Nuclear Medicine Research     PET-CT Scan Research     PET-CT Scan Equipment      Faculty     Nuclear Medicine Program Information

Residents will have many opportunities to participate in cutting-edge research during their training. At this time, we are doing clinical research investigating the use of FDG (fluorodeoxyglucose) PET-CT scanning in multiple myeloma and related plasma cell dyscrasias. We also have a pilot grant using PET-CT in patients with newly diagnosed breast cancer. We are evaluating dual-time point FDG PET in lung cancer to see if this can differentiate between cancer and previous infection, such as previous histoplasmosis, a very common fungal infection in Arkansas. We are also doing research in early detection of occult infection in the immune compromised patient and in the setting of orthopedic prostheses. Many papers and presentations, book chapters, etc., have come from the faculty as shown below.

Journal articles are available electronically at PubMed: http://www.ncbi.nlm.nih.gov/entrez

(1) Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy Jr JD.  The molecular classification of multiple myeloma. Blood; 2006 [prepublished online May 25, 2006].

(2) Epstein J, Walker R. Myeloma and bone disease: "the dangerous tango". Clin Adv Hematol Oncol. Apr 2006; 4(4):300-6.

(3) Jones-Jackson L, Walker R, Purnell G, McLaren SG, Skinner RA, Thomas JR, Suva LJ, Anaissie E, Miceli M, Nelson CL, Ferris EJ, Smeltzer M. Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model. Journal of Orthopedic Research Nov 2005; 23(6): 1484-9.

(4) Mahfouz T, Miceli MH, Saghafifar F, Stroud S, Jones-Jackson L, Walker R, Grazziutti ML, Purnell G, Fassas A, Tricot G, Barlogie B, Anaissie E. 18F-fluorodeoxyglucose positron emission tomography contributes to the diagnosis and management of infections in patients with multiple myeloma: a study of 165 infectious episodes. Journal of Clinical Oncology Nov 2005; 23(31):7857-63.

(5) Talamo G, Angtuaco E, Walker RC, Dong L, Miceli MH, Zangari M, Tricot G, Barlogie B, Anaissie E. Avascular necrosis of femoral and/or humeral heads in multiple myeloma: results of a prospective study of patients treated with dexamethasone-based regimens and high-dose chemotherapy. Journal of Clinical Oncology Aug 2005; 23(22):5217-23.

(6) Kelly T, Suva LJ, Huang Y, MacLeod V, Miao MV, Walker RC, Sanderson RD. Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Research Jul 2005; 65(13): 5778-84.

(7) Walker RC. Focus on myeloma and plasma cell disorders. IDrugs Mar 2005; 8(3): 189-92.

(8) Maxwell CA, Rasmussen E, Zhan F, Keats JJ, Adamia S, Strachan E, Crainie M, Walker R, Belch AR, Pilarski LM, Barlogie B, Shaughnessy J Jr, Reiman T.  RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma. Blood Aug 2004; 104(4): 1151-8.

(9) Miceli M, Atoui R, Walker R, Mahfouz T, Mirza N, Diaz J, Tricot G, Barlogie B, Anaissie E. Diagnosis of deep septic thrombophlebitis in cancer patients by fluorine-18 fluorodeoxyglucose positron emission tomography scanning: a preliminary report. Journal of Clinical Oncology May 2004; 22(10):1949-56.

(10) Miceli MH, Jones-Jackson LB, Walker RC, Talamo G, Barlogie B, Anaissie EJ. Diagnosis of infection of implantable central venous catheters by [18F] fluorodeoxyglucose positron emission tomography. Nuclear Medicine Communications , Aug 2004; 25(8):813-8.

(14) Walker RC, Purnell GL, Jones-Jackson LB, Thomas KL, Brito JA, Ferris EJ. Introduction to PET imaging with emphasis on biomedical research. Neurotoxicology Jun 2004; 25(4): 533-42. [Review]

(12) Miceli M, Atoui R, Thertulien R, Barlogie B, Anaissie E, Walker R, Jones-Jackson L. Deep septic thrombophlebitis: an unrecognized cause of relapsing bacteremia in patients with cancer. Journal Clinical Oncology; Apr 2004; 22(8):1529-31.

(13) Angtuaco EJ, Fassas AB , Walker R, Sethi R, Barlogie B. Multiple myeloma: clinical review and diagnostic imaging. Radiology Apr 2004; 231(1):11-23

(15) Barlogie B, Shaughnessy J, Tricot G, Jacobson J, Zangari M, Anaissie E, Walker R, Crowley J. Treatment of multiple myeloma. Blood Jan 2004; 103(1):20-32.

(16) Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B, Shaughnessy JD Jr. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. New England Journal of Medicine Dec 2003; 349(26):2483-94.
Comment in:
N Engl J Med. 2003 Dec 25;349(26):2479-80.
N Engl J Med. 2004 Apr 1;350(14):1464-6; author reply 1464-6.
N Engl J Med. 2004 Apr 1;350(14):1464-6; author reply 1464-6.
N Engl J Med. 2004 Apr 1;350(14):1464-6; author reply 1464-6.
N Engl J Med. 2004 Jul 8;351(2):197-8.

(17) Walker RC, Zigler SS. PET practice in nuclear pharmacy. J Am Pharm Assoc Sep-Oct 2003; 43(5 Suppl 1):S42-43

(18) Walker RC, Weiss DW, Purnell GL, Forte KF. Positron emission tomography scanning: a primer. J Ark Med Soc. Oct 2002; 99(4):119-21.

BOOK CHAPTERS:

Walker RC, Jones-Jackson LB, Rasmussen E, Miceli M, Angtuaco EJC, Van Rhee F, Tricot GJ, Epstein J, Anaissie EJ, Barlogie B. PET and PET/CT imaging in multiple myeloma, solitary plasmacytoma, MGUS and other plasma cell dyscrasias in Positron Emission Tomography: Clinical Practice, 2nd Edition . Valk, Delbeke, Bailey (Eds), Springer, 2006.

Barlogie B, Shaughnessy J, Epstein J, Sanderson R, Anaissie E, Walker R, Tricot G, Plasma Cell Myeloma in Williams Hematology, 7th Edition, Lichtman et al (Eds), McGraw-Hill, 2006.

Nuclear Medicine Research     PET-CT Scan Research     PET-CT Scan Equipment      Faculty     Nuclear Medicine Program Information

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