• Questions About Raises, Shuttle Fees Top Administrators Forum
  A UAMS Update article about Meet Your Administrator”
  

 
• Gruenwald Is New U.S. Citizen
  Michael Gruenwald becomes U.S. citizen
  

 
• Gruenwald Is New U.S. Citizen
  Michael Gruenwald becomes U.S. citizen
  

 
• Doughnut Sale to Help UAMS Psychiatry Youth Program
  A UAMS Update article about a bake sale
  

 
• Call-in Announcements, Forums Will Give Employees More Information
  A UAMS Update article about plans to improve communication between administration and employees of UAMS Medical Center
  

 
• IT Help Desk 400,000th Call Sweepstakes
  IT Help Desk 400,000th Call Sweepstates
  

 
• The UAMS Help Desk Today - Ten Years Later
  The UAMS Help Desk Today - Ten Years Later
  

 
• Free Tickets for UAMS Nights at Ray Winder Field
  A UAMS Update article about UAMS Night with the Travelers
  

 
• ARIA Training Sessions May 19 - June 27 at UAMS
  A UAMS Update article about May 19 - June 27 training sessions
  

 
• Human Research Forum Is May 21
  A UAMS Update article about human research Q & A
  

 
• Accolades, May 2003
  Accolades to UAMS faculty and staff
  

 
• GCRC Deadline Changed to July 1 for Grant Proposals
  A UAMS Update article about GCRC pilot grants
  

 
• History of the Help Desk
  
  

 
• Watch, Look & Listen: Preview of New UAMS Public Service Campaign
  
  

 
• Forum to Discuss Impact of HIPAA on Research
  Update article about HIPAA and research at UAMS
  

 
• Human Research Q and A Forum June 27
  A UAMS Update article about the human research forum
  

 
• Emailed Version of UAMS Notice of Privacy Practices
  UAMS Notice of Privacy Practices
  

 
• Free UAF Symposium Aug. 14-15 on Evolution of Human Diet
  A UAMS Update article about a diet symposium at UAF
  

 
• Tom Butler is Arkansas Administrator of the Year
  Tom Butler of UAMS Is Arkansas Administrator of the Year
  

 
• Join the Prostate Cancer Race Walk. Click Here for Registration Form.*
  Join the Prostate Cancer Race Walk. Click Here for Registration Form.
  

 
• Join the Prostate Cancer Race Walk. Click Here for Registration Form.*
  Join the Prostate Cancer Race Walk. Click Here for Registration Form.
  

 
• Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
  Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
  

 
• Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
  Defense Department Funds Possible Therapeutic Vaccine for Ovarian Cancer at UAMS
  

 
• Join UAMS/ACRC Team in Race for the Cure®!
  Join UAMS/ACRC Team in Race for the Cure!
  

 
• Join UAMS/ACRC Team in Race for the Cure®!
  Join UAMS/ACRC Team in Race for the Cure!
  

 
• UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
  UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
  

 
• UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
  UAMS Scientist Receives $272,000 Grant for Tailoring Cancer Treatments with Laser Test
  

 
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  Photo Album: Stephens Institute Was a Highlight of Medicine Alumni Reunion
  

 
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  Kids First in Fort Smith Celebrated Fourth in Style
  

 
• Class of 1948 Dedicates Endowment to Excellence in Education
  Class of 1948 Dedicates Endowment to Excellence in Education
  

 
• Pharmacy Professor Elected to American College of Clinical Pharmacy
  Pharmacy Professor Elected to American College of Clinical Pharmacy
  

 
• Pharmaceutical Scientists, Graduate Students Meet at UAMS
  Pharmaceutical Scientists, Graduate Students Meet at UAMS
  

 
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  Stephanie Gardner, Pharm.D., Ed.D., Is Interim Dean of College of Pharmacy
  

 
• New COPH Survey Research Expert Eager to Develop New Ways of Measuring Public Health
  New COPH Survey Research Expert Eager to Develop New Ways of Measuring Public Health
  

 
• Ready, Set, Go! UAMS, KATV Launch Get Healthy Arkansas™
  UAMS, KATV Launch Get Healthy Arkansas™
  

 
• Breast Augmentation
  Breast Augmentation
  

 
• Breast Augmentation
  Breast Augmentation
  

 
• Depression in Women
  Clinical depression, or major depressive disorder, is a physical illness of the brain. There is much confusion about this illness because the term "depression" is often confused with the feeling of sadness
  

 
• Healthy Foods for a Healthy Heart
  Many women may be in danger of heart disease without even realizing they are. Fortunately, women can control some of the factors that contribute to heart disease
  

 
• Nutrition for Women
  Women’s nutritional needs at each stage of life.
  

 
• Oral Health for Women
  
  

 
• Skin Care for Women
  
  

 
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  Stress Management and how to handle it.
  

 
• Related Sites
  Links to related sites dealing with Women's Health Care
  

 
• Preventive Health Care for Women
  
  

 
• Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09)
  Novel biomarker profile for the management of metastisis to bone of patients with breast cancer.
  

 
• Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09)
  Novel biomarker profile for the management of metastisis to bone of patients with breast cancer.
  

 
• Novel plasma biomarker and marker profiles for analysis of metastatic disease: A unique fragment of parathyroid hormone related protein predicts breast metastasis to bone (11-09)
  Novel biomarker profile for the management of metastisis to bone of patients with breast cancer.
  

 
• Gray’s Anomaly: A Source of Empowerment
  Feb. 8, 2012 | “I’ll trim it so it’s not so bulky,” James Y. Suen, M.D., said as he folded, then snipped a tiny edge of gauze off before he placed it on his patient’s right jaw. He has cared for 23-year-old Jasmine Gray ever since she was 11 when she traveled from Memphis, Tenn. to see him after first being misdiagnosed.
  

 
• Need Something Sweet for Your Valentine?
  Need Something Sweet for Your Valentine?
  

 
• Need Something Sweet for Your Valentine?
  Need Something Sweet for Your Valentine?
  

 
• Code Moo Now Open
  Code Moo Now Open
  

 
• Code Moo Now Open
  Code Moo Now Open
  

 
• Sign Up for the UAMS House of Delegates Relay for Life Team
  UAMS House of Delegates Relay for Life Team
  

 
• Sign Up for the UAMS House of Delegates Relay for Life Team
  UAMS House of Delegates Relay for Life Team
  

 
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  Overwhelming Response to SmartCare
  

 
• Overwhelming Response to SmartCare
  Overwhelming Response to SmartCare
  

 
• Celebrating African American Women Firsts
  Celebrating African American Women Firsts
  

 
• Celebrating African American Women Firsts
  Celebrating African American Women Firsts
  

 
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  Nutrition Department Hosts Food Drive
  

 
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• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. 11-11
  Treatment of cardiovascular diseases, heart attack and stroke remain leading causes of death in the world, affecting close to 15 million individuals per year. Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. 11-11
  Treatment of cardiovascular diseases, heart attack and stroke remain leading causes of death in the world, affecting close to 15 million individuals per year. Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. 11-11
  Treatment of cardiovascular diseases, heart attack and stroke remain leading causes of death in the world, affecting close to 15 million individuals per year. Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  The present invention is a method of in vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. The Photo Acoustic technique based on detection of laser−induced acoustic waves provides greater sensitivity and spatial resolution in deeper tissue compared to the other optical modalities. In vivo multicolor flow cytometry, negative and positive PA contrasts integrated with focused ultrasound has potential for dynamic study of various clots directly in the bloodstream of superficial microvessels associated with different diseases (e.g., cardiovascular disorder, cancer metastasis, or infection) and their treatment (e.g., stents, implants, drugs) which otherwise could not be detected with existing techniques.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 
• In vivo flow cytometry with negative photo acoustic contrast for noninvasive, continuous, real−time detection of circulating clots. (11-11)
  Among various risk factors, circulating clots (termed also thrombi) may cause unexpected death or stoke. At present no clinically relevant method has been developed for early detection of circulating clots despite their clinical significance as prognostic markers for preventing stroke and heart attacks.
  

 

Cessation of menstrual periods.

What is the cause of menopause?

• The woman runs out of eggs.
• Estrogen production drops dramatically.
• Menopause frequently is preceded by a few years of perimenopause.

What are the initial symptoms of perimenopause?

• Menstrual cycles are frequently shorter.
• Menstrual cycles are often irregular.
• Many women will begin having hot flashes.

What are the initial symptoms of menopause?

• Cessation of menstruation
• Hot flashes
• Irritability
• Mood disturbances
• Headache
• Insomnia
• Occasional depression

What symptoms occur a few years after the onset of menopause?

• Vaginal dryness
• Painful intercourse
• Vaginal discharge
• Leaking of urine with coughing, sneezing or lifting
• Wrinkled, thin skin
• Decreased peripheral sensitivity

What diseases could be associated with estrogen deficiency?

• Osteoporosis is proven to be associated with estrogen deficiency.
• The following diseases are probably caused by estrogen deficiency:
• Heart disease
• Colon cancer
• Alzheimer’s disease
• Possible
• Macular degeneration
• Cataracts

The answer to this question is complicated. Estrogen treatment decreases the risk of dying from breast cancer. However, estrogen treatment increases the risk of developing breast cancer.

There is a minimal increase in the risk of blood clots.

Estrogen treatment reduces the risk of dying from heart disease, colon cancer, and breast cancer.

Estrogen treatment increases independent living by reducing nursing home admissions due to fractured hips, heart attacks, and Alzheimer’s disease; and improves sexual function and bladder control.

What are possible side effects of estrogen?

• Breast tenderness
• Vaginal bleeding in women with a uterus.
• Bloating, especially with progestin treatment
• Minimal risk of blood clots

Current recommendations include a combination of estrogen, vitamin E, and ibuprofen.

What other drugs prevent osteoporosis?

• Bisphosphonates (i.e. Fosamax)
• SERMS (i.e. Evista)

What are the advantages of bisphosphonates?

• Very effective
• No hormonal side effects
• Increases effectiveness of estrogen or SERMS in combination

What are the problems with bisphosphonates?

• No non-osteoporosis benefits
• High rate of gastrointestinal irritation

What are the benefits of Evista?

Reduces invasive breast cancer (in comparison to a placebo drug) by 75 percent

• Reduces cholesterol
• No vaginal bleeding or breast tenderness

What are the risks of Evista?

• Minimal risk of blood clots
• No long-term users
• Unknown effect on heart, brain, colon, etc.
• Mild increase in hot flashes
• Leg cramps

Women with estrogen deficiency symptoms should receive estrogen treatment. Women with uterus also should take progestin.

Postmenopausal women with few or no symptoms of estrogen deficiency should discuss treatment options with their physicians. Potential non-bone benefits of treatments should be considered. Estrogen appears to have the most positive benefits. Evista reduces breast cancer. Fosamax has no added non-bone benefits.

Michael M. Miller, M.D., is associate professor of obstetrics and gynecology and director of the Division of Reproductive Endocrinology-Infertility at the University of Arkansas for Medical Sciences.

Related Site
UAMS Department of Obstetrics and Gynecology:
http://www.uams.edu/obgyn/obgyn.htm

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