UAMS Department of Pathology - Residency Program Information
Rotation Descriptions
Surgical Pathology
Over 35,000 surgical specimens a year between three hospitals.
Advanced techniques are available
including immunohistochemistry, in situ
hybridization, electron microscopy, flow cytometric analysis of ploidy, tumor
chromosomal analysis, and DNA sequencing.
Modern research-oriented laboratories exist for both electron microscopy and advanced immunocytochemical techniques.
Autopsy Pathology
180 medical autopsies a year
1,000 forensic autopsies
Major funded research programs in Alzheimer's disease and bone marrow transplantation rely on prompt and reliable collection
of postmortem tissues, and on correlation of research findings with thorough
pathological examinations.
Dermatopathology
Over 12,000 specimens and 300 direct immunoflouresence specimens are processed each year.
This rotation is a minimum of a 3 months.
Nephropathology
Biopsies for diagnosis in this area are evaluated by light
microscopy, immunofluorescence, and electron microscopy.
Research topics include renal diseases.
Neuropathology
Over 300 neurosurgical specimens (excluding herniated
discs) are received per year, including 50 pediatric neurosurgical specimens
and 100 muscle and nerve biopsies.
Research topics include involvement of glial cytokines in various chronic neurological diseases.
Immunopathology and Molecular Biology
3,000 specimens processed per year, primarily hematopoietic and other neoplasms.
These include monoclonal antibody
immunohistochemistry, flow cytometry, gene rearrangement, polymerase chain reaction
and fluorescent in situ hybridization.
The acquisition of a state-of-the
art DNA sequencing machine provides the capability to analyze size and sequence
of DNA or DNA fragments.
Cytopathology and Fine Needle Aspiration
The UAMS cytology service evaluates approximately 15,000 gynecologic and nongynecologic
cytological specimens and fine needle aspiration specimens per year.
Residents participate in all aspects of the
service, including performance of needle aspiration procedures at the bedside
and on-site rapid evaluation of radiographically directed aspirations.
Selected
cases are evaluated by immunohistochemistry, electron microscopy, and flow cytometry.
Review of subsequent surgical biopsies in patients receiving cytological examinations
is an important part of the rotation.
Pediatric Pathology
Arkansas Children's Hospital is the 6th largest Children's Hospital in
the country, and was recently recognized as one of the top training programs
in pediatrics nationwide.
The Pathology Department at ACH processes approximately 5,000 surgical specimens,
50 autopsies, and 500,000 clinical pathology specimens a year.
All residents receive a basic experience
in pediatric anatomical and clinical pathology.
Forensic Pathology
The Arkansas Medical Examiner's Office conducts approximately 1,000 forensic
autopsies a year, including 150 homicide cases and over 100 pediatric cases,
the latter primarily cases of child abuse, SIDS ("crib death") and
other commonly encountered conditions.
Specialized techniques are available
in toxicology, serology, anthropology and other disciplines.
A rotation in forensic
pathology for all residents includes on-scene investigation of traumatic deaths
and court attendance during expert medical testimony.
Research programs are
pursued in collaboration with UAMS affiliated hospitals and with the National
Center for Toxicological Research near Pine Bluff, Arkansas.
Laboratory Hematology and Hematopathology
Therapy of hematopoietic malignancies, especially multiple myeloma, is a major
clinical program at UAMS, and the UAMS hematopathology program is one of the
largest such services in the nation. Approximately 125 autologous/allogeneic
bone marrow transplants, 450 CD34-enriched peripheral blood harvests, and 6,000
bone marrow biopsies are processed each year.
A new T cell-depleted bone marrow transplantation program is in place. Bone marrow procedures are performed by Department of Pathology staff
and residents.
Specialized training is available in molecular diagnostics, flow cytometric techniques,
cytogenetics and immunohistochemistry.
Laboratory Practice Management
Provides an awareness and reponsiveness to the larger context and system of healthcare and the ability to effectively call on system resoures to provide care that is of optional value.
Includes CAP Virtual Management College teleconferences
Didactic component including a mangement project for presentation, past topics have included new laboratory test design, denial research, billing inquires, quality assurance activities, outreach, and laboratory management manual/policy reviews.
Mentoring in the rotation provided by medical and business professionals
Blood Banking and Apheresis
The blood bank of the University Hospital offers the pathology resident
an integrated educational experience in clinical and laboratory transfusion
medicine.
The blood bank draws 10,000 donors per
year, of which 2,500 are platelet apheresis donors.
20,000 crossmatches
support 2,300 transfusion events per year.
Over 250 therapeutic procedures per
year treat patients with hematologic and neurologic disorders.
We are the largest autologous transplant program in the country. We are one of the few apheresis units to have private rooms.
Special Coagulation
A wide variety of clinical
problems involving either hypocoagulable or hypercoagul
able states are referred
to the laboratory.
The clinical pathology residents are intimately involved
in correlating laboratory and clinical findings and preparing consultative reports.
Research topics include hemostasis and coagulation.
Cytogenetics and Molecular Pathology
Chromosomal analysis of blood, bone marrow, amniotic fluid, chorionic villi,
products of conception, solid tissue and solid tumors is performed in a modern
state-of-the-art laboratory located at Arkansas Children's Hospital.
12 full-time cytogenetic technologists process over 2,900 specimens
annually. This volume of material yields many rare and unusual cases, as well
as ample examples of common cytogenetic aberrations. Modern image-analysis and
computer karyotyping systems are used to interpret results.
Fluorescent in situ
hybridization, an advanced research-oriented technique, is available for the
identification of low level chromosomal mosaicism related to minimal residual
disease, identification of gene rearrangements and gene amplification.
A variety
of tests using molecular biological techniques, such as PCR, are in use for
the diagnosis of viral diseases, other genetic diseases, and for classifying
certain malignancies.
UAMS
Department of Pathology
4301 West Markham #517
Little Rock AR 72205
501-686-5170
Bruce Smoller, M.D., Chair
For general information or questions about the Department of Pathology
you may contact Linda DePriest, Executive Assistant to the Department Chair. For web page issues you may contact the
.