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IBS
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Clinical and
Translational Sciences Faculty
Track Leader-William D.
Wessinger, Ph.D.
Sameh R. Abul-Ezz, M.D., Ph.D. (Nephrology)
Web profile
My current research interests include early kidney transplant function and the development of urinary biomarkers for early detection of acute kidney failure and acute rejection.
Abulezzsamehr@uams.edu
Cornelia Beck, Ph.D. (Geriatrics)
Web profile
Our research
focuses on delaying functional decline and dealing with behavioral symptoms
in persons with Alzheimer's disease. Our interventions involve capitalizing
on the person's remaining strengths and individualizing behavioral and
psychosocial approaches.
BeckCornelia@uams.edu
Warren Bickel, Ph.D. (Psychiatry)
Web profile
Neurobehavioral mechanisms of addiction and
therapeutic processes underlying recovery from addiction.
Sarah Blossom, Ph.D. (Pediatrics)
Web profile
Blossom is an immunologist working in the area of immunotoxicology and reproductive immunology. Her research uses a mouse model to study the neuroimmune modulation caused by maternal and early life exposure to toxicants such as trichloroethylene and cigarette smoke. Understanding the immunologic basis and environmental triggers involved in the etiology of neurologic disorders could be crucial for the development of effective screening, therapeutic, and preventive strategies for human disorders. Dr. Blossom also conducts research within the Section of Birth Defects Research by studying the role of the maternal immune response and congenital heart defects in humans.
BlossomSarah@uams.edu
Puran Bora, Ph.D. (Opthalmology)
Web profile
Age Related Macular Degeneration (AMD), an eye disease which can cause loss of central vision in the population over the age of 50. Our laboratory is studying the Molecular and Biochemical mechanisms of AMD and uvietis
in order to find a cure and/or prevention of the diseases.
pbora@uams.edu
Alan Budney, Ph.D. (Interdisciplinary Biomedical Sciences)
Web profile
ajbudney@uams.edu
Elizabeth Ann Coleman, Ph.D., R.N. (Nursing Sciences)
Web profile Symptom management and supportive care, familial risk of cancer
colemanann@uams.edu
Mario Cleves, Ph.D. (Pediatrics)
Web profile
Current research interests focus on discerning the genetic and environmental causes of major structural congenital malformations, particularly neural tube and congenital heart defects, and the assessment of qualify of pediatric health services and interventions to modify health care provider behavior.
ClevesMarioA@uams.edu
Sharon Coon, Ph.D., R.N. (Nursing Sciences)
Web profile
Cancer symptom management, exercise for patients with cancer, identifying and
improving patients' experiences during the cancer experience.
coonsharonk@uams.edu
Marsha Eigenbrodt, M.D., M.P.H. (Cardiology) Web profile
As a pathologist and epidemiologist, I have broad interests in chronic diseases with a particular interest in the methodological issues facing observational and clinical studies. Specific interests include indicators of arteriosclerosis severity and vascular aging, gene-environmental interactions, orthostatic hypotension, stroke, the relationship between alcohol and cardiovascular disease, and novel vascular risk factors in renal disease.
eigenbrodtmarshal@uams.edu
W. Brooks Gentry, M.D. (Anesthesiology, Pharmacology and
Toxicology) Web profile
Our goal is to develop
antibody-based medications for stimulant abuse, which alter the
pharmacokinetic properties of these drugs. These studies are part of a
multidisciplinary, clinician scientist approach to the rational development
of therapeutic strategies, and provide the background information necessary
for translational research of the efficacy of antibody-based medications for
the treatment of human drug abuse.
gentrywilliamb@uams.edu
Martin Hauer-Jensen, M.D., Ph.D. (Interdisciplinary Biomedical
Sciences) Web profile Radiation biology; gastrointestinal pathophysiology; endothelial biology
Hauerjensenmartin@uams.edu
Howard Hendrickson, Ph.D. (Pharmaceutical Sciences) Web profile
hendricksonhowardp@uams.edu
Jack Hinson, Ph.D. (Pharmacology and Toxicology)
Web profile
jahinson@uams.edu
Charlotte Hobbs, M.D., Ph.D. (Pediatrics, Epidemiology)
Web profile
Our team's research interests include genetic epidemiology, congenital heart defects, genomics, oxidative stress, folate-related pathways, diabetes, obesity, and prematurity.
HobbsCharlotte@uams.edu
Laura James, M.D. (Interdisciplinary
Toxicology) Web profile
Dr. Laura James is Principal
Investigator for the Pediatric Pharmacology Research Unit at Arkansas
Children's Hospital. Her research emphasis in the basic sciences is in understanding
mechanisms of repair for hepatotoxins (acetaminophen, chloroform) in the
mouse model. She is also interested in the detection of biomarkers of
acetaminophen toxicity (acetaminophen protein adducts) in clinical samples
and their correlation with clinical endpoints.
JamesLauraP@uams.eduLouanne Lawson, Ph.D., R.N.,
FAAN, DF-IAFN (Nursing
Science)
Web profile
Child abuse prevention
lawsonlouanne@uams.edu
Kim E. Light, Ph.D. (Pharmaceutical
Sciences)
Web profile
My research
program is aimed at developing neuronal systems and the alterations to
development that result subsequent to exposures to alcohol and other drugs. Our
current approach involves immunofluorescence labeling of specific cellular
structures, at various developmental times, followed by confocal microscopy
analysis of structural neuronal features characteristic of normal developmental
as well as specific drug-induced alterations.
LightKimE@uams.edu
Curtis Lowery M.D. (Obstetrics
and Gynecology)
Web profile Dr. Lowery leads the Fetal Instrumentation Group (FIG), a collaborative effort between UAMS and UALR to develop newer more accurate methods of maternal-fetal assessment. Through an active research program the FIG has designed and developed several novel instruments and conducted clinical studies on the fetus. His efforts to develop a completely non-invasive maternal-fetal physiograph resulted in NIH funding to construct the first fetal MEG system called SARA (SQUID Array for Reproductive Assessment). Dr. Lowery has created three model telemedicine programs. The Antenatal & Neonatal Guidelines, Education and Learning System (ANGELS) is a high-risk pregnancy consultation service delivering never-before-available care in rural Arkansas. The Center for Distance Health offers rural Arkansas access to all medical specialties through telemedicine. Arkansas Telehealth Oversight and Management (ATOM) is a statewide consortium of healthcare providers aimed at improving service delivery in rural Arkansas through telemedicine. Finally, Dr. Lowery is the PI of a major NIH Clinical and Translational Science Award (CTSA) to the UAMS campus.
LoweryCurtisL@uams.edu
Stewart MacLeod, Ph.D. (Pediatrics)
Web profile
Molecular and cell biology
MacLeodStewartL@uams.edu
Lee Ann MacMillan-Crow, Ph.D. (Pharmacology and Toxicology)
Web profile
Our laboratory has been investigating the role that increased mitochondrial oxidant production has on the early events leading to renal dysfunction following renal preservation and warm ischemia/reperfusion (I/R) in vivo. Previous studies have suggested that inactivation of the major antioxidant within the mitochondria, manganese superoxide dismutase (MnSOD), plays a pivotal role in inducing renal injury during I/R injury. Using both cell and rodent models we are also assessing the therapeutic potential of known and novel antioxidants to alter I/R and transplantation induced renal dysfunction.
macmillancrowleea@uams.edu
Stavros Manolagas, M.D., Ph.D. (Internal Medicine)
Web profile
Basic research into the interplay among hormones, cytokines, the hematopoietic/immune system and bone.
ManolagasStavros@uams.edu
Bradley C. Martin, Pharm.D., Ph.D. (Pharmacy Practice) Web profile
The
Pharmaceutical Evaluation and Policy program investigates the impact
pharmaceutical products, policies, and services has on patient and system
level outcomes.
bmartin@uams.edu
Glen P. Mays, Ph.D. (Health Systems Research)
Health and
economic impact of health insurance designs and public health policies, quality
and cost-effectiveness of public health services, econometric methods for the
evaluation of health care systems.
GPMays@uams.edu
Robert E. McGehee, Ph.D. (Pathology,
Physiology & Biophysics, Bioinformatics)
Web profile Molecular biology; adipocyte development; regulation of adipogenesis by retinoblastoma proteins
rem@uams.edu
Jean McSweeney, Ph.D. (Nursing
Science)
Web profile
Women and cardiovascular disease, focusing on early warning and acute symptoms
of myocardial infarction
mcsweenyjeanc@uams.edu
Donald Mock, M.D., Ph.D. (Clinical Nutrition, Biochemistry and
Molecular Biology) Web profile
AREAS OF CURRENT RESEARCH INTEREST
1. Nutrition of Biotin- Incidence of biotin deficiency in pregnancy and potential role of biotin deficiency in human teratogenesis; biotin metabolism, particularly degradation and regulation of degradation of biotin; mechanism and regulation of cellular uptake including inborn errors of biotin transport; role of biotin in biotinylation of histones and their potential role on DNA replication or transcription.
2. Non-radioactive measurement of red cell mass and red cell survival.
3. Biotinylation of low molecular peptides hormones such as erythropoietin and subsequent quantitation in order to study pharmacokinetics of endogenously secreted erythropoietin and potentially other hormones
mockdonaldm@uams.edu
Jeffery Moran, Ph.D. (Pharmacology and Toxicology) My research
efforts focus on developing new metabolomic approaches which can help us better
understand adverse drug reactions and provide new therapeutic strategies.
Currently, we are studying phase I and II metabolism of warfarin and applying
this information to clinical applications by trying to understand the
relationship between warfarin metabolism and anticoagulant therapy outcomes.
Jeff.Moran@arkansas.gov
Mayumi Nakagawa, M.D., Ph.D. (Pathology)
Web profile
T cell immunity to human papillomavirus as it relates to the development of
therapeutic vaccines and immunotherapy.
mnakagawa@UAMS.EDU
Alison Oliveto, Ph.D. (Psychiatry and Behavioral Sciences)
Web profile
Research interests include the phase I and II clinical trials focused primarily on the development of new medications and combinations of medication and behavioral interventions for the treatment of opioid and/or psychostimulant dependence and withdrawal.
olivetoalison@uams.edu
S. Michael Owens, Ph.D. (Pharmacology,
Interdisciplinary Toxicology)
Web profile
owenssamuelm@uams.edu
Carmen T. Paniagua, Ed.D., RN,
MSN, APN, ACNP-BC (Nursing Science)
Web profile Research interest in the translation of genetics/genomics into clinical practice and cancer genetics. Current research is on the identification of genes for the susceptibility of alcohol/nicotine dependence in the Hispanic population.
PaniaguaCarmen@uams.edu Anna Radominska-Pandya, Ph.D. (Biochemistry and Molecular Biology)
Web profile Structure-function relationship studies of human UDP-glucuronosyltransferases (UGTs); Transcriptional regulation of UGTs via environmental pollutants; Role of UGTs in breast cancer and in cancer prevention; and Detoxification of drugs and endogenous compounds
RadominskaAnna@uams.edu
Nancy J. Rusch, Ph.D. (Pharmacology, Interdisciplinary Toxicology)
Web profile
NRusch@uams.edu
Robert Safirstein, M.D. (Physiology and Biophysics,
Bioinformatics)
Web profile My research interests are Acute Kidney Injury, cell signaling and cell cycle control.
SafirsteinRobertL@uams.edu
Gal Shafirstein, Ph.D. (Otolaryngology)
Web profile
Developing surgical medical devices and modalities for treatment of cancer and
benign lesions
Mathematical modeling of thermal ablation
ShafirsteinGal@uams.edu
Catherine Stanger, Ph.D. (Interdisciplinary Biomedical Sciences)
Web profile
Dr. Stanger's interests include adolescent
substance abuse, parenting interventions, and substance abusing families.
Her most recent NIDA-funded projects include developing and testing a
behavioral family intervention for adolescent marijuana abuse and developing
and testing a parenting intervention for substance abusing parents.
cstanger@uams.edu
Katherine E. Stewart, Ph.D., M.P.H. (Health Behavior and Health
Education, COPH)
Behavioral science approaches to reducing sexual health risk; improving outcomes in
HIV-positive patients and persons with other chronic illnesses, and addressing
racial health disparities in sexual and reproductive health.
kestewart@uams.edu
Sundararaman Swaminathan,M.D. (Nephrology)
Web profile
My research laboratory's focus is on understanding mechanisms of nephrogenic systemic fibrosis with a special emphasis on the role of iron, T-helper pathways and macrophages. Additional areas that we are currently evaluating include the role of circulating mesenchymal cells in vascular calcification and calciphylaxis. My clinical research interest involves understanding pathogenic mechanisms of polyoma nephropathy in renal transplant.
SSwaminathan@uams.edu
Galen Wenger Ph.D. (Pharmacology & Toxicology)
Web profile
My research interests are in the measurement of cognitive function in laboratory
animals, the effects of drugs of abuse on cognitive function, and the effect of
cognitive enhancers in a mouse model of Down syndrome.
grwenger@uams.edu
William D. Wessinger, Ph.D. (Pharmacology, Interdisciplinary
Toxicology) Web profile
My research interests are in the behavioral pharmacology
of drug abuse and the mechanisms of drug dependence and addiction. We are
currently conducting research to test antibody-based medications designed to
stop or prevent methamphetamine self-administration and/or relapse to
methamphetamine use.
wdwessinger@uams.edu
Delia West, Ph.D. (Health Behavior & Health Education)
Obesity treatment and prevention, particularly treatment outcome studies
which often target populations with obesity-related comorbidities such as
type 2 diabetes. Research conducted in community-based settings or
population-based recruitment.
WestDelia@uams.edu
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