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REGULATION OF PROKARYOTIC &
EUKARYOTIC
Fall 2007
- GENE EXPRESSION (5143)
Course Director: Patricia Wight
Rayford Auditorium Room 106-2
Biomedical Research Center II
9:00 am – 11:00
am
Recommended
Text:
Genes VIII (2004) Benjamin Lewin
Class
Updates
| Date |
Information |
|
8/21 |
Welcome to Gene
Expression |
|
8/21 |
Dr. Smeltzer says in the interest of time,
you can delete slides 48-77 inclusive; we will
start on Thursday with slide 78 (whole genome sequencing) |
|
9/4 |
Dr. Raney has added
supplemental slides to GE05 |
|
10/1 |
Dr. Raney has posted
review questions on ERES in "Review" folder |
|
10/7 |
Dr. Raney has posted
additional review questions on ERES in "Review" folder |
|
10/16 |
Dr. Crew will lecture
on 10/23 (GE16) Dr. Zhang will lecture on 10/18 (GE17) |
|
11/6 |
Dr. MacNicol says
that the Pyronnet etal, 2000 Cell paper is REQUIRED reading for
Thursday. You will
discuss the paper after the lecture. Vagner PDF is a review and is
suggested reading. |
|
11/8 |
Dr. MacNicol says
that the Charlesworth etal, 2006 EMBO paper is REQUIRED reading for Tuesday.
You will discuss the paper after the lecture.
The PDF by Richter and Sonenberg 2005 is a suggested minireview. |
|
11/13 |
Dr. MacNicol says
that the paper by Kiriakidou etal 2007 is REQUIRED reading. You
will discuss the paper after the lecture. The
Small RNAs review is suggested reading. |
Lecture
Slides and Readings are located
on
ERES
Prerequisites:
It is recommended that the student has had an undergraduate course in
biochemistry or molecular biology.
Objectives:
The goal of this course is for students to acquire a working knowledge of the
various methods by which gene expression can be controlled. A
side-by-side comparison of these mechanisms for both prokaryotes and
eukaryotes will be explored. It is anticipated that at the end of this
course, students will become proficient at reading the primary literature in
gene regulation.
Course
Structure: The course is
3 credit hours which meets twice a week for 2 hours per session. The
course will be conducted by didactic lectures, as well as, class discussion of
current reviews and primary papers. The students will be assigned a
grade solely based on exams. Grades will be scaled with the class
average @ B.
Reading
Material: Readings will
mainly consist of recent reviews and primary articles as assigned by the
individual Instructors. Genes IX, by Benjamin Lewin is recommended as a
text for general background. A copy of the text has been placed on
reserve in the library.
Course
Evaluation: The course will be
evaluated by the students as per standard UAMS procedures. Each
Instructor will be also be evaluated by the students.
DATE
|
Lec
# |
LECTURE |
INSTRUCTOR
|
|
Tue,
08/21/07 |
GE01 |
Prokaryotic Genome
Organization |
Mark Smeltzer |
|
Thur, 08/23/07 |
GE02 |
Operons |
Mark Smeltzer |
|
Tue,
08/28/07 |
GE03 |
Prokaryotic
transcription |
Chia Lee |
|
Thur, 08/30/07 |
GE04 |
Regulation of
prokaryotic transcription |
Chia Lee |
|
Tue,
09/04/07 |
GE05 |
Prokaryotic replication,
repair and recombination |
Kevin Raney |
|
Thur, 09/06/07 |
|
EXAM 1 (8:00 – 11:30 AM)
Includes lectures from
Smeltzer, Raney & Lee |
|
|
Tue,
09/11/07 |
GE06 |
Eukaryotic Genome
Organization |
Helen Benes |
|
Thur, 09/13/07 |
GE07 |
Eukaryotic replication
and repair |
Kevin Raney |
|
Tue,
09/18/07 |
GE08 |
Eukaryotic replication
and repair |
Kevin Raney |
|
Thur, 09/20/07 |
GE09 |
Eukaryotic Transcription |
Patricia Wight |
|
Tue,
09/25/07 |
GE10 |
Eukaryotic Transcription |
Patricia Wight |
|
Thur, 09/27/07 |
GE11 |
Eukaryotic Transcription |
Patricia Wight |
|
Tue,
10/02/07 |
GE12 |
Eukaryotic Transcription |
Patricia Wight |
|
Thur, 10/04/07 |
GE13 |
Eukaryotic Gene
Regulation |
Helen Benes |
|
Tue,
10/09/07 |
|
EXAM 2 (8:00 – 11:30 AM)
Includes lectures from
Benes, Raney & Wight |
|
|
Thur, 10/11/07 |
GE14 |
Meiosis and Mitosis |
Wayne Wahls |
|
Tue,
10/16/07 |
GE15 |
Meiosis and Mitosis |
Wayne Wahls |
|
Thur, 10/18/07 |
GE16 |
Somatic Recombination |
Mark Crew |
|
Tue,
10/23/07 |
GE17
|
Posttranscriptional processing
|
Xuming Zhang |
|
Thur, 10/25/07 |
GE18
|
RNA
splicing
|
Xuming Zhang |
|
Tue,
10/30/07 |
GE19
|
RNA
splicing
|
Xuming Zhang |
|
Thur, 11/01/07 |
GE20
|
Reverse
transcription
|
Xuming Zhang |
|
Tue,
11/06/07 |
|
EXAM 3 (8:00 – 11:30 AM)
Includes lectures from Wahls,
Crew & Zhang
|
|
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Thur, 11/08/07 |
GE21
|
Prokaryotic & Regulation of
prokaryotic translation
|
Angus MacNicol |
|
Tue,
11/13/07 |
GE22
|
Eukaryotic translation
|
Angus MacNicol |
|
Thur, 11/15/07 |
GE23
|
Regulation of eukaryotic
translation
|
Angus MacNicol |
|
Tue,
11/20/07 |
|
No
class
|
|
|
Thur, 11/22/07 |
|
THANKSGIVING BREAK
|
|
|
Tue,
11/27/07 |
GE24
|
Eukaryotic Differentiation & Development
|
Mari Davidson |
|
Thur, 11/29/07 |
GE25
|
Eukaryotic Differentiation & Development
|
Mari Davidson |
|
Tue,
12/04/07 |
|
EXAM 4 (8:00 – 11:30 AM)
Includes lectures from
MacNicol & Davidson
|
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