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W. Brooks Gentry, M.D.
Professor of Anesthesiology and Pharmacology

W. Brooks Gentry, M.D.
MD
University of Arkansas for Medical Sciences, 1988

Research Interests
The goal of my research is to develop therapeutic strategies for stimulant abuse, which alter the pharmacokinetic properties of these drugs. We are characterizing the pharmacokinetic and pharmacodynamic properties of two prototypic drugs of abuse (phencyclidine and methamphetamine) during the onset and offset of effects in animal models designed to mimic human drug use. The knowledge gained from these studies is being utilized in the development and testing of antibody-based medications, which alter the concentration vs. time profiles of drugs of abuse. These studies are part of a multidisciplinary, clinician scientist approach to the rational development of therapeutic strategies for the treatment of drug abuse. These preclinical studies will provide the background information necessary for translational (i.e., benchtop to bedside) research of the efficacy of antibody-based medications for the treatment of human drug abuse.

E-mail
gentrywilliamb@uams.edu

Selected Publications
McGaugh J, Mancino MJ, Feldman Z, Chopra MP, Gentry WB, Cargile C, and Oliveto A. Open Label Pilot Study of Modafinil for Methamphetamine Dependence. Journal of Clinical Psychopharmacology 2009 (in press).

Gentry WB, Rüedi-Bettschen D, Owens SM. Development of Active and Passive Human Vaccines to Treat Methamphetamine Addiction. Human Vaccines, 5:1-8, 2009.

Pitas G, Laurenzana EM, Williams DK, Owens SM, and Gentry WB. Anti-PCP Monoclonal Antibody Binding Capacity is not the Only Determinant of Effectiveness, Disproving the Concept that Antibody Capacity is easily Surmounted. Drug Metab Dispos, 34:906-912, 2006.

Gentry WB, Laurenzana EM, Williams DK, West JR, Berg RJ, Terlea T, and Owens SM. Safety and Efficiency of an Anti-(+)-Methamphetamine Monoclonal IgG in the Protection against Cardiovascular and Central Nervous System Effects of (+)-Methamphetamine in Rats. International Immunopharmacology, 6:968-977, 2006.

University of Arkansas for Medical Sciences
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