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Philip Palade, Ph.D.
Professor

Philip Palade, Ph.D.
PHD
University of Pennsylvania, 1976

Research Interests
The principal research interests in our laboratory involve the function and regulation of expression of the most abundant voltage gated calcium channel in the cardiovascular system. We have found that different promoters drive its expression in the heart and in blood vessels. This channel is the site of all therapeutic Ca channel blockers, which specifically target those channels in the blood vessels and can alleviate hypertension without affecting heart function. Unfortunately, Ca channel blockers are short lasting, and many patients fail to take their medication conscientiously. By focusing on regulatory sequences in the channel gene’s DNA and the mRNA it encodes, we hope to generate new compounds with longer lasting therapeutic effects that are still selective for the vasculature. In collaboration with Dr. Rusch's lab, we also wish to determine how hypertension is associated with greater Ca channel expression in vascular smooth muscle cells of the vessel wall.

E-mail
ppalade@uams.edu


Selected Publications

Palade, P. The hunt for an alternate way to generate NAADP. Focus on "NAADP as a second messenger: neither CD38 no base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells". Am. J. Phyisol. Cell Physiol. 292:C4-C7; 2007.

Sonkusare, S.; Palade, P.T.; Marsh, J.D.; Telemaque, S.; Pesic, A.; Rusch, N.J. Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications. Vasc. Pharmacol. 44, 131-142; 2006.

Wang, W.-Z.; Saada, N.; Dai, B.;Pang, L.; Palade, P. Vascular-specific increase in exon 1b-encoded Cav1.2 channels in spontaneously hypertensive rats. Am. J. Hypertension, 19:823-831; 2006.

Shi, X.-Z.; Pazdrak, K.; Saada, N.; Dai, B.; Palade, P.; Sarna, S.K. Negative transcriptional regulation of human colonic smooth muscle CaV1.2 channels by p50 and p65 subunits of NF-?B. Gastroenterology 129:1518-1532; 2005.

Saada, N.I.; Carillo, E.D.; Dai, B.; Wang, W.-Z.; Dettbarn, C.; Sanchez, J.; Palade, P. Expression of multiple CaV1.2 transcripts in rat tissues mediated by different promoters. Cell Calcium 37: 301-309, 2005.

Saada, N.; Dai, B.; Echetebu, C.; Sarna, S.K.; Palade, P. Smooth muscle uses another promoter to express primarily a form of human CaV1.2 L-type calcium channel different from the principal heart form. Biochem. Biophys. Res. Commun. 302: 23-28, 2003.

Dai, B.; Saada, N.; Echetebu, C.; Dettbarn, C.; Palade, P. A new promoter for the a1C subunit of the human L-type cardiac calcium channel CaV1.2. Biochem. Biophys. Res. Commun. 296:429-433, 2002.

Fan, J.-S.; Palade, P. Preferential loss of E-C coupling gradation at positive membrane potentials in rat ventricular myocytes. Pflugers Arch. 444: 654-662, 2002.

Ho, P.D.; Fan, J.-S.; Hayes, N.L.; Saada, N.; Palade, P.T.; Glembotski, C.C.; McDonough, P.M. Ras reduces L-type calcium channel current in cardiac myocytes: corrective effects of L-channels and SERCA2 on [Ca2+]i regulation and cell morphology. Circ. Res. 88:63-69, 2001.

View Dr. Palade's full PubMed publication list.


University of Arkansas for Medical Sciences
Department of Pharmacology and Toxicology

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