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REGULATION OF PROKARYOTIC & EUKARYOTIC

Fall 2007 - GENE EXPRESSION (5143)

Course Director: Patricia Wight

Rayford Auditorium Room 106-2

Biomedical Research Center II

9:00 am – 11:00 am

 Recommended Text: Genes VIII (2004) Benjamin Lewin

Class Updates

Date Information

8/21

Welcome to Gene Expression

8/21

Dr. Smeltzer says  in the interest of time, you can delete slides 48-77 inclusive; we will start on Thursday with slide 78 (whole genome sequencing)

9/4

Dr. Raney has added supplemental slides to GE05

10/1

Dr. Raney has posted review questions on ERES in "Review" folder

10/7

Dr. Raney has posted additional review questions on ERES in "Review" folder

10/16

Dr. Crew will lecture on 10/23 (GE16) Dr. Zhang will lecture on 10/18 (GE17)

11/6

Dr. MacNicol says that the  Pyronnet etal, 2000 Cell paper is REQUIRED reading for Thursday.  You will discuss the paper after the lecture.  Vagner PDF is a review and is suggested reading.

11/8

Dr. MacNicol says that the Charlesworth etal, 2006 EMBO paper is REQUIRED reading for Tuesday.  You will discuss the paper after the lecture.  The PDF by Richter and Sonenberg 2005 is a suggested minireview.

11/13

 Dr. MacNicol says that the paper by Kiriakidou etal 2007 is REQUIRED reading.  You will discuss the paper after the lecture. The Small RNAs review is suggested reading.

 

Lecture Slides and Readings are located on ERES

Prerequisites:                It is recommended that the student has had an undergraduate course in biochemistry or molecular biology.

Objectives:                   The goal of this course is for students to acquire a working knowledge of the various methods by which gene expression can be controlled.  A side-by-side comparison of these mechanisms for both prokaryotes and eukaryotes will be explored.  It is anticipated that at the end of this course, students will become proficient at reading the primary literature in gene regulation.

 Course Structure:          The course is 3 credit hours which meets twice a week for 2 hours per session.  The course will be conducted by didactic lectures, as well as, class discussion of current reviews and primary papers.  The students will be assigned a grade solely based on exams.  Grades will be scaled with the class average @ B.

 Reading Material:          Readings will mainly consist of recent reviews and primary articles as assigned by the individual Instructors.  Genes IX, by Benjamin Lewin is recommended as a text for general background.  A copy of the text has been placed on reserve in the library.

 Course Evaluation:        The course will be evaluated by the students as per standard UAMS procedures.  Each Instructor will be also be evaluated by the students.

DATE

Lec

#

LECTURE

INSTRUCTOR

Tue,   08/21/07

GE01

Prokaryotic Genome Organization

Mark Smeltzer

Thur, 08/23/07

GE02

Operons

Mark Smeltzer

Tue,   08/28/07

GE03

Prokaryotic transcription

Chia Lee

Thur, 08/30/07

GE04

Regulation of prokaryotic transcription

Chia Lee

Tue,   09/04/07

GE05

Prokaryotic replication, repair and recombination

Kevin Raney

Thur, 09/06/07

 

EXAM 1 (8:00 – 11:30 AM)

Includes lectures from Smeltzer, Raney & Lee

 

Tue,   09/11/07

GE06

Eukaryotic Genome Organization

Helen Benes

Thur, 09/13/07

GE07

Eukaryotic replication and repair

Kevin Raney

Tue,   09/18/07

GE08

Eukaryotic replication and repair

Kevin Raney

Thur, 09/20/07

GE09

Eukaryotic Transcription

Patricia Wight

Tue,   09/25/07

GE10

Eukaryotic Transcription

Patricia Wight

Thur, 09/27/07

GE11

Eukaryotic Transcription

Patricia Wight

Tue,   10/02/07

GE12

Eukaryotic Transcription

Patricia Wight

Thur, 10/04/07

GE13

Eukaryotic Gene Regulation

Helen Benes

Tue,   10/09/07

 

EXAM 2 (8:00 – 11:30 AM)

Includes lectures from Benes, Raney & Wight

 

Thur, 10/11/07

GE14

Meiosis and Mitosis

Wayne Wahls

Tue,   10/16/07

GE15

Meiosis and Mitosis

Wayne Wahls

Thur, 10/18/07

GE16

Somatic Recombination

Mark Crew

Tue,   10/23/07

GE17

Posttranscriptional processing

Xuming Zhang

Thur, 10/25/07

GE18

RNA splicing

Xuming Zhang

Tue,   10/30/07

GE19

RNA splicing

Xuming Zhang

Thur, 11/01/07

GE20

Reverse transcription

Xuming Zhang

Tue,   11/06/07

 

EXAM 3 (8:00 – 11:30 AM)

Includes lectures from Wahls, Crew & Zhang

 

Thur, 11/08/07

GE21

Prokaryotic & Regulation of prokaryotic translation

Angus MacNicol

Tue,   11/13/07

GE22

Eukaryotic translation

Angus MacNicol

Thur, 11/15/07

GE23

Regulation of eukaryotic translation

Angus MacNicol

Tue,   11/20/07

 

No class

 

Thur, 11/22/07

 

THANKSGIVING BREAK

 

Tue,   11/27/07

GE24

Eukaryotic Differentiation & Development

Mari Davidson

Thur, 11/29/07

GE25

Eukaryotic Differentiation & Development

Mari Davidson

Tue,   12/04/07

 

EXAM 4 (8:00 – 11:30 AM)

Includes lectures from MacNicol & Davidson

 

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