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FEB.
28, 2002 | Scientists and health care professionals at
the University of Arkansas for Medical Sciences (UAMS)
have joined an international network of cutting-edge
researchers studying Huntington’s disease.
The UAMS team will participate in international
research concerning Huntington’s disease (HD), a
rare inherited progressive degenerative brain
disorder. The Huntington
Study Group (HSG) is a network of physicians,
scientists, social workers, and other experts in the
United States, Canada, Europe, and Australia who
collaborate on cutting-edge research about the
disease.
”The Huntington’s Disease Study Group is making
seminal contributions to medicine’s knowledge of
this disease through large, unbiased multi-center
clinical trials examining the symptomatic and
neuroprotective effects of experimental interventions
in Huntington’s disease,” Samer D. Tabbal, M..D.,
explained. ”Our joining the HSG would not have been
possible without the valuable contribution of each
member of the multi-disciplinary Huntington’s
disease clinic” at UAMS, he said. Dr. Tabbal is
director of the clinic and an assistant professor in
the Department
of Neurology in the UAMS College of Medicine.
The Arkansas chapter of the Huntington’s
Disease Society of America estimates that at
least 150 Arkansans have overt symptoms of HD,
indicating that all of their family members are at
risk of developing the disease. As the illness
progresses, patients may suffer from psychiatric
problems including depression, irritability, anxiety,
alcoholism, aberrant sexual behavior, and
schizophrenia; difficulty with comprehension; speech
problems; distinctive involuntary movements, and
clumsiness.
The disease typically develops in the patient’s 30s
or 40s but can begin as early as age 2 and as late as
age 70. The disease progresses gradually over
approximately 15 years before death.
Many primary care physicians have trouble diagnosing
or treating the disease because it is so rare; some
may misdiagnose a patient as alcoholic. UAMS Medical
Center launched its HD Clinic, the first in Arkansas,
in May 2001. To guarantee that they evaluate and treat
all symptoms of the disease, all team members in the
clinic participate in thorough evaluations of patients
during each clinic visit.
Joining the HSG demonstrates that the UAMS HD Clinic
provides “superior care to HD patients and their
families,” Dr. Tabbal observed.
Other researchers identified the gene that causes HD
in 1993, the same year that the HSG was organized. The
first major contribution of the HSG was the Unified
Huntington’s Disease Rating Scale, now in use
worldwide. The scale has enabled researchers to
compile an international database of symptoms in order
to study the natural progression of the illness. The
study group now has more than 269 active
investigators, coordinators, and scientists at about
60 sites. Ira Shoulston, M.D., of the University of
Rochester, a worldwide authority on movement disorders
and clinical study design, is chairman of the HSG
Executive Committee.
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Speech
and language patholigist Richard Zraick, Ph.D.,
examines a patient at the UAMS Medical Center
Huntington’s Disease Clinic. (JohnPaul Jones)

Samer
D. Tabbal, M.D., leads a staff discussion at the UAMS
Medical Center Huntington’s Disease Clinic. (JohnPaul
Jones)

Roger
D. Williams, Ph.D., director of neurpsychology services at
UAMS Medical Center, talks with a patient. (JohnPaul
Jones)

Winston
Brown, M.D., and nurse Deborah Fewell, LPN II,
confer at the Huntington’s Disease Clinic. (JohnPaul
Jones)

Social worker Alan Hulen
listens to a patient discuss Huntington’s disease. (JohnPaul
Jones)

For
more information or to make an appointment at
the UAMS Huntington’s Disease Clinic, call
501-603-1223. |
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Huntington’s
Disease Society of America-Arkansas Chapter
1-800-558-3370
P.O. Box 56441
Little Rock, AR
72215
www.hds.org |
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As
an HSG site, the UAMS HD Clinic will offer patients the
opportunity to participate in tests of new medications for the
disease. The National Institute of Medicine and the
Huntington’s Disease Society of America are sponsoring various
studies of medications which may prove to delay the onset of HD
symptoms, alleviate symptoms, or even cure the disease.
Previously, Arkansans with HD had to travel to Houston or St.
Louis to receive experimental drugs.
The UAMS HD Clinic team includes the following members:
Samer D. Tabbal, M.D.
C. Winston Brown, M.D.
Roger D. Williams, Ph.D.
Richard Zraick, Ph.D.
Deborah Fewell, LPN II
Becky Butler, L.C.S.W.
Nancy Harris, L.C.S.W.
Alana House Hulen, L.S.W.
Genetic Services
Samer D. Tabbal, M.D.,
is medical director of the UAMS HD Clinic and UAMS HSG site.
He is an assistant professor
of neurology in the Department of Neurology of the UAMS College
of Medicine and at the Central Arkansas Veterans Healthcare
System (VA) in Little Rock. He is also the movement disorder
specialist of the UAMS Medical Center's Center on Aging. He
completed his fellowship training in movement disorders in June
1999 at Columbia University, College of Physicians &
Surgeons in New York City, under the supervision of Stanley Fahn,
M.D., who is one of the most prominent worldwide authorities in
the field. This was after three years of neurology residency
training at UAMS. He graduated in 1993 from the American
University of Beirut, Beirut, Lebanon after completing a B.Sc.
in physics as premedical training.
Dr.
Tabbal is certified by the American Board of Neurology and
Psychiatry and is director of the Neurology Residency Program in
the College of Medicine. His academic interests include movement
disorders associated with dementia and aging, Parkinson’s
disease, Parkinson-Plus syndromes (like progressive supranuclear
palsy, corticobasal ganglionic degeneration, striato-nigral
degeneration, and Shy-Drager syndrome), Huntington’s disease,
cerebellar ataxias, tremors, gait/balance disorders, normal
pressure hydrocephalus, dystonia (like torticollis,
blepharospasm, facial/limb dystonia, writer’s cramp,
generalized dystonia), Botulinum toxin therapy, tic disorders,
myoclonus, tardive dyskinesias, and other drug-induced movement
disorders.
He has lived with HD patients at a week-long camp in order to
learn firsthand the problems of these patients and their
families.
Dr. Tabbal also directs a Parkinson’s
Study Group site at UAMS with Jana Patterson, R.N.
C. Winston Brown,
M.D., is an associate professor in the Department
of Psychiatry and Behavioral Sciences in the UAMS
College of Medicine. He maintains an adult practice in the Adult
Psychiatry Clinic and oversees the management and development of
psychiatric services for the adult behavioral health programs at
UAMS.
Dr. Brown earned his bachelor’s degree from the University of
Arkansas at Fayetteville and his medical degree from the UAMS
College of Medicine. He studied internal medicine at the Emory
University Affiliated Hospitals for one year before completing a
residency in adult psychiatry at Vanderbilt University. Before
joining the UAMS faculty, Dr Brown practiced privately in LR
from 1977 until 1993 and served as chief of the North Little
Rock VA Mental Health Clinic from 1993 until 1996.
Dr Brown is certified by the American Board of Neurology and
Psychiatry. At UAMS, he is active in investigating systems to
assess the effectiveness of care for psychiatric disorders in
routine practice settings and works with groups across the US in
implementing such systems.
Dr.
Brown provides optional diagnostic psychiatric evaluations for
HD patients and treats patients who experience psychiatric
symptoms, sometimes involving other mental health providers. He
coordinates the use of psychiatric medications and sees HD
patients outside regular clinic hours if necessary.
Roger D. Williams, Ph.D.,
is an assistant professor of geriatrics in the Donald W.
Reynolds Department
of Geriatrics in the UAMS College of Medicine. He is
director of Neuropsychology Services at UAMS. He earned his
Ph.D. in psychology from Indiana State University where he was
the Imogene E. Okes Fellow and was elected to Phi Delta Kappa
honor society in education.
Dr. Williams earned the master’s degree in psychology at the
University of Notre Dame and completed a clinical psychology
internship with specialization in neuropsychology at the Central
Arkansas Veterans Health Care System (VA) in Little Rock. After
completing his clinical training, Dr. Williams entered private
practice in Terre Haute, Indiana. He was also a consultant for
the VA Medical Center in Danville, Illinois, and an adjunct
faculty member at Indiana State University. Before joining the
Donald W. Reynolds Department of Geriatrics in the UAMS College
of Medicine, he completed a fellowship in clinical
geropsychology and neuropsychology at the VA in 1997.
Dr. Williams is certified by the Council for the National
Register of Health Service Providers in Psychology. He is a
member of the Clinical Psychology Internship Training Committee
at the Central Arkansas Veteran’s Health Care System. He is
the neuropsychologist for the Alzheimer’s
Disease Center at UAMS. His academic interests include
Alzheimer’s disease and related disorders, neuropsychological
assessment, multi-disciplinary approaches to assessment,
neuropsychological effects of pharmacological interventions, and
movement disorders.
Richard Zraick, Ph.D.,
CCC-SLP, is an assistant professor in the Department
of Audiology and Speech Pathology in the UAMS College of
Health Related Professions. He was awarded his Bachelor's degree
in 1984 (Psychology) and Master's degree in 1987
(Speech-Language Pathology) by the University of Arizona, and
his doctoral degree (Speech-Language Pathology) in 1998 by
Arizona State University. He joined the UAMS faculty in July
1997.
Dr.
Zraick holds the Certificate of Clinical Competence (CCC-SLP)
awarded by the American Speech-Language-Hearing Association, and
is completing board certification in adult neurological
communication disorders by the Academy of Neurological
Communication Disorders and Sciences. A practicing clinician
since 1987, Dr. Zraick routinely diagnoses and treats persons
who have lost some or all of their ability to communicate or
swallow due to acquired medical conditions such as stroke, head
injury, and neurological disease.
Dr.
Zraick is a published author, with research grants and research
articles, and book chapters in the areas of neurogenic
speech-language disorders, voice disorders and speech
perception. He has been an invited speaker about these topics at
state and national scientific conventions. In 1999, Dr. Zraick
was awarded a New Investigator Grant from the American
Speech-Language-Hearing Association. The Arkansas Speech and
Hearing Association honored Dr. Zraick with its annual
Researcher Award in 2000.
Deborah Fewell, LPN II, is a
nurse in the Department of Neurology at UAMS. She joined UAMS in
1995. She performs nerve conduction studies in the
Electrophysiology Laboratory and is research coordinator for
studies involving stroke, ALS, epilepsy and Huntington's
disease. Fewell is also the nurse coordinator of the Motor
Neuron Disease and Huntington's Disease Clinics. She coordinates
the Muscular Dystrophy Motor Neuron Disease Support Group and is
co-coordinator of the Huntington's Disease Interactive Video
Support Group.
As
the HD nurse, Fewell coordinates the entire clinic visit of each
patient from scheduling appointments to instructing patients
upon discharge. She develops and implements the plan of care to
meet nursing and psychological needs of patients and their
family. She also attends to patients needs between clinic
visits, including supportive counseling and psychological
emergencies.
”I have widespread clinic responsibilities,” Fewell
explains. “I help our team of physicians assess the patients
and their families during their HD Clinic visits. Working with
the other team members, I develop a health care plan to meet
nursing and psychosocial needs of the patient and family. I am
available during the week to answer questions, refill
medications, and provide supportive counseling. I can also be
reached in case of a HD crisis.”
Becky Butler, L.C.S.W., is a
social worker and has a special interest in genetic counseling
for patients who may be at risk of passing a genetic disorder on
to children. She helped organize the HD Clinic and
coordinates bimonthly HD Support Group meetings through
interactive video. She also is coordinator of
telegenetics for the Department
of Obstetrics and Gynecology in the UAMS College of
Medicine.
Nancy Harris, L.C.S.W., is a
psychotherapist. HD has a profound impact on the social and
emotional functioning of patients and their families. Harris is
available to patients and family members who request therapy
services as they adjust to the impact of HD. Sessions can focus
on adjusting to the functional changes in the patient and
family, grief work related to role and functional losses,
teaching and facilitating communication, problem-solving and
conflict resolution skills, stress management, self-care for
caregivers, and helping children understand and cope.
For patients who do not live in the immediate area, Ms. Harris
can assist with referrals to nearby mental health services.
Harris earned the bachelor’s degree from the University of
Memphis and the master of social work from the University of
Arkansas at Little Rock (UALR).
Alana
House Hulen,
B.S.W., is a social worker.
She provides resources, such as information about
financial assistant, to patients, caregivers, and families.
She conducts periodic functional assessments of patients.
Hulen earned a degree in social work from Lyon College and has
experience in medical social work and as director of social
services in a nursing home.
She is completing work on the master of social work
degree at UALR.
Genetic Services in the HD
Clinic include genetic counseling referrals to Mary Curtis,
M.D., a board-certified clinical geneticist, and counseling by
Erica Burner in the Clinical Genetics Division of Arkansas
Children’s Hospital (501-320-2966).
Links
on This Page
Huntington Study Group: http://huntington-study-group.org/
Huntington’s Disease Society of America: http://www.hdsa.org/
Department of Neurology: http://www.uams.edu/neurology/index.htm
Parkinson Study Group: http://www.parkinson-study-group.org/
Department of Psychiatry: http://www.psych.uams.edu/
Department of Geriatrics: http://centeronaging.uams.edu/
Alzheimer’s Disease Center: http://alzheimer.uams.edu/
Department of Audiology an Speech Pathology: http://www.ualr.edu/~audiology/
Department of Obstetrics and Gynecology: http://www.uams.edu/obgyn/obgyn.htm
© 2002
University of Arkansas for Medical Sciences (UAMS). A single
copy of these materials may be reprinted for noncommercial
personal use only. “UAMS,” “UAMS Medical Center,”
“UAMS Online,” “UAMS Today,” “uams.edu,” and
“Here’s to Your Health” are marks of UAMS.
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