Jerry Ware

Professor
Ph.D., University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab:  (501) 526-7528
Email:  jware@uams.edu  

 Dr. Ware’s laboratory studies fundamental aspects of platelet biology to elucidate their role of in hemostasis, thrombosis and in the development of cardiovascular disease. Since platelets are anucleate fragments of cytoplasm, in vivo models are used based on the hypothesis that the unique cellular characteristics of megakaryocytes and platelets require the correct in vivo environment for meaningful assessment of biological properties. Currently, we are characterizing variants of the human glycoprotein Ib receptor expressed on the surface of circulating mouse platelets. Methodologies include the generation of transgenic and gene-targeted deletions in the mouse genome. These studies are defining the molecular mechanisms controlling normal platelet generation and the role of specific platelet receptors in disease.

Representative Publications

Fontana G, Ware J, Cattaneo M. Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis. Haematologica 2009; 94:581-84.

Cheli Y, Jensen D, Marchese P, Habart D, Wiltshire T, Cooke M, Fernandez JA, Ware J, Ruggeri ZM, Kunicki TJ. The Modifier of Hemostasis (MH) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Blood 2008; 111:1266-73.

Suva LJ, Hartman E, Dilley JD, Russell S, Akel NS, Skinner RA, Hogue WR, Budde U, Varughese KI, Kanaji T, Ware J. Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. American Journal of Pathology 2008; 172:430-39.

Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T, Liu J, Gartner TK, Baumler W, Jarvis GE, Ware J. In vivo relevance for platelet glycoprotein Iba residue Tyr²⁷⁶ in thrombus formation. J Thromb Haemost 2008; 6:684-91.

Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK. Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling. J Thromb Haemost 2008; 6:1915-22.

Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H. Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med 2008; 205:1917-27.

 Hughan SC, Hughes CE, McCarty OJ, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VL, Watson SP. GPVI Potentiation of Platelet Activation by Thrombin and Adhesion Molecules Independent of Src Kinases and Syk. Arterioscler Thromb Vasc Biol 2007; 27:429.

Liu J, Ware J, Jackson CW, Gartner TK. FcRg-chain signals in the absence of GPVI. J Thromb Haemost 2007; 5:203.

Jain S, Zuka M, Liu J, Russell S, Dent JA, Guerrero JA, Forsyth J, Maruszak B, Gartner TK, Felding-Habermann B, Ware J. Platelet glycoprotein Iba supports experimental lung metastasis. Proc Natl Acad Sci U S A 2007; 104:9024-28.

Link to Dr. Ware at PubMed

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