Three areas of research are currently active in my
lab: 1) the effects of dietary factors on early development; 2) dietary
prevention of chronic diseases (such as cancer, cardiovascular disease,
and osteoporosis); and 3) diet and alcohol interactive effects on
endocrine regulated metabolic systems. Our group studies specific dietary
factors (such as isoflavones, carbohydrates, or specific digestive
peptides) on expression of various metabolic enzymes and the health
consequences of those effects. We have been interested in the
diet-dependent regulation of alcohol metabolizing enzymes (CYP2E1 and ADH),
and the nutritional status-dependent adverse effects of alcohol intake. We
have also been interested to determine in specific factors that might
prevent incidence of mammary, colon, prostate and skin cancers. Lastly, we
are studying epigenetic events related to early effects on specific events
that occur later in life.
Arkansas
Children' s Nutrition Center
Recent Publications
Ronis MJ,
Korourian S, Blackburn ML, Badeaux J, Badger TM; The role of
ethanol metabolism in development of alcoholic steatohepatitis in the rat.
Alcohol 2010 Mar; 44 (2): 157 ‑ 169.
Andres A,
Mitchell AD, Badger TM; QMR: validation of an infant and children
body composition instrument using piglets against chemical analysis.
Int
J Obes 2010 Apr; 34 (4): 775 ‑ 780.
Chen J‑R,
Lazarenko OP, Blackburn ML, Badger TM, Ronis MJ; A role for
ethanol‑induced oxidative stress in controlling lineage commitment of
mesenchymal stromal cells through inhibition of Wnt/beta catenin
signaling.
J Bone Min Res 2010 May; 25 (5): 1117‑1127.
Klein
MA, Nahin RL, Messina MJ, Rader JI, Thompson LU, Badger TM, Dwyer
JT, Kim YS, Pontzer CH, Starke‑Reed PE, Weaver CM; Guidance from an NIH
workshop on designing, implementing, and reporting clinical studies of soy
interventions.
J Nutr 2010
Jun 140 (6): 1192S ‑ 1204S.
Shankar
K, Kang P, Harrell A, Zhong Y, Marecki JC, Ronis MJ, Badger TM;
Maternal overweight programs insulin and adiponectin signaling in the
offspring.
Endocrinology 2010 Jun; 151 (6): 2577 ‑ 2589.
Link
to Dr. Badger at PubMed
Thomas M. Badger