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Lee Ann MacMillan-Crow, Ph.D.
Associate Professor and Director, Interdisciplinary Toxicology Graduate Program

Lee Ann MacMillan-Crow, Ph.D.
PHD
University of Alabama at Birmingham, 1994

Research Interests
One goal of our laboratory is to determine the role that increased oxidant production has on the early events leading to renal dysfunction following cold preservation and I/R in vivo. We have previously demonstrated endogenous tyrosine nitration and inactivation of manganese superoxide dismutase (MnSOD) in both human and rat chronic renal allograft rejection. The net result of loss of MnSOD activity is damage to sensitive electron transport systems and an accompanying increase in oxidant production, thus amplifying further cellular injury. More recent studies using an in vivo rat kidney I/R model also suggest that MnSOD is tyrosine nitrated early during renal I/R injury. Another goal of the lab is to define the relative contribution of altered MnSOD activity and oxidative stress on I/R related injury using normal rat kidney proximal tubular cells in vitro or novel kidney specific transgenic (Cre/Lox) mice in vivo. Finally, one major goal of our lab is to assess the therapeutic potential of known and novel antioxidants to alter I/R and transplantation induced renal dysfunction.

E-mail
LMCrow@uams.edu

Selected Publications
S. Munusamy and L.A. MacMillan-Crow. Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells. Free Radical Biology and Medicine, 46:1149-1157, 2009.

S. Munusamy, H. Saba, T. Mitchell, J. Megyesi, R.W. Brock, and L.A. MacMillan-Crow. Alteration of Renal Respiratory Complex-III during Experimental Type-1 Diabetes. Endocrine Disorders, 9:2, 2009.

H. Saba, S. Munusamy, and L.A. MacMillan-Crow. Cold Preservation Mediated Renal Injury: Involvement of Mitochondrial Oxidative Stress. Renal Failure, 30:1-9, 2008.

H. Saba, I. Batinic-Haberle, S. Munusamy, T. Mitchell, C. Lichti, J. Megyesi, and L.A. MacMillan-Crow. Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. Free Radical Biology and Medicine, 42(10): 1571-1578, 2007.

Cruthirds DL, Novak L, Ahki KM, Sanders PW, Thompson JA, MacMillan-Crow LA. Mitochondrial targets of oxidative stress during renal ischemia/reperfusion. Archives of Biochemistry and Biophysics 412(1): 27-33, 2003.

MacMillan-Crow LA, Cruthirds DL. MnSOD in disease. Invited Review: Free Radical Medicine 34: 325-336, 2001.

MacMillan-Crow LA, Crow JP, Kerby JD, Beckman JS, Thompson JA. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human allografts. Proceedings of the National Academy of Sciences (USA) 93: 11853-11858, 1996.

View Dr. MacMillan-Crow's PubMed publication list.

University of Arkansas for Medical Sciences
Department of Pharmacology and Toxicology
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