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Fang Zheng, Ph.D.
Associate Professor

Fang Zheng, Ph.D.
PHD
University of Texas Medical Branch at Galveston, Texas, 1994

Research Interests
My laboratory studies the regulation of glutamate receptors, an important family of neurotransmitter receptors. Glutamate receptors are involved in multiple neurological diseases, such as stroke-induced paralysis and cognitive dysfunction, epilepsy, and perhaps the debilitating consequences of Alzheimer’s disease, the neurological correlates of schizophrenia and AIDS. By better understanding these receptors, we will better understand the underlying causes of these diseases, and be better equipped to develop effective treatments for these serious conditions. My laboratory utilizes a multidisciplinary approach that utilizes molecular, biochemical, and electrophysiological techniques.

E-mail
zhengfang@uams.edu


Selected Publications

Zheng, F. and Gallagher, J. P. (1992) Metabotropic glutamate receptors are required for the induction of long-term potentiation. Neuron 9, 163-172.

Zheng, F. and Gallagher, J.P. (1995) Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in rat dorsolateral septal nucleus neurons. J. Neurosci. 15, 504-510.

Zheng, F., Gallagher, J.P. and Connor, J.A. (1996) Activation of a metabotropic glutamate receptor potentiates spike-driven calcium increases in neurons of the dorsolateral septum. J. Neurosci. 16, 6079-6088.

Zheng, F., Gingrich, M.B., Traynelis, S.F. and Conn, P.J. (1998) Tyrosine kinase potentiates NMDA receptor current by reducing tonic Zn2+ inhibition. Nature Neuroscience 1, 185-191.

Traynelis, S.F., Burgess, M.F., Zheng, F., Lyuboslavsky, P. & Powers, J.L. (1998) Control of voltage-independent zinc inhibition of NMDA receptors by NR1 subunit. J. Neurosci. 18,6163-6175.

Low, C.M., Zheng, F., Lyuboslavsky, P., Traynelis, S.F. (2000) Molecular determinants of coordinated proton and zinc inhibition of NR1/NR2A receptors. Proc. Nat. Acad. Sci. 97, 11062-11067.

Zheng. F., Erreger K., Low, C.M., Banke, T., Lee, J., Conn, P.J. & Traynelis, S.F. (2001) An allosteric interaction between the zinc-binding site and glutamate-binding site causes fast desensitization of NR1/NR2A receptors. Nature Neuroscience 4, 894-901.

Low, C.-M., Lyuboslavsky, P., French, A., Lee, P, Wyatte, K., Thiel, W.H., Marchan, E., Igarashi, K., Kashiwagi, K., Gernert, K., Williams, K., Traynelis, S.F.and Zheng, F. (2003) Molecular determinants of proton sensitive NMDA receptor gating. Mol. Pharmacol. 63, 1212-1222.

Hu, B. and Zheng, F. (2004) Differential effects on current kinetics by point mutations in the lurcher motif of NR1/NR2A receptors. J. Pharm. Exp. Theurap. (In press).


University of Arkansas for Medical Sciences
Department of Pharmacology and Toxicology

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