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Faculty
David L. Davies, Ph.D.
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Title
Associate Professor
PhD
Louisiana State University Medical Center, New Orleans
Post Doctoral Training
University of Colorado Health Sciences Center, Denver
Research Interests
Our work focuses on the pathogenesis of developmental and neurodegenerative disorders resulting from substance abuse. Specifically, the laboratory is engaged in studies designed to determine the extent to which acute and chronic alcohol use alters the repair of cerebral tissue in the aftermath of traumatic injury. Cerebral cell and organotypic cultures, in vivo models are used to assess the responses of astrocytes and microglia to cytokines and/or alcohol. These studies endeavor to provide basic information regarding the cascade of cell proliferative and reactive mechanisms elicited at the site of brain lesions resulting from traumatic injury. Since alcohol abuse is a predisposing factor for trauma, an understanding of the influence of alcohol on the metabolism and reactivity of glial cells will be beneficial for the design of appropriate clinical treatment protocols.
Dr. Davies also lectures in the Human Gross Anatomy course and is Co-Director of the Cellular and Developmental Neuroscience graduate course.
Email: daviesdavidl@uams.edu
Address: Office: Shorey 8/11
Mailing address: University of Arkansas for Medical Sciences
4301 West Markham St., Slot 510
Little Rock, AR 72205
Phone: 501-686-5184
Pub Med
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| Selected Publications |
| Kane, C.J.M., Boop, F.A. and Davies, D.L. (1996) Proliferation of astroglia from the adult human cerebral cortex is inhibited by ethanol in vitro. Brain Res. 731:39-44. Bowyer JF, Davies DL. (1999) Changes in mRNA levels for heat-shock/stress proteins (Hsp) and a secretory vesicle associated cysteine-string protein (Csp1) after amphetamine (AMPH) exposure. Ann. NY Acad. Sci. 890:314-329. Kwon OS, Slikker W Jr, Davies DL. (2000) Biochemical and morphological effects of fumonisin B(1) on primary cultures of rat cerebrum. Neurotoxicol. Teratol. 22:565-572. Davies DL, Niesman IR, Boop FA, Phelan KD. (2000) Heterogeneity of astroglia cultured from adult human temporal lobe. Int. J. Dev. Neurosci. 18:151-160. |
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