Jerry Ware

Professor
Ph.D., University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab:  (501) 526-7528
Email:  jware@uams.edu  

 Dr. Ware’s laboratory studies fundamental aspects of platelet biology to elucidate their role of in hemostasis, thrombosis and in the development of cardiovascular disease. Since platelets are anucleate fragments of cytoplasm, in vivo models are used based on the hypothesis that the unique cellular characteristics of megakaryocytes and platelets require the correct in vivo environment for meaningful assessment of biological properties. Currently, we are characterizing variants of the human glycoprotein Ib receptor expressed on the surface of circulating mouse platelets. Methodologies include the generation of transgenic and gene-targeted deletions in the mouse genome. These studies are defining the molecular mechanisms controlling normal platelet generation and the role of specific platelet receptors in disease.

Representative Publications

Hughan, S.C., Hughes, C.E., McCarty, O.J., Schweighoffer, E., Soultanova, I., Ware, J., Tybulewicz, V.L., Watson, S.P. 2007 Arterioscler Thromb Vasc Biol 27:422-429.

Cheli, Y., Jensen, D., Marchese, P., Habart, D., Wiltshire, T., Cooke, M., Fernandez, J.A., Ware, J., Ruggeri, Z.M. and Kunicki, T.J.  2007   The Modifier of Hemostasis (MH) locus on mouse chromosome 4 controls in vivo hemostasis of Gp6-/- mice.  Blood, In Press.

Suva, L.J., Hartman, E., Dilley, J.D., Russell, S., Akel, N.S., Skinner, R.A., Budde, U., Varughese, K.I., Kanaji, T. and Ware, J.  2007 Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathology, In Press.

Jain, S., Zuka, M., Liu, J., Russell, S., Dent, J.A., Guerrero, J.A., Forsyth, J., Maruszak, B., Gartner, T.K., Felding-Habermann, B. and Ware, J.   2007  Platelet glycoprotein Ibα supports experimental lung metastasis.  Proc Natl Acad Sci USA 104:9024-9028.

Liu, J., Ware, J., Jackson, C.W. and Gartner, T.K. 2007 FcR-chain dependent IIb3 elicited outside-in signaling. J. Thromb Haemost 5:426-428.

Liu, J., Ware, J., Jackson, C.W. and Gartner, T.K.  2007 FcR-chain signals in the absence of GP VI. J Thromb Haemost  5:201-203.

Bergmeir, W., Piffath, C.L., Goerge, T., Cifuni, S.M., Ruggeri, Z.M., Ware, J., Wagner DD. 2006  The role of platelet adhesion receptor GP Ib far exceeds that of its main ligand von Willberand factor in arterial thrombosis, Proc Natl Acad Sci USA 103:16900-16905.

Martinez, C., Corral, J., Dent, J.A., Sesma, L., Vicente, V., Ware, J. 2006 Platelet septin complexes form rings and associate with the microtubular network. J Thromb Haemost  4:1388-1395.

Kisucka, J., Butterfield, C.E., Duda, D.G., Eichenberger, S.C., Saffaripour, S., Ware, J., Ruggeri, Z.M., Jain R.K., Folkman, J., Wagner. D.D. 2006 Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci USA  103:855-860.

Konstantinides, S., Ware, J., Marchese, P., Almus-Jacobs, F., Loskutoff, D.J., Ruggeri, Z.M. 2006  Distinct antithrombotic consequences of platelet glycoprotein Ib and VI deficiency in a mouse model of arterial thrombosis. J Thromb Haemost  4:2014-2021.

Link to Dr. Ware at PubMed

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