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Philip R. Mayeux, Ph.D.
Professor and Director of Education

Philip R. Mayeux, Ph.D.
PHD
Tulane, 1987

Research Interests
Acute renal failure is a frequent and serious complication of septic shock in humans. My research is focused on the study of animal models of renal injury associated with sepsis. Studies are directed toward understanding the biochemical and physiological mechanisms triggered by sepsis that lead to cellular injury and organ failure. Our primary interests are in understanding the development of oxidant stress caused by reactive oxygen and nitrogen species as mediators of renal injury and evaluating new therapeutic approaches to prevent renal injury or accelerate recovery.

E-mail
prmayeux@uams.edu


Selected Publications

Herzog, C., Haun, R.S., Kaushal, V., Mayeux, P.R., Shah, S.V., and Kaushal, G.P.: Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta. Biochem. Biophys. Res. Commun. 379:904-904, 2009.

Mikhailova, M.V., Blansett, J., Jacobi, S., Mayeux, P.R., and Cornett, L.E.: Transmembrane domain IV of the Gallus gallus VT2 vasotocin receptor is essential for forming a heterodimer with the corticotrophin releaseing hormone receptor. J. Biomed. Opt. 13(3):031208, 2008.

Wu, L. Gokden, N., and Mayeux, P.R.: Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced peritubular capillary dysfunction and tubular injury. J. Am. Soc. Nephrol. 18:1807-1815, 2007.

Wu, L. and Mayeux, P.R.: Effects of the inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl)-lysine on microcirculation and reactive nitrogen species generation in the kidney following lipopolysaccharide administration in mice. J. Pharmacol. Exp. Ther. 320:1061-1067, 2007.

Wu, L., Tiwari, M.M., Messer, K.J., Holthoff, J.H., Gokden, N., Brock, R.W., and Mayeux, P.R.: Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice. Am. J. Physiol. Renal Physiol. 292:F261-F268, 2007.

Tiwari, M.M., Stimers, J.R., and Mayeux, P.R.: Bradykinin-induced calcium-independent chloride conductance in murine proximal tubular epithelial cells. Mol. Cell. Biochem. 297:1-8, 2007.

Tiwari, M.M., Messer, K.J., and Mayeux, P.R.: Inducible nitric oxide synthase and apoptosis in murine proximal tubule epithelial cells. Toxicol. Sci. 91:493-500, 2006.

View Dr. Mayeux's PubMed publication list.


University of Arkansas for Medical Sciences
Department of Pharmacology and Toxicology

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