Rosalia C. M. Simmen, Ph.D.
Professor
Ph.D., University of Hawaii

Research in my laboratory is focused on the regulators of gene expression in the mammary gland and uterus that are essential for these tissues’ proper function and development. We seek to understand how steroid hormones and extra-cellular factors including growth factors and dietary components regulate the normal (and abnormal as in tumorigenesis) development of these tissues and to characterize the key gene products and signaling molecules that mediate these events. We use a variety of in vivo and in vitro models in our studies. We also use diverse cellular and molecular techniques including gene arrays for gene discovery, cell lines for analyzing signaling pathways, and rats and mouse mutants for studying in vivo gene regulation.  The aim of all these studies is to provide important insights into regulatory mechanisms that control tissue growth and development in the whole animal.

Dr. Simmen's Laboratory Homepage

Arkansas Children's Nutrition Center

 Representative Publications

Su, Y., Simmen, F.A., Xiao, R. and Simmen, R.C.M.  2007.  Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors.  Physiol Genomics 30:8-16

Velarde, M.C., Zeng, Z., McQuown, J.R., Simmen, F.A. and Simmen, R.C.M.  2007.  Krüppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor α signaling in Ishikawa endometrial adenocarcinoma cells.  Mol Endocrinol 21: 2988-3001.

Su, Y., Eason, R.R., Geng,Y., Till, S.R., Badger, T.M. and Simmen, R.C.M.  2007. In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis. Carcinogenesis 28: 1046-1051.

Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, and Simmen RCM. (2005). The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.  Carcinogenesis doi:10.1093/Carcin/bgi131 [Epub ahead of print].  

Velarde MC, Geng Y, Eason RR, Simmen FA, and Simmen RCM. (2005). Null mutation of Krüppel-like factor 9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice. Biol.  Reprod. doi:10.1095/bioreprod.105.041855 [Epub ahead of print].

Simmen RC, Eason RR, McQuown JR, Linz AL, Kang TJ, Chatman L Jr., Till SR, Fujii-Kuriyama Y, Simmen FA, Oh SP.  (2004) Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Krüppel-like factor 9/basic transcription element binding protein-1 (BTEB1) gene. J. Biol. Chem. 279(28): 29286-29294.

 

Link to Dr. Simmen at Pub-Med

Link to Dr. Mercado-Simmen at Pub-Med

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