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Jason Y. Chang, Ph.D.
Jason Y. Chang, Ph.D. Title
Associate Professor of Neurobiology & Developmental Sciences, Ophthalmology

PhD
Ohio State University

Post Doctoral Training
Washington University, St. Louis, MO

Research Interests
Oxidative stress, programmed cell death, neurotoxicity of cholesterol oxides and mercury.

Email: changjasony@uams.edu

Address: Office: Shorey 924
Mailing address: University of Arkansas for Medical Sciences
4301 W. Markham, slot 510
Little Rock, AR 72205

Phone: 501-686-7025

Fax: 501-686-6382


Selected Publications
1. Chang, J.Y. and Liu, L.Z. Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death. BMC Pharmacology 2001, 1:10 http://www.biomedcentral.com/1471-2210/1/10

2. Chang, J.Y. and Phelan K.D. The effects of oxysterols on cells of the nervous system. In: Sterols and oxysterols: Chemistry, Biology, and Pathology (2002). page 175-200. Editor: S. J. Fliesler, Research Signpost, Kerala, India http://www.uams.edu/neuroscience_cellbiology/faculty_pages/changphelanpub.htm

3. Garg, T.K. and Chang, J.Y. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: Prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmology 2003, 3:5 http://www.biomedcentral.com/1471-2415/3/5

4. Garg, T.K. and Chang, J.Y. 15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. BMC Pharmocol. 2004:4:6 http://www.biomedcentral.com/1471-2210/4/6

5. Garg, T.K. and Chang, J.Y. Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. J Neuroimmunol. 2006;171(1-2):17-28. http://www.jni-journal.com/article/PIIS0165572805004121/abstract



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