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Lawrence E. Cornett
Professor
Ph.D., University of California, Davis
Office: (501) 686-5441
Lab: (501) 686-7120
Email: CornettLawrenceE@uams.edu
Dr.
Cornett's research interests are focused on regulation of adrenergic
receptor gene expression in the rat lung and the homeostatic roles of
the neurohypophysial hormone vasotocin in the domestic chicken.
Adrenergic receptors mediate the effects of epinephrine and
norepinephrine. My laboratory has developed adeno-associated viral
vectors that express a functional β2-adrenergic receptor.
These vectors are being delivered to rat lung in order to increase β2-adrenergic
receptor function in airway epithelial cells. The long term goal is to
increase sensitivity of the airways to the relaxing effects of β2-adrenergic
agonists. Regarding the actions of vasotocin, immunohistochemical
techniques, radioimmunoassays and in situ hybridization histochemistry
are being used to investigate regulation of vasotocin gene expression in
the chicken hypothalamus under conditions of osmotic stress and during
oviposition. We have cloned and pharmacologically characterized
receptors that bind vasotocin and transduce its physiological effects in
the shell gland and anterior pituitary gland.
In
addition, Dr. Cornett is the Director of the Arkansas INBRE Program.
The goal of the Arkansas INBRE is to expand and strengthen the
biomedical research infrastructure of academic institutions in the state
by developing a multidisciplinary research network united by the
scientific theme of Cellular Signaling, Growth, and Differentiation.
Dr. Cornett's Laboratory
Homepage
INBRE Web Site
Representative Publications
Mikhailova, M.V., P. Mayeux, A. Jurkevich, W.J. Kuenzel, A. Periasamy,
Y. Chen, and L.E. Cornett (2007) Hetero-oligomerization between
vasotocin and corticotrophin-releasing hormone (CRH) receptors augments
CRH-stimulated cyclic AMP production. Molec. Endocrinol.
21:2178-2188.
Srivastava, R, L.E. Cornett, and C.M. Chaturvedi (2007) Effect of
photoperiod and estrogen on expression of arginine vasotocin and its
oxytocic-like receptor in the shell gland of the Japanese Quail. Comp.
Biochem. Physiol. 148:451-457.
Schnackenberg, B.J., S.M. Jones, C. Pate, B. Shank, L. Sessions, L.M.
Pittman, L.E. Cornett, and R.C. Kurten (2006) Isoproterenol, a
b-agonist,
attenuates EGF-stimulated wound closure in human airway epithelial
cells. Amer. J. Physiol. 290:L485-L491
Baeyens, D.A. and L.E. Cornett (2006) The cloned avian neurohypophysial
hormone receptors. Comp. Biochem. Physiol. 143:12-19.
Jurkevich,
A., L.R. Berghman, L.E. Cornett, and W.J. Kuenzel. (2005)
Characterization and immunohistochemical visualization of the vasotocin
VT2 receptor in the pituitary gland of the chicken, Gallus gallus. Gen.
Comp. Endocrinol 143:82-91.
Link
to Dr. Cornett at PubMed
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