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Sung W. Rhee, Ph.D.
Assistant Professor

Sung W. Rhee, Ph.D.
PHD
University of Washington, 2003

Research Interests
Calcium and potassium channels on the surface membrane of vascular muscle cells control calcium influx and potassium efflux, respectively, and thereby regulate arterial diameters. My research interests are 1) using ion channel genes as therapeutic agents to normalize blood pressure, and 2) understanding molecular mechanisms that regulate traffic and expression of ion channels in vascular muscle cells during hypertension and related conditions. We use a wide range of techniques including molecular biology, biochemistry, viral gene transduction, patch clamp, vessel perfusion, confocal imaging, and in vivo microscopy.

E-mail
RheeSung@uams.edu


Selected Publications

Tobin AA, Joseph BK, Albarwani S, Al-Kindi HN, Madden JA, Nemetz LT, Rusch NJ, Rhee SW. Loss of cerebrovascular Shaker-type K+ channels: a shared vasodilator defect of genetic and renal hypertensive rats. Am J Physiol – Heart Circ Physiol, 297(1): H293-H303, 2009.

Rhee SW, Stimers JR, Wang W, Pang L. Vascular smooth muscle specific knockdown of non-cardiac form of L-type calcium channel by shRNA as a potential anti-hypertensive therapy. J Pharmacol Exp Ther, 329(2):775-82, 2009.

Marsh JD, Telemaque S, Rhee SW, Stimers JR, Rusch NJ. Delivery of ion channel genes to treat cardiovascular diseases. Trans Am Clin Climatol Assoc, 119:171-183, 2008.

Telemaque S, Sonkusare S, Grain T, Rhee SW, Stimers JR, Rusch NJ, Marsh JD. Design of mutant β subunits as decoy molecules to reduce the expression of functional Ca2+ channels in cardiac cells. J Pharmacol Exp Ther, 325 (1): 37-46, 2008.

Jiang S, Rhee SW, Gleeson P, Storrie B. Capacity of the Golgi apparatus for cargo transport prior to complete assembly. Mol Biol Cell, 17 (9): 4105-17, 2006.

Rhee SW, Starr T, Williams KF, Storrie B. The Steady-state distribution of glycosyltransferases between the Golgi apparatus and the endoplasmic reticulum is approximately 90:10. Traffic 6 (11): 978-990, 2005.


University of Arkansas for Medical Sciences
Department of Pharmacology and Toxicology

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