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Anatomic Pathology
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Thomas J. Kelly, Jr., PhD
Associate Professor of Pathology
Thomas J. Kelly, Jr., PhD PhD
University of North Carolina Chapel Hill

Post Doctoral Training
Georgetown Medical Center, Washington, DC

Major Interests
Basic Research

Research Interests
Role of cell surface proteases, such as seprase in breast cancer cell growth, invasion and metastasis. Understanding the cellular and molecular mechanisms of tumor cell invasion and metastasis.



Email: KellyThomasJ@uams.edu



Selected Publications
Huang, Y., S. Wang, and T. Kelly (2004) Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer. Cancer Res. 64:2712-2716.

Yang, Y., V. MacLeod, M. Bendre, Y. Huang, A. M.Theus, H.-Q. Miao, P. Kussie, S. Yaccoby, J. Epstein, L. J. Suva, T. Kelly and R. D. Sanderson (2005) Heparanase promotes the spontaneous metastasis of myeloma cells to bone. Blood 105:1303-1309.

Kelly, T. (2005) Fibroblast activation protein-รก and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. Drug Resistance Updates: 8:51-58.

Kelly, T., L. J. Suva, Y. Huang, V. MacLeod, H.-Q. Miao, R. C. Walker, and R. D. Sanderson (2005) Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Res., 65:5778-84.

T. Kelly, E. A. Coleman, E. Kim Fifer, E. Robert Burns, C. Orr, and R.W. Nicholas (2006) Partners in research: benefits of a summer research program. J. Cancer Ed. 21:243-7.

Naito, A., T. Mizumachi, M. Wang, C.-H. Xie, T. T. Evans, T. Kelly, and M. Higuchi, (2008) Progressive Tumor Features Accompany Epithelial-Mesenchymal Transition Induced in Mitochondrial DNA Depleted Cells. Cancer Sci.99:1584-8.

Galanzha, E. I., E. V. Shashkov, T. Kelly, Jin-Woo Kim, Lily Yang, and Vladimir P. Zharov. (2009) In vivo integrated magnetic enrichment and photoacoustic detection of circulating tumor cells multiplex targeted with magnetic and gold nanoparticles. Nature Nanotechnology, In press


UAMS Department of Pathology
4301 West Markham #517
Little Rock AR 72205
501-686-5170
Bruce Smoller, M.D., Chair

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