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Kumuda C. Das, PhD
Associate Professor of Pathology
Kumuda C. Das, PhD PhD
Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA

Research Interests
Oxidative Stress and Redox Control of Gene Expression, Redox Control of Cell Cycle Regulation, and Mechanisms of Redox-Cycling of Anthracycline Class of Antitumor Agents.



Email: kdas@uams.edu



Selected Publications
Muniyappa, H. B., Song, S., Mathews, CK. and Das, K. C. 2009. Reactive Oxygen Species-independent Oxidation of Thioredoxin in Hypoxia: Inactivation of Ribonucleotide Reductase and Redox-mediated Checkpoint Control. J Biol Chem 284:17069-17081.

Kulkarni, A. and Das, K. C. 2008. Differential roles of ATR and ATM in p53, Chk1 and histone H2AX phosphorylation in response to Hyperoxia: ATR-dependent ATM activation. Am J Physiol Lung Cell Mol Physiol.294:L998-L1006.

Muniyappa, H. B.,and Das, K. C. 2008. Activation of c-Jun N-Terminal Kinase (JNK) by widely used specific p38 MAPK inhibitor SB202190 and SB203580: A MLK-3-MKK7-dependent mechanism. Cell Signal 20:675-683.

Dashnamoorthy R., and Das, K. C. 2008. Caffeine inhibits UV-mediated NF-kB activation: An ATM-PKCd-p38 MAPK-dependent mechanism. Mol Cell Biochem 308:193-200.

Dashanamoorthy, R. and Das, K.C. 2005.Thioredoxin increases anthracycline redox-cycling and sensitizes breast cancer cells to p53-dependent apoptosis. J Biol Chem. 280, 40084-40096

Das, K.C. 2005. Thioredoxin, and its role in premature newborn biology, Antioxid. Redox Signal. 7, 1740-1743


UAMS Department of Pathology
4301 West Markham #517
Little Rock AR 72205
501-686-5170
Bruce Smoller, M.D., Chair

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