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W. Sue T. Griffin, Ph.D.
W. Sue T. Griffin, Ph.D. Title
Professor and Vice Chairman for Research The Donald W. Reynolds Department of Geriatrics

PhD
Rochester, New York

Major Interests
Molecular biology of Alzheimer’s disease.

Research Interests
Dr. Griffin focuses on the mechanisms involved in the progression of Alzheimer's Disease. Recently, Dr. Griffin has discovered a link between the presence of a certain immuno-response-generated cytokine, Interleukin-1, and the increased probability of onset of Alzheimer's Disease. This is seen as a significant breakthrough in the early detection and treatment of Alzheimer's, and it has drawn nationwide acclaim for Dr. Griffin and the Donald W. Reynolds Department of Geriatrics.

Email: GriffinSueT@uams.edu

Address: Office: Reynolds Center on Aging, Room 3103 Mailing address: Department of Geriatrics #807 University of Arkansas for Medical Sciences 629 Jack Stephens Dr., Little Rock, AR 72205

Phone: (501) 526-5800

Fax: (501) 526-5830

UAMS Dept. of Geriatrics


Selected Publications
Sheng JG, Mrak RE, Jones RA, Brewer MM, Zhou XQ, McGinness J, Woodward S, Bales K, Paul SM, Cordell B, Griffin WST. 2001 Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice. Neurobiol Aging 22:895-902.

Mrak RE, Griffin WST. 2001 Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol Aging. 22:903-908.

Griffin WST, Mrak RE 2002 Interleukin-1 in the genesis and progression of, and risk for development of neuronal degeneration. J Leukoc Biol 72:233-238.

Butterfield DA, Griffin S, Munch G, Pasinetti GM. 2002 Amyloid ß-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer’s disease brain exists. J Alzheimer’s Dis 4:193-201.

Culpan D. MacGowan SH. Ford JM. Nicoll JA. Griffin WS. Dewar D. Cairns NJ. Hughes A. Kehoe PG. Wilcock GK. 2003 Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. Neurosci Lett. 350:61-65.

Li Y, Liu L, Barger SW, Griffin WST. 2003 Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway. J Neurosci 23:1605-1611.

Li Y, Liu L, Barger SW, Griffin WST. 2004 Microglial activation by uptake of fragmented DNA via a scavenger receptor. J Neuroimmunol 147:5050-5055.

Wu S, Bodles AM, Porter MM, Griffin WST, Basile AS, Barger SW 2004 Potential Role for D-serine in Alzheimer's disease. J Neuroinflammation 1:2.

Griffin WST, Mrak RE. 2004 Cytokines and their potential as biomarkers: relevance to Down's syndrome. J Policy Practices Cognitive Disorders (in press).

Mrak RE, Griffin WST 2004 Glia and Their Cytokines in Progression of Neurodegeneration. Neurobiol Aging (in press).

Mrak RE, Griffin WST 2004 Trisomy 21 and Brain. J Neuropathol Exp Neurol 63:679-685.

Wainwright MS, Craft JM, Griffin WST, Marks A, Pineda J, Padgett KR, Van Eldik, LJ 2004 Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia. Ann Neurol 56:61-67.

Gentleman SG, Leclercq PD, Moyes L, Graham DI, Smith C, Griffin WST, Nicoll JAR. 2004 Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Intl (in press)

Li Y, Liu L, Barger SW, Griffin WST. 2004 S100B-induced microglial and neuronal IL-1 expression is mediated by cell-specific nuclear transcription factors. J Neurosci (submitted).



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