Z. Jimmy Zhou
Professor
Ph.D., University of Houston
Office: (501) 686-8128
Lab: (501) 686-8126
Email: ZhouJimmy@uams.edu

Our laboratory is interested in understanding synaptic, cellular, and network mechanisms of neuronal interactions in the mammalian retina as they relate to visual system development and visual signal integration.  Our current research focuses on (1) cellular and network mechanisms underlying spontaneous, rhythmic waves of excitation in the developing retina, (2) mechanisms of synaptic and dendritic integration in identified retinal neurons during visual processing, (3) retinal development and function in transgenic mice.  Experimental techniques currently used in the lab include: patch-clamp recordings from paired neurons in the intact mammalian retina and retinal slices, simultaneous patch clamp and calcium imaging in the retina, flash photolysis, biolistic gene transfection and fluorescence labeling, and computational modeling.

Pat and Willard Walker Eye Research Center
 

Dr. Zhou's Laboratory Homepage

Representative Publications

Lee S, Zhou ZJ (2006) The synaptic mechanism of direction selectivity in distal processes of starburst amacrine cells. Neuron 51:787-799 (also see Research Roundup in Journal of Cell Biology.  2 Oct, 2006, Doi:10.10.1083/jcb.1751rr3)

Zheng J^*, Lee S^*, Zhou ZJ (2006) A transient network of intrinsically bursting starburst cells underlies the generation of retinal waves. Nature Neuroscience 9(3):363-71. (* equal contribution)

Zheng JJ^*, Lee S^*, Zhou ZJ (2004) A developmental switch in the excitability and function of the starburst network in the Mammalian retina. Neuron 44:851-864 (* equal contribution) (also see “Highlights” in Science STKE2004:tw442; Nature Reviews Neuroscience 6:89, 2005, and Trends in Neurosciences 28: 395-396).

Syed MM, Lee S, He S, Zhou ZJ (2004) Spontaneous waves in the ventricular zone of developing mammalian retina. Journal of Neurophysiology 91:1999-2009 (also see Editorial Focus in Journal of Neurophysiology 91:1940, 2004).

Syed MM, Lee S, Zheng J, Zhou ZJ (2004) Stage-dependent dynamics and modulation of spontaneous waves in the developing rabbit retina. Journal of Physiology (Lond) 560:533-549.

Zhou ZJ, Zhao D (2000) Coordinated transitions in neurotransmitter systems for the initiation and propagation of spontaneous retinal waves. Journal of Neuroscience 20:6570-6577.

 

 Link to Dr. Zhou at Pub-Med

Questions about this page? Send us an email.
All contents © 2000-2006.

UAMS Online     Copyright Statement     Privacy Statement
 

updated 12/20/06