Cynthia (Cindy) J.M. Kane, Ph.D. - Faculty - Department of Neurobiology and Developmental Sciences - University of Arkansas for Medical Sciences


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Cynthia (Cindy) J.M. Kane, Ph.D.
Title Professor PhD Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR Post Doctoral Training Dept. of Medicine, University of California, San Francisco, CA Dept. of Dermatology, Stanford University, CA Dept. of Biological Sciences, Stanford University, CA Research Interests Our studies focus on interactions between neurons and glia in the brain. The role of neuroprotective and neurotoxic molecules secreted by microglia and astrocytes in neuronal proliferation, survival and function is being defined. Mechanisms that control these interactions including cell-surface receptors, intracellular signal transduction pathways, and gene and protein expression are being identified. This laboratory has discovered that ethanol exposure during brain development disrupts specific interactions between microglia and neurons. Mechanistic analyses of the molecular targets of ethanol in the developing brain have led to new strategies for pharmacological intervention in the neuropathology of Fetal Alcohol Syndrome and Alcohol-Related Neurodevelopmental Disorder. Email: kanecynthiaj@uams.edu Address: Office: Shorey Building, room S8/33 Mailing address: Department of Neurobiology & Developmental Sciences University of Arkansas for Medical Sciences 4301 W. Markham, # 846 Little Rock, AR 72205 Phone: 501-686-7022 Fax: 501-686-6382

Selected Publications

Light, K.E., D.P. Brown, B.W. Newton, S.M. Belcher and C.J.M. Kane [2002] Ethanol-Induced Alterations of Neurotrophin Receptor Expression on Purkinje Cells in the Neonatal Rat Cerebellum. Brain Research 924:71-81

Carter, C.A., D.G. Jolly, C.E. Worden, D.G. Hendren and C.J.M. Kane [2003] Platelet Rich Plasma Gel Promotes Differentiation and Regeneration During Equine Wound Healing. Experimental and Molecular Pathology 74:244-255

Carter, C.A. and C.J.M. Kane [2004] Therapeutic potential of natural compounds that regulate the activity of protein kinase C. Current Medicinal Chemistry 11:2883-2902

Kossover, C.L. and C.J.M. Kane [2005] Alcohol Increases Microglial Expression of Chemokine MIP-1 and MCP-1 mRNA. Journal of the Arkansas Academy of Science 58:74-83

Syapin, P.J., W.F. Hickey, H. Kettenman and C.J.M. Kane [2005] Alcohol brain damage and neuroinflammation: Is there a connection? Alcoholism Clinical and Experimental Research 29:1080-1089.

Kane, C.J.M., E.R. Burns, P.S. O’Sullivan, T.J Hart, J.R. Thomas and I.A. Pearsall [2007] Design, Implementation, and Evaluation of the Transition from paper and Pencil to Computer Assessment in the Medical Microscopic Anatomy Curriculum. Journal of the International Association of Medical Science Educators 17:85-91.

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