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Joseph R. Stimers, Ph.D.
Professor

Joseph R. Stimers, Ph.D.
PHD
University of Southern California, 1982

Research Interests
My research interests include: 1) the biophysics of excitable membranes especially ion channels and ion transport mechanisms; 2) physiology and pharmacology of cardiac muscle; and 3) the role of Na/K pump isoforms in peripheral nervous tissue. In my laboratory we are currently studying mechanisms that regulate the activity of the Na/K pump in cardiac myocytes using the whole patch clamp technique and fluorescent dyes. These studies are clinically relevant to congestive heart failure, hypertrophy and aging. We are also investigating the mechanism of action of phospholipid metabolites on ion channels in the heart which is relevant to a variety of inflammatory and ischemic processes. We have also recently begun using dorsal root ganglion neurons as a model system for studying Na/K pump junction and the role of its isoform. These studies are relevant to diabetic neuropathy and peripheral hyperalgesia.

E-mail
StimersJosephR@uams.edu

Selected Publications
Dobretsov, M., Hastings, S.L. and Stimers, J.R.: Na+-K+ pump cycle during b-adrenergic stimulation of adult rat cardiac myocytes. J. Physiol. (Lond.), 507:527-539, 1998.

Hicks, K.K., Seifen, E., Stimers, J.R. and Kennedy, R.H.: Effects of streptozotocin-induced diabetes on heart rate, blood pressure and cardiac autonomic nervous control. J. Autonomic Nervous System 69:21-30, 1998.

Dobretsov, M., Hastings, S.L. and Stimers, J.R.: Non-uniform expression of a subunit isoform of the Na+/K+ pump in rat dorsal root ganglia neurons. Brain Res. 821:212-217, 1999.

Dobretsov, M., Hastings, S.L. and Stimers, J.R.: Functional Na+/K+ pump in rat dorsal root ganglia neurons. Neuroscience 93:723-729, 1999.

Stimers, J.R., Dobretsov, M., Hastings, S.L., Jude, A.R. and Grant, D.F.: Effects of linoleic acid metabolites on electrical activity in adult rat ventricular myocytes. Biochim. Biophys. Acta 1438:359-368, 1999.

View Dr. Stimers' PubMed publication list.

University of Arkansas for Medical Sciences
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