M. Donald Cave, Ph.D - Faculty - Department of Neurobiology and Developmental Sciences - University of Arkansas for Medical Sciences


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M. Donald Cave, Ph.D
Title Professor Emeritus Post Doctoral Training Postdoctoral Fellowships, Genetics Institute, Lund Sweden and Max-Planck-Institute, Tubingen, West Germany. Major Interests Probes for the diagnosis and molecular epidemiology of diseases caused by bacterial pathogens Research Interests M. Donald Cave's work is directed towards the development of molecular biology based tests for microbial pathogens. Particularly he has been involved in development of tests for mycobacterial pathogens (e.g. Mycobacterium tuberculosis) and for certain food-borne pathogens (e.g. Salmonella spp. and Campylobacter spp). In collaboration with K. D. Eisenach, Ph.D. (Dept. of Pathology) and J.H. Bates, M.D. (Arkansas Department of Health) a rapid test for identifying M. tuberculosis in clinical samples and a means for fingerprinting strains of M. tuberculosis have been developed. Currently he is carrying out a molecular epidemiology studies to determine the sources of Salmonella in patients with Salmonellosis. He teaches cell and basic tissue biology in the Medical Cell Biology course which is taught to freshman medical students. Curriculum Vitae: Word Email: dcave@uams.edu Address: Office: Shorey Building 922 Mailing Address:Department of Neurobiology and Developmental Sciences, #510 University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199 Phone: 501-686-5165 Fax: 501-296-1267

Selected Publications

Dickins, A. M., Franklin, S., Stefanova, R., Schutze, G. E. Eisenach, K. D., Wesley, I., and Cave, M.D. 2002. Diversity of Campylobacter Isolates from Retail Poultry Carcasses and from Humans as Demonstrated by Pulsed Field Gel Electrophoresis. J. Food Protection 65, 957-962.

Barnes, P. F. and Cave, M.D. 2003. Molecular epidemiology of tuberculosis: relevance to disease control and pathogenesis. New England Journal of Medicine 249, 1149-1156.

Theus, S.A., Cave, M. D.and Eisenach, K.D. 2005. Intracellular macrophage growth rates and cytokine profiles of M. tuberculosis strains with different transmission dynamics. J. Infect Dis. 191, 453-460.

M.D. Cave, Yang, ZH, Stefanova, R., Fomukong, N., Ijaz, K., Bates, J., and Eisenach K.D. 2005. Epidemiologic import of tuberculosis cases whose isolates have similar but not identical IS6110 RFLP patterns. J. Clin. Microbiol 43, 1228-1233.

Filliol I, Motiwala, AS, Cavatore, M, Qi, W, Hazbón, M, Bobadilla del Valle, M, Fyfe, J, García-García, L, Rastogi, N, Sola, C, Brudey, K, Zozio, T, Guerrero, MI, Leon, CI, Crabtree, J, Angiouli, S, Eisenach, KD, Durmaz, R, Joloba, M, Rendon, A, Sifuentes-Osornio, J, Ponce de León, A, Cave, MD, Fleischmann, R, Whittam, TS, and Alland, D. 2006. Global Phylogeny of Mycobacterium tuberculosis based on Single Nucleotide Polymorphism (SNP) Analysis: Insights into Tuberculosis Evolution, Phylogenetic Accuracy of other DNA Fingerprinting Systems, and Recommendations for a Minimal Standard SNP Set. J. Bacteriology 188, 759-772.

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