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Nalini S. Bora
Professor Department of Ophthalmology and Department of Microbiology & Immunology Director of Research, Pat & Willard Walker Eye Research Center Immunology Research Interest: Innate & Autoimmunity in ocular diseases (Age-related macular degeneration, uveitis, ocular tumors etc.) Ph.D. , All India Institute of Medical Sciences, New Delhi, India Postdoctoral , Washington University School of Medicine, St. Louis, MO Phone: (501) 686-8293 Fax: (501) 686-8316 Research Description My research is focused upon the understanding of biochemical, immunological and molecular mechanisms of various ocular disease such uveitis, age-related macular degeneration (AMD), keratitis and ocular tumors. My laboratory is first to demonstrate the importance of innate immune response (i.e. Complement System) in the protection of normal ocular tissues against infection as well as in systemic tolerance after the introduction of an antigen in the anterior segment of the eye. For the first time my laboratory provided an important link between innate immunity and ocular auto-immunity using an animal model of idiopathic anterior uveitis. Furthermore, we were first to demonstrate that the activation of complement system is crucial for the development of choroidal neo-vascularization (CNV) in wet-type AMD and keratitis. Currently, my laboratory is investigating the role of innate immune response in the survival and metastasis of ocular tumors. References Bora, N.S., Kaliappan, S., Jha, P., Xu, Q., Sivasankar, B., Harris, C.L., Morgan, B.P. and Bora, P.S. CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in Wet-type Age-related Macular Degeneration. Journal of Immunology, 178: 1783 – 1790, 2007 Jha, P., Bora, P.S., Sohn, J.H., Kaplan, H.J and Bora, N.S. 2006. Complement system and the eye (Review article). Advances in Experimental Medicine and Biology, 586: 53-62. Bora, N.S. , Kaliappan, S., Jha, P., Qin, X. Sohn, J. H., Dhaulakhandi, D.B., Kaplan H.J. and Bora, P.S. 2006.Complement Activation via Alternative Pathway is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H. J of Immunology, 177: 1872-1878. Jha, P., Sohn, J.H., Qin X, Wang, Y., Kaplan, H.J., Bora P.S., and Bora, N.S. 2006. Suppression of Complement Regulatory Proteins (CRPs) Exacerbates Experimental Autoimmune Anterior Uveitis (EAAU). J of Immunology, 176: 7221-7231. Jha, P., Sohn, J.H., Qin, X., Nishihori, H., Wang, Y, Nishihori, S., Manickam, B., Kaplan, H.J, Bora, P.S. and Bora, N.S. 2006. The Complement system plays a critical role in the development of experimental autoimmune anterior uveitis (EAAU). Invest Ophthalmol Vis Sci, 47: 1030-1038. Bora, P.S., Sohn J.H., Cruz, J.M.C., Jha, P, Nishihori, H., Wang, Y., Kaliappan, S., Kaplan, H.J. and Bora, N.S. 2005. Role of complement and complement membrane Attack complex in laser-induced choroidal neo-vascularization. J Immunol, 174: 491-497. Bora, P.S., Hu, Z., Tezel, T.H., Sohn, J.H., Kang, S.G., Cruz J.M.C., Bora, N.S, Garen, A and Kaplan, H.J. 2003. Immunotherapy for choroidal neovascularization in a laser induced mouse model simulating exudative (wet) macular degeneration. Proc. Natl. Acad. of Sci. USA., 100: 2679-2684. Sohn, J.H., Bora, P.S., Suk, J.H., Molina H., Kaplan H.J. and Bora, N.S. 2003. Tolerance is dependent on complement fragment iC3b binding to antigen presenting cells. Nature Medicine. 9: 206-212. Sohn, J-H, Kaplan, H.J., Suk H-J, Bora, P.S. and Bora, N.S. 2000. Complement-inhibitory activity of normal human intraocular fluid is caused by soluble forms of MCP, DAF and CD59. Invest Ophthalmol Vis Sci. 41: 4195 –4202. Sohn, J-H, Kaplan, H.J., Suk, H-J, Bora, P.S. and Bora, N.S. 2000. Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. Invest Ophthalmol Vis Sci. 41: 3492 – 3502. Bora,N.S., Kim, M.C., Kabeer,N.H., Simpson,S.C., Tandhasetti,M.T., Cirrito, T.P., Kaplan, A.D. and Kaplan,H.J.: Experimental autoimmune anterior uveitis ( EAAU ). 1995. Induction with melanin associated antigen from the iris and ciliary body. Invest Ophthalmol Vis Sci. 36: 1056-1066. Bora, N. S. , Gobleman, C. L. , Atkinson, J. P. , Pepose, J. S. and kaplan, H. J. 1993. Differential expression of the complement regulatory proteins in the human eye. Invest Ophthamol Vis Sci. 34 : 3579-3584. Bora, N.S., Post, T.W. and Atkinson, J.P.: Membrane cofactor protein (MCP) of the complement system. 1991. A Hind III restriction fragment length polymorphism (RFLP) that correlates with the expression polymorphism. J. Immunol. 146:2821-2825. Bora, N.S., Lublin, D.M., Kumar, B.V., Hockett, R.D., Holers, V.M. and Atkinson, J.P. 1989. Structural gene for MCP maps to within 100 kb of the 3' end of the C3b/C4b receptor (CR1) gene. J. Exp. Med. 169:597-602.
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