from Jackson T. Stephens, Plus Matching $1.5 Million from Donald W. Reynolds Foundation UAMS Cancer Researcher Obtains $1.5 Million for Study of Bone Cancer UAMS Cancer Researcher Obtains $1.5 Million for Study of Bone Cancer, LITTLE ROCK – Ralph D. Sanderson, Ph.D., of the Arkansas Cancer Research Center (ACRC), part of the University of Arkansas for Medical Sciences (UAMS), has obtained a $1.5 million grant from the National Cancer Institute for his groundbreaking work on the growth of tumor cells in bone. Sanderson will lead a team of researchers studying heparan sulfate proteoglycans, molecules made by tumor cells which can regulate the ability of the tumors to grow and metastasize. The ACRC team is investigating the processes by which heparan sulfate chains are released by an enzyme called heparanase. They believe this enzyme causes heparan sulfate to activate tumor cells and stimulatetumor metastasis to bone. Sanderson is internationally known for his research. Since he joined the UAMS faculty in 1989, he has received continuous funding for his research from the National Institutes of Health and the Arthritis Foundation. He is the Drs. Mae and Anderson Nettleship Endowed Chair in Oncologic Pathology in the UAMS College of Medicine. Thomas J. Kelly, Jr., Ph.D., an expert in degradative enzymes, and Larry J. Suva, Ph.D., an expert in bone biology, will collaborate with Sanderson. Kelly and Suva are also members of ACRC. During their five-year study, the researchers will focus on breast cancer and myeloma specifically, but their findings may be applicable to other cancers that invade and destroy the skeleton. The researchers believe their work will provide insight into the mechanistic process of tumor bone destruction, and may identify new therapeutic targets. Heparan sulfate is a carbohydrate (sugar) chain that is biologically active, binding to various “effector” molecules involved in cell signaling. Heparanase is an enzyme that will break down heparan sulfate chains into much shorter chains. That produces many more molecular chains that are still biologically active. These chains can stimulate the tumor to grow and metastasize. By preventing the breakdown of heparan sulfate, tumor growth may be inhibited. This study could help determine if any of the several heparanase inhibitors now being used in clinical trials are effective in the prevention of bone metastasis. UAMS Targets Teen Mental Illness, Substance Abuse UAMS has received the third major grant in two months to help Arkansans struggling with both substance abuse and mental health problems – this time, targeting teenagers. UAMS First in State to Offer Advanced Radiation Therapy for Prostate Cancer UAMS is first in Arkansas to offer advanced radiation therapy for Prostate Cancer Arts of UAMS Features Physician’s Watercolor Paintings Jan. 6 - Feb. 27 Arts of UAMS displays watercolor paintings by V. Gail Ray, M.D., an emergency medicine physician at UAMS UAMS Offers State’s First Program to Train Cancer Registrars UAMS ofers state’s first training program for cancer registrars Free or Low-Cost Mammograms Offered in Several Arkansas Counties, Thanks to Witness Project at UAMS Free or Low-Cost Mammograms offered in several Arkansas counties thanks to Witness Project at UAMS Brick Pavers Party Oct. 9 at UAMS Family Home Brick Pavers Party Oct. 9 at UAMS Family Home UAMS Helps Victims of Violence, Disasters LITTLE ROCK – A new program at the University of Arkansas for Medical Sciences (UAMS) can help victims of violence or disasters cope with lingering depression and anxiety. New Study Explains Why UAMS is Such a Vital Force in Arkansas’ Economy UAMS Research Shows High-carb Diet Works Without Cutting Calories UAMS Research Shows High-carb Diet Works Without Cutting Calories Sen. Lincoln, UAMS Spearhead Mid-America Genetic Counseling Consortium Sen. Lincoln, UAMS Spearhead Mid-America Genetic Counseling Consortium UAMS Discovery Enhances Safety of World’s Food Supply Safe Foods Corporation Receives FDA Approval for Cecure™ UAMS Discovery Enhances Safety of World’s Food Supply Safe Foods Corporation Receives FDA Approval for Cecure™ UAMS Receives $547,500 for Nursing Scholarships UAMS Receives $547,500 for Nursing Scholarships Arts of UAMS Features Nurse’s Photographs March 1 - April 30 Arts of UAMS Features Nurse’s Photographs March 1 - April 30 UAMS “Julep Cup Jaunt” May 1 UAMS “Julep Cup Jaunt” May 1 UAMS Honors Jeanne Heard with Bumpers Award UAMS Honors Jeanne Heard with Bumpers Award UAMS Receives $21.5 Million from Walker Foundation UAMS Receives $21.5 Million from Walker Foundation UAMS Receives $21.5 Million from Walker Foundation The Willard and Pat Walker Charitable Foundation of Springdale has given $21.5 million to the University of Arkansas for Medical Sciences (UAMS) for its eye institute, Alzheimer's disease research, and psychiatry program. Stephanie Gardner Is Named Dean of UAMS College of Pharmacy Stephanie Gardner Is Named Dean of UAMS College of Pharmacy UAMS Receives Grant to Track Arkansas Childhood Obesity Levels UAMS Receives Grant to Track Arkansas Childhood Obesity Levels UAMS Dedicates College of Public Health UAMS Dedicates College of Public Health UAMS Honors Donald E. McMillan for 26 Years of Research, Teaching UAMS Honors Donald E. McMillan for 26 Years of Research, Teaching UAMS College of Medicine Faculty Discuss Body Mass Index, Alzheimer’s Disease and Diabetes May 21 in Fort Smith UAMS College of Medicine Faculty Discuss Body Mass Index, Alzheimer’s Disease and Diabetes May 21 in Fort Smith UAMS College of Medicine Faculty Discuss Body Mass Index, Alzheimer’s Disease and Diabetes May 21 in Fort Smith UAMS College of Medicine Faculty Discuss Body Mass Index, Alzheimer’s Disease and Diabetes May 21 in Fort Smith UAMS Gynecological Oncology Director to Discuss Cervical Cancer at Free Public Lecture May 13 in Fort Smith UAMS Gynecological Oncology Director to Discuss Cervical Cancer at Free Public Lecture May 13 in Fort Smith Study Led by Scientists at UAMS/ACHRI Shows Routine Doses of Morphine for Pain Could Harm Premature Babies Brendan Stack Joins UAMS Department of Otolaryngology LITTLE ROCK – Brendan Stack Jr., M.D., has joined the University of Arkansas for Medical Sciences (UAMS) as vice chairman of the Department of Otolaryngology – Head and Neck Surgery in the College of Medicine. Brendan Stack Joins UAMS Department of Otolaryngology LITTLE ROCK – Brendan Stack Jr., M.D., has joined the University of Arkansas for Medical Sciences (UAMS) as vice chairman of the Department of Otolaryngology – Head and Neck Surgery in the College of Medicine. Brendan Stack Joins UAMS Department of Otolaryngology LITTLE ROCK – Brendan Stack Jr., M.D., has joined the University of Arkansas for Medical Sciences (UAMS) as vice chairman of the Department of Otolaryngology – Head and Neck Surgery in the College of Medicine. UAMS Cancer Control Department Awarded $60,000 Grant for Cancer Prevention Programs LITTLE ROCK – The Cancer Control Department of the Arkansas Cancer Research Center (ACRC) at the University of Arkansas for Medical Sciences (UAMS) has been awarded a grant of $60,000 by the University of Arkansas at Pine Bluff (UAPB) Minority Sub-recipient Grant Office. UAMS Cancer Control Department Awarded $60,000 Grant for Cancer Prevention Programs LITTLE ROCK – The Cancer Control Department of the Arkansas Cancer Research Center (ACRC) at the University of Arkansas for Medical Sciences (UAMS) has been awarded a grant of $60,000 by the University of Arkansas at Pine Bluff (UAPB) Minority Sub-recipient Grant Office. Center for Rural Health Presents CME/CE Lecture: "Major Depressive Disorder-Diagnosis and Treatment" Center for Rural Health Presents CME/CE Lecture: "Major Depressive Disorder-Diagnosis and Treatment" Center for Rural Health Presents CME/CE Lecture: "Major Depressive Disorder-Diagnosis and Treatment" Center for Rural Health Presents CME/CE Lecture: "Major Depressive Disorder-Diagnosis and Treatment" UAMS Hosts Monthly Nutrition Seminar Feb. 9 UAMS Hosts Monthly Nutrition Seminar Feb. 9 UAMS Hosts Monthly Nutrition Seminar Feb. 9 UAMS Hosts Monthly Nutrition Seminar Feb. 9 Enterprise Server Replacement Enterprise Server Replacement Occupational Health & Safety Survey Occupational Health & Safety Survey Occupational Health & Safety Survey Occupational Health & Safety Survey Bookstore Offers 40 Percent Discount on Russell Jerzee Apparel Bookstore Offers 40 Percent Discount on Russell Jerzee Apparel Bookstore Offers 40 Percent Discount on Russell Jerzee Apparel Bookstore Offers 40 Percent Discount on Russell Jerzee Apparel UAMS Opens Code Moo Frozen Yogurt Shop UAMS Opens Code Moo Frozen Yogurt Shop UAMS Opens Code Moo Frozen Yogurt Shop UAMS Opens Code Moo Frozen Yogurt Shop UAMS Hosts Blood Drives in COPH, Freeway Medical UAMS Hosts Blood Drives in COPH, Freeway Medical UAMS Hosts Blood Drives in COPH, Freeway Medical UAMS Hosts Blood Drives in COPH, Freeway Medical TIAA-CREF on Campus in February and March TIAA-CREF on Campus in February and March TIAA-CREF on Campus in February and March TIAA-CREF on Campus in February and March Human Resources Hosts 'HR Connects!' Feb. 16 Human Resources Hosts 'HR Connects!' Feb. 16 Human Resources Hosts 'HR Connects!' Feb. 16 Human Resources Hosts 'HR Connects!' Feb. 16 Arm protection System (APS) for robotic surgery: A surgical device to position the arms of surgical patients during prolonged robotic surgical procedures. (11-04) A device to secure and position the arms of patients during prolonged surgical procedures to protect against nerve damage and assist the anesthesiologist access to IV sites. Arm protection System (APS) for robotic surgery: A surgical device to position the arms of surgical patients during prolonged robotic surgical procedures. (11-04) A device to secure and position the arms of patients during prolonged surgical procedures to protect against nerve damage and assist the anesthesiologist access to IV sites. Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09) Novel biomarker profile for the management of metastisis to bone of patients with breast cancer. Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09) Novel biomarker profile for the management of metastisis to bone of patients with breast cancer. Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09) Novel biomarker profile for the management of metastisis to bone of patients with breast cancer. Gray’s Anomaly: A Source of Empowerment Feb. 8, 2012 \| “I’ll trim it so it’s not so bulky,” James Y. Suen, M.D., said as he folded, then snipped a tiny edge of gauze off before he placed it on his patient’s right jaw. He has cared for 23-year-old Jasmine Gray ever since she was 11 when she traveled from Memphis, Tenn. to see him after first being misdiagnosed. Need Something Sweet for Your Valentine? Need Something Sweet for Your Valentine? Need Something Sweet for Your Valentine? Need Something Sweet for Your Valentine? Code Moo Now Open Code Moo Now Open Code Moo Now Open Code Moo Now Open Sign Up for the UAMS House of Delegates Relay for Life Team UAMS House of Delegates Relay for Life Team Sign Up for the UAMS House of Delegates Relay for Life Team UAMS House of Delegates Relay for Life Team Overwhelming Response to SmartCare Overwhelming Response to SmartCare Overwhelming Response to SmartCare Overwhelming Response to SmartCare Celebrating African American Women Firsts Celebrating African American Women Firsts Celebrating African American Women Firsts Celebrating African American Women Firsts Nutrition Department Hosts Food Drive Nutrition Department Hosts Food Drive Nutrition Department Hosts Food Drive Nutrition Department Hosts Food Drive	LITTLE ROCK – A researcher at the University of Arkansas for Medical Sciences (UAMS) has won a National Institutes of Health (NIH) grant for experiments that could lead to new therapies for controlling the spread of disease agents, including metastacizing cancer cells. The UAMS study seeks to understand the fundamentals of lymphatic function. A new way to clearly see the flow of lymphatic fluid at the cellular level could unlock the mystery of how metastatic cancer cells migrate through the body. Vladimir P. Zharov, Ph.D., is developing a high-resolution, high-contrast laser imaging system to observe cells as they move through the lymph system inside a living organism, something that so far has not been viewed. The study will focus the diagnostic laser equipment on the mesentery, the ultra-thin lining attached to the abdominal wall containing a single layer of blood and lymph microvessels. “It is surprising that so little is known of microlymphatic fundamentals, including mechanism of propulsion, valve function, and other things,” Zharov, director of the Phillips Classic Laser Laboratory in the Arkansas Cancer Research Center at UAMS, said. “To date, blood microcirculation has been studied in detail, while the lymphatic system has been paid much less attention.” The laser technique will allow visualization of even single cells in blood and lymphatic microvessels, including red blood cells, leukocytes, and platelets. It will also allow scientists to measure lymphatic flow, creating what is called the “velocity profile.” Zharov even hopes to be able to estimate the viscosity of the lymph fluid. Because several diseases, including lymphedema, lymphatic malformations, port-wine stains, and cancer, disrupt lymphatic function, Zharov’s optical laser system has a broad spectrum of possible biomedical applications. The grant of $417,277 for two years is from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at NIH. One of the long-term goals of the study is to test the laser system’s capability for studying how the microvascular system reacts to various therapies, such as drugs or laser treatment, including a study of micro injury to the vessels’ walls. Zharov, who came to UAMS from his native Moscow in 2000, also is investigating a laser-based treatment of lymphedema (limb swelling) after breast cancer surgery, a way to customize chemotherapy using laser technology, and a way to bind breast cancer cells with tiny gold particles in order to kill the cells with a laser pulse.
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