College of Medicine College of Medicine

News/Events/Seminars
50th Anniversary Celebration
Faculty
History
Pharmacology Graduate Program
Interdisciplinary Toxicology Graduate Program
Available Courses
Postdoctoral Training
SURF Program
Meet Our Students
Contact Us
Faculty Positions
UAMS College of Medicine
UAMS Graduate School
UAMS Home
Department Homepage

Update Alumni



Victor M. Samokyszyn, Ph.D.
Associate Professor

Victor M. Samokyszyn, Ph.D.
PHD
Wayne State University, Ph.D., 1987

Research Interests
We are carrying out investigations of free radical mechanisms involved in retinoic acid oxidation, by enzymatic pathways (prostaglandin H synthase & cytochrome P-450) and by nonenzymatic mechanisms (peroxyl & alkoxyl radicals). We are also investigating mechanisms and bioorganic aspects of chlorophenol metabolic activation by mammalian peroxidases and human cytochrome P-450 isozymes.

E-mail
SamokyszynVictorM@uams.edu


Selected Publications

Samokyszyn, V.M., Chen, T., Maddipati, K.R., Franz, T.J., Lehman, P.A., and Lloyd, R.V. (1995) Free radical oxidation of (E)-retinoic acid by prostaglandin H synthase. Chem. Res. Toxicol. 8, 807-815.

Chang, H.C., Compadre, R.L., Lloyd, R.V., Freeman, J.P., and Samokyszyn, V.M. (1996) Nonenzymatic reduction of tetrachloro-1,4-benzoquinone by reduced nicotinamide adenine dinucleotide phosphate in an aqueous system. Biochem. Biophys. Res. Commun. 220, 1043-1048.

Freyaldenhoven, M.A., Lloyd, R.V., and Samokyszyn, V.M. (1996) Prostaglandin H synthase-catalyzed oxidation of all-trans- and 13-cis-retinoic acid to carbon-centered and peroxyl radical intermediates. Chem. Res. Toxicol. 9, 677-681.


University of Arkansas for Medical Sciences
Department of Pharmacology and Toxicology

4301 West Markham Street, Slot 611
Little Rock, AR 72205
(501) 686-5510
Contact: Webmaster.