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REGULATION OF PROKARYOTIC &
EUKARYOTIC
Fall 2008
- GENE EXPRESSION (5143)
Course Director: Patricia Wight
Rayford Auditorium Room 106-2
Biomedical Research Center II
9:00 am – 11:00
am
Recommended
Text:
Genes VIII (2004) Benjamin Lewin
Class
Updates
| Date |
Information |
|
8/19 |
Welcome to Gene
Expression |
|
11/03 |
Dr. Macnicol
reminds the students
that they should read the Pyronnet 2000 Cell paper BEFORE class. |
|
11/04 |
Dr. Macnicol states
that Students are encouraged to read Lodish etal, Molecular Cell
Biology 6th Ed, Chapter 6 pp 127-138 for background review.
(for lecture GE21) |
|
11/19 |
Dr. Macnicol has
posted discussion slides for lecture GE21,22,23 |
Lecture
Slides and Readings are located
on
ERES
Prerequisites:
It is recommended that the student has had an undergraduate course in
biochemistry or molecular biology.
Objectives:
The goal of this course is for students to acquire a working knowledge of the
various methods by which gene expression can be controlled. A
side-by-side comparison of these mechanisms for both prokaryotes and
eukaryotes will be explored. It is anticipated that at the end of this
course, students will become proficient at reading the primary literature in
gene regulation.
Course
Structure: The course is
3 credit hours which meets twice a week for 2 hours per session. The
course will be conducted by didactic lectures, as well as, class discussion of
current reviews and primary papers. The students will be assigned a
grade solely based on exams. Grades will be scaled with the class
average @ B.
Reading
Material: Readings will
mainly consist of recent reviews and primary articles as assigned by the
individual Instructors. Genes IX, by Benjamin Lewin is recommended as a
text for general background. A copy of the text has been placed on
reserve in the library.
Course
Evaluation: The course will be
evaluated by the students as per standard UAMS procedures. Each
Instructor will also be evaluated by the students.
DATE
|
Lec
# |
LECTURE |
INSTRUCTOR
|
|
Tue,
08/19/08 |
GE01 |
Prokaryotic Genome
Organization |
Mark Smeltzer |
|
Thur, 08/21/08 |
GE02 |
Operons |
Mark Smeltzer |
|
Tue,
08/26/08 |
GE03 |
Prokaryotic
transcription |
Chia Lee |
|
Thur, 08/28/08 |
GE04 |
Regulation of
prokaryotic transcription |
Chia Lee |
|
Tue,
09/02/08 |
GE05 |
Prokaryotic replication,
repair and recombination |
Kevin Raney |
|
Thur, 09/04/08 |
|
EXAM 1 (8:00 – 11:30 AM)
Includes lectures from
Smeltzer, Raney & Lee |
|
|
Tue,
09/09/08 |
GE06 |
Eukaryotic Genome
Organization |
Helen Benes |
|
Thur, 09/11/08 |
GE07 |
Eukaryotic replication
and repair |
Kevin Raney |
|
Tue,
09/16/08 |
GE08 |
Eukaryotic replication
and repair |
Kevin Raney |
|
Thur, 09/18/08 |
GE09 |
Eukaryotic Transcription |
Patricia Wight |
|
Tue,
09/23/08 |
GE10 |
Eukaryotic Transcription |
Patricia Wight |
|
Thur, 09/25/08 |
GE11 |
Eukaryotic Transcription |
Patricia Wight |
|
Tue,
09/30/08 |
GE12 |
Eukaryotic Transcription |
Patricia Wight |
|
Thur, 10/02/08 |
GE13 |
Eukaryotic Gene
Regulation |
Helen Benes |
|
Tue,
10/07/08 |
|
EXAM 2 (8:00 – 11:30 AM)
Includes lectures from
Benes, Raney & Wight |
|
|
Thur, 10/09/08 |
GE14 |
Meiosis and Mitosis |
Wayne Wahls |
|
Tue,
10/14/08 |
GE15 |
Meiosis and Mitosis |
Wayne Wahls |
|
Thur, 10/16/08 |
GE16 |
Genetic Recombination |
Wayne Wahls |
|
Tue,
10/21/08 |
GE17
|
Posttranscriptional processing
|
Xuming Zhang |
|
Thur, 10/23/08 |
GE18
|
RNA
splicing
|
Xuming Zhang |
|
Tue,
10/28/08 |
GE19
|
RNA
splicing
|
Xuming Zhang |
|
Thur, 10/30/08 |
GE20
|
Reverse
transcription
|
Xuming Zhang |
|
Tue,
11/04/08 |
|
EXAM 3 (8:00 – 11:30 AM)
Includes lectures from Wahls,
Crew & Zhang
|
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|
Thur, 11/06/08 |
GE21
|
Prokaryotic & Regulation of
prokaryotic translation
|
Angus MacNicol |
|
Tue,
11/11/08 |
|
No
class
|
|
|
Tue,
11/13/08 |
GE22
|
Eukaryotic translation
|
Angus MacNicol |
|
Thur, 11/18/08 |
GE23
|
Regulation of eukaryotic
translation
|
Angus MacNicol |
|
Tue,
11/20/08 |
GE24
|
Eukaryotic Differentiation & Development
|
Mari Davidson |
|
Thur, 11/25/08 |
GE25
|
Eukaryotic Differentiation & Development
|
Mari Davidson |
|
Thur, 11/27/08 |
|
THANKSGIVING BREAK
|
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|
Tue,
12/02/08 |
|
EXAM 4 (8:00 – 11:30 AM)
Includes lectures from
MacNicol & Davidson
|
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