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Jerry Ware
Professor
Ph.D., University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab: (501) 526-7528
Email: jware@uams.edu
Dr. Ware’s laboratory studies fundamental
aspects of platelet biology to elucidate their role of in hemostasis,
thrombosis and in the development of cardiovascular disease. Since platelets
are anucleate fragments of cytoplasm, in vivo models are used based
on the hypothesis that the unique cellular characteristics of megakaryocytes
and platelets require the correct in vivo environment for meaningful
assessment of biological properties. Currently, we are characterizing
variants of the human glycoprotein Ib receptor expressed on the surface of
circulating mouse platelets. Methodologies include the generation of
transgenic and gene-targeted deletions in the mouse genome. These studies
are defining the molecular mechanisms controlling normal platelet generation
and the role of specific platelet receptors in disease.
Representative
Publications
Hughan, S.C., Hughes, C.E.,
McCarty, O.J., Schweighoffer, E., Soultanova, I., Ware, J.,
Tybulewicz, V.L., Watson, S.P. 2007 Arterioscler Thromb Vasc Biol
27:422-429.
Cheli, Y., Jensen, D.,
Marchese, P., Habart, D., Wiltshire, T., Cooke, M., Fernandez, J.A.,
Ware, J., Ruggeri, Z.M. and Kunicki, T.J. 2007 The Modifier of
Hemostasis (MH) locus on mouse chromosome 4 controls in vivo
hemostasis of Gp6-/- mice. Blood, In Press.
Suva, L.J., Hartman, E.,
Dilley, J.D., Russell, S., Akel, N.S., Skinner, R.A., Budde, U., Varughese,
K.I., Kanaji, T. and Ware, J. 2007 Platelet dysfunction and a high
bone mass phenotype in a murine model of platelet-type von Willebrand
disease. Am J Pathology, In Press.
Jain, S., Zuka,
M., Liu, J., Russell, S., Dent, J.A., Guerrero, J.A., Forsyth, J., Maruszak,
B., Gartner, T.K., Felding-Habermann, B. and Ware, J.
2007 Platelet
glycoprotein Ibα supports experimental lung metastasis. Proc Natl Acad
Sci USA 104:9024-9028.
Liu, J., Ware, J.,
Jackson, C.W. and Gartner, T.K. 2007 FcR-chain dependent IIb3 elicited
outside-in signaling. J. Thromb Haemost 5:426-428.
Liu, J., Ware, J.,
Jackson, C.W. and Gartner, T.K. 2007 FcR-chain signals in the absence of
GP VI. J Thromb Haemost 5:201-203.
Bergmeir, W., Piffath, C.L.,
Goerge, T., Cifuni, S.M., Ruggeri, Z.M., Ware, J., Wagner DD. 2006
The role of platelet adhesion receptor GP Ib far exceeds that of its main
ligand von Willberand factor in arterial thrombosis, Proc Natl Acad Sci
USA 103:16900-16905.
Martinez, C., Corral, J.,
Dent, J.A., Sesma, L., Vicente, V., Ware, J. 2006 Platelet septin
complexes form rings and associate with the microtubular network. J
Thromb Haemost 4:1388-1395.
Kisucka, J., Butterfield,
C.E., Duda, D.G., Eichenberger, S.C., Saffaripour, S., Ware, J.,
Ruggeri, Z.M., Jain R.K., Folkman, J., Wagner. D.D. 2006 Platelets and
platelet adhesion support angiogenesis while preventing excessive
hemorrhage. Proc Natl Acad Sci USA 103:855-860.
Konstantinides, S., Ware, J., Marchese, P., Almus-Jacobs, F.,
Loskutoff, D.J., Ruggeri, Z.M. 2006 Distinct antithrombotic consequences of
platelet glycoprotein Ib and VI deficiency in a mouse model of arterial
thrombosis. J Thromb Haemost 4:2014-2021.
Link to Dr. Ware at PubMed
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