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Jerry Ware
Professor
Ph.D., University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab: (501) 526-7528
Email: jware@uams.edu
Dr. Ware’s laboratory studies fundamental
aspects of platelet biology to elucidate their role of in hemostasis,
thrombosis and in the development of cardiovascular disease. Since platelets
are anucleate fragments of cytoplasm, in vivo models are used based
on the hypothesis that the unique cellular characteristics of megakaryocytes
and platelets require the correct in vivo environment for meaningful
assessment of biological properties. Currently, we are characterizing
variants of the human glycoprotein Ib receptor expressed on the surface of
circulating mouse platelets. Methodologies include the generation of
transgenic and gene-targeted deletions in the mouse genome. These studies
are defining the molecular mechanisms controlling normal platelet generation
and the role of specific platelet receptors in disease.
Representative
Publications
Fontana G, Ware J,
Cattaneo M. Haploinsufficiency of the platelet P2Y12 gene in a family with
congenital bleeding diathesis. Haematologica 2009;
94:581-84.
Cheli Y, Jensen D,
Marchese P, Habart D, Wiltshire T, Cooke M, Fernandez JA, Ware J, Ruggeri ZM,
Kunicki TJ. The Modifier of Hemostasis (MH) locus on chromosome 4 controls
in vivo hemostasis of Gp6-/- mice. Blood 2008;
111:1266-73.
Suva LJ, Hartman E,
Dilley JD, Russell S, Akel NS, Skinner RA, Hogue WR, Budde U, Varughese KI,
Kanaji T, Ware J. Platelet dysfunction and a high bone mass phenotype in a
murine model of platelet-type von Willebrand disease. American Journal of
Pathology 2008; 172:430-39.
Guerrero JA,
Shafirstein G, Russell S, Varughese KI, Kanaji T, Liu J, Gartner TK, Baumler
W, Jarvis GE, Ware J. In vivo relevance for platelet glycoprotein Iba
residue Tyr276 in thrombus formation. J Thromb Haemost
2008; 6:684-91.
Liu J, Joglekar M, Ware
J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK. Evaluation of the
physiological significance of botrocetin/ von Willebrand factor in vitro
signaling. J Thromb Haemost 2008;
6:1915-22.
Nishikii H, Eto K,
Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J,
Nakauchi H. Metalloproteinase regulation improves in vitro generation of
efficacious platelets from mouse embryonic stem cells. J Exp Med
2008; 205:1917-27.
Hughan SC, Hughes CE,
McCarty OJ, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VL, Watson SP.
GPVI Potentiation of Platelet Activation by Thrombin and Adhesion Molecules
Independent of Src Kinases and Syk. Arterioscler Thromb Vasc Biol
2007; 27:429.
Liu J, Ware J, Jackson
CW, Gartner TK. FcRg-chain
signals in the absence of GPVI. J Thromb Haemost 2007;
5:203.
Jain S, Zuka M, Liu J,
Russell S, Dent JA, Guerrero JA, Forsyth J, Maruszak B, Gartner TK,
Felding-Habermann B, Ware J. Platelet glycoprotein Iba
supports experimental lung metastasis. Proc Natl Acad Sci U S A 2007;
104:9024-28.
Link to Dr. Ware at PubMed
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