Sankaranarayanan Kaliappan, M.D.

Education:

• Thanjavur Medical College , Thanjavur, India
  M.D.
• Post-doctoral Training, University of Louisville, Louisville, KY

Academic Appointments:

Instructor, Department of Ophthalmology

Research Interests:

My research interests include studies of diabetic retinopathy and age-related macular degeneration (AMD).  AMD is the leading cause of irreversible blindness and vision impairment in people over age 50 in the United States and the western world. Currently, there is no cure for AMD, and treatments are very limited. Finding the cause of wet AMD is our challenge, and research is the only hope for the future. We areusingrodent model of laser-induced choroidal neo-vascularization (CNV) to study the etiopathogenesis as well as finding a cure for CNV in wet AMD. We are also using rodent models of diabetic retinopathy to find the causes and treatment of this blinding disease.

Peer-Reviewed Manuscripts:

Bora, P.S., Sohn, J.H., Cruz J.M.C., Jha, P, Nishihori, H., Wang, Y., Kaliappan, S., Kaplan, H.J. and Bora, N.S. Role of Complement and Complement  Membrane Attack Complex in Laser-Induced Choroidal Neo-Vascularization. J. Immunol., Jan 2005; 174: 491 - 497.

Bora, P S, Kaliappan, S, Xu, Q, Kumar,S, Wang, Y., Kaplan, H.J. and Bora, N.S. Alcohol Linked to enhanced angiogenesis in Rat model of choroidal-neovascularization. FEBS, 273(2006) 1403-1414.

Bora, N.S., Kaliappan, S., Jha, P., Qin, X. Sohn, J. H., Dhaulakhandi, D.B., Kaplan H.J. and Bora, P.S. Complement Activation via Alternative Pathway is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H.  J of Immunology, 177: 1872-1878, 2006.

Bora, N.S., Kaliappan, S., Jha, P., Xu, Q., Sivasankar, B., Harris, C.L., Morgan, B.P. and Bora, P.S. CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in Wet-type Age-related Macular Degeneration. Journal of  Immunology, 2006 (In Press).