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Martin J. J. Ronis, Ph.D.
Professor

Martin J. J. Ronis, Ph.D.
PHD
Reading University, England, 1985

Research Interests
My research program is split into two parts related to developmental toxicology and to health consequences related to early nutrition. We have been funded by NIH to develop and characterize a series of in vivo animal models of drug and pollutant toxicity, with a particular emphasis on developmental exposures. More recently we have concentrated on development of rodent models for alcohol metabolism and toxicity in pregnancy and for fetal alcohol syndrome.These projects involve multidisciplinary basic science studies encompassing whole animal physiology, nutrition and endocrinology; pathology, neuroendocrinology, sex steroid biochemistry, cytochrome P450 biochemistry and molecular biological techniques. The goal of these studies is the better understand molecular basis for the toxic actions of alcohol, drugs and pollutants which might uncover theraputic targets and to determine the effects of nutritional status on pathological outcomes in exposed populations. In a second project at the Arkansas Children’s Nutrition Center we are funded by the USDA-ARS Human Nutrition Program to examine effects of early nutrition on development of long-term chronic diseases of adulthood and on the metabolism and efficacy of pediatric medications.

E-mail
ronismartinj@uams.edu


Selected Publications

Ronis M.J.J., Badger, T.M. Chen, Y. and Badeaux J, Early soy consumption results in improved insulin sensitivity and lipid homeostasis associated with activation of PPAR and LXR-mediated pathways and inhibition of SREBP-1c activation in rat liver, J. Nutr. (In Press) (2009).

Wahl EC, Aronson J, Liu L, Fowlkes JL, Thraikill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Isales CM, Badger TM, Ronis MJJ, Sims J and Lumpkin CKJr. Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF. J. Bone Min. Res. (In Press) (2009).

Singhal R., Shankar K., Badger T.M. and Ronis M.J.J. Soy protein isolate mediated hepatic gene expression differs from that of 17β-estradiol in female rats, J. Endocrinol. 202: 143-154, 2009.

Badger T.M., Gilchrist J.M., Pivik R.T., Andres A., Shankar K., Chen J.R.and Ronis M.J.J., The health implications of soy infant formula. Am. J. Clin. Nutr. 89: S1-S5, 2009.

Chen J-R, Lazarenko OP, Haley RL, Blackburn ML, Badger T.M. and Ronis M.J.J. Ethanol impairs estrogen receptor signaling and activates senescence pathways in osteoblasts. Protection by estradiol. J. Bone Min. Res. 24: 221-230, 2009.

Singhal R., Badger T.M. and Ronis M.J.J. Estrogenic status modulates the effects of soy on hepatic responses to 7,12-dimethylbenz(a)anthracene (DMBA), Toxicol. Appl. Pharmacol. 234:89-97, 2009.

View Dr. Ronis' PubMed publication list.


University of Arkansas for Medical Sciences
Department of Pharmacology and Toxicology

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