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Department of Internal Medicine
Faculty Publications 2004-2008

Division of Hematology Oncology

Alikhan MA, Carter G, Mehta P. Topical GM-CSF hastens healing of leg ulcers in sickle cell disease. Am J Hematol 2004 Jun;76(2):192.

Alikhan MA, Kaushal V, Mehta P, Spencer HJ, Kohli M. Prognostic value of plasma vascular endothelial growth factor in hormone-sensitive advanced stage prostate cancer: An exploratory analysis. Proc of ASCO 23:4683, 2004. Abstract.

Ambrosone CB, Barlow W, Yeh I-T, Hayes DF, Davis W, Rae JM, Hutchins LF, Livingston R, Ravdin P, Martino S, Osborne K, Abeloff M, Lyss AP, Albain K. (SWOG) Pharmacogenetics and breast cancer treatment outcomes: results on oxidative stress-related genotypes (MPO, MnSOD) from a southwest oncology group intergroup trial (INT-01012).  29th Annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment. 2006 December 14-17; 100:37. Abstract.

Carter G, Mehta P. Decreased erythropoietin usage in a VA center using a model outreach program. Proc of ASH, 2005. Abstract.

Coleman EA, Hutchins L, Goodwin J. An overview of cancer in the older adult. Medsurg Nurs 2004 Apr;13(2):75-80, 109; quiz 81.

Eid AA, Hennings L, Caradine K, Hodges A, Safar AM. Immature vessel percentage (IVP) as a potential predictive factor for anti-angiogenic therapeutics. Proc of ASCO 25(18S):21137, 2007. Abstract.

Eid A, Petty M, Hutchins L, Thompson AR. Breaking Bad News Standardized Patient Intervention (BBSPI) Improves Hematology-Oncology Fellows’ and Advanced Practice Nurses: Skills in Breaking Bad News. J Cancer Education 22(4)Supp:60, 2007. Abstract.

Ganz PA, Hussey MA, Moinpour CM, Unger JM, Hutchins LF, Dakhil SR, Giguere JK, Goodwin JW, Martino S, Albain KS. Late cardiac effects of adjuvant chemotherapy in breast cancer survivors treated on Southwest Oncology Group protocol s8897.J Clin Oncol. 2008 Mar 10;26(8):1223-30. Epub 2008 Jan 28.

Gentry RW, Mehta J, Safar M, Kyasa MJ, Thompson R, Hester DM, Mehta P. Disclosing prognosis when patients don’t ask. Fed Pract 2006;23(4):14-16, 33.

Gentry R, Mehta J, Hester M, Thompson R, Mehta P. When is the best time to refer to hospice? Federal Practitioner 2007; 11: 51-53.

Gentry RW, Govindarajan R, Spencer HJ. The impact of lymph node dissection in patients with colorectal cancer. Proc of ASCO 25(18S):17055, 2007. Abstract.

Gonzalez R, Hutchins L, Nemunaitis J, Atkins M, Schwarzenberger PO. Phase 2 trial of Allovectin-7 in advanced metastatic melanoma. Melanoma Res 2006;16(6):521-6.

Govindarajan R, Ratnasinghe L, Midathada M, Kim P, Darbe M, Barnhart S, Siegel E, Simmons D, Kim L, Lang N. Association between the use of thiazolidinediones and the risk of cancer in diabetic patients. Proc of ASCO 23(16S):1005, 2005.Abstract.

Govindarajan R, Parthasarathy S. Glycodelin: A possible new biological marker in colorectal cancer. Proc of ASCO 24(18S):20081, 2006.Abstract.

Govindarajan R, Adusumilli J, Baxter DL, El-Khoueiry A, Harik SI. Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006. J Clin Oncol  2006; 24(28):e48.

Govindarajan R, Siegel ER, Simmons DL, Lang NP. Thiazolidinedione (TZD) exposure and risk of squamous cell carcinoma of head and neck (SCCHN). Proc of ASCO 25(18S):1511, 2007. Abstract.

Govindarajan R, Ratnasinghe L, Simmons DL, Siegel ER, Midathada MV, Kim L, Kim PJ, Owens RJ, Lang NP. Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J Clin Oncol 2007; 25(12):1476-81.

Govindarajan R, Young JW, Harless CL, Hutchins, LF. Barriers to clinical trials vary according to the type of trial and the institution. J Clin Oncol 2007; 25 (12):1633-4; 1634.

Greene GF, Gokden N, Hutchins LF, Williams RC. Metastatic renal cell carcinoma to prostate. Urology 2005 Jun;65(6):1227.

Hanna E, Alexiou M, Morgan J, Badley J, Maddox AM, Penagaricano J, Fan CY, Breau R, Suen J. Intensive chemoradiotherapy as a primary treatment for organ preservation in patients with advanced cancer of the head and neck: efficacy, toxic effects, and limitations. Arch Otolaryngol Head Neck Surg 2004 Jul;130(7):861-7.

Hennings L, Artaud C, Jousheghany F, Monzavi-Karbassi B, Hutchins L, Kieber-Emmons T. Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer. 29th Annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment. 2006 December 14-17; 100:1125. Abstract.

Hershman D, Unger J, Barlow W, Hutchins L, Martino S, Abeloff M, Norton L, Livingston R, Osborne K, Albain K. Treatment quality and outcome of African American vs. European American breast cancer patients: retrospective analysis of southwest oncology group studies S8814/S8897.  29th Annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment. 2006 December 14-17; 100:3049. Abstract.

Hutchins L, Moon J, Clark J, Thompson J, Yost K, Sondak V. Interferon alpha-2b and thalidomide in previously treated patients with disseminated malignant melanoma: SWOG 0026. Proc of ASCO 23:7527, 2004. Abstract.

Hutchins LF, Green SJ, Ravdin PM, Lew D, Martino S, Abeloff M, Lyss AP, Allred C, Rivkin SE, Osborne CK. Randomized, controlled trial of cyclophosphamide, methotrexate, and fluorouracil versus cyclophosphamide, doxorubicin, and fluorouracil with and without tamoxifen for high-risk, node-negative breast cancer: treatment results of Intergroup Protocol INT-0102. J Clin Oncol 2005 Nov 20;23(33):8313-21.

Hutchins LF, Moon J, Clark JI, Thompson JA, Lange MK, Flaherty LE, Sondak VK. Evaluation of interferon alpha-2B and thalidomide in patients with disseminated malignant melanoma, phase 2, SWOG 0026.Cancer. 2007 Nov 15;110(10):2269-75.

Joseph J, Rimawi A, Mehta P, Cottler-Fox M, Sinha A, Singh BK, Pacheco R, Smith ES 3rd, Mehta JL. Safety and effectiveness of granulocyte-colony stimulating factor in mobilizing stem cells and improving cytokine profile in advanced chronic heart failure. Am J Cardiol 2006 Mar 1;97(5):681-4. Epub 2006 Jan 6.

Kapoor P, Singh E, Radhakrishnan P, Mehta P. Splenectomy in plasma cell dyscrasias: a review of clinical practice. Am J Hematol 2006; 81: 945-54.

Karri S, Carter G, Safar A, Kyasa MJ, Mehta P. Managing Erythropoeitin usage in a large Veterans healthcare System. Proc of ASH. Blood Supplement Nov 16,2005; 106(11):2258. Abstract.

Karri S, Doshi V. Hematological abnormalities in copper deficiency. Blood 110(11): 2677, 2007.Abstract.

Karri S, Govindarajan R, Bendure WB. Screening and genetic counseling practices for hereditary non-polyposis colorectal cancer (HNPCC). Proc of ASCO 25(18S):6564, 2007. Abstract.

Khalil O, Govindarajan R, Safar M, Hutchins L, Mehta P. Clinical trial registration and the ICMJE. JAMA 2005 Jan 12;293(2):157; author reply 158.

Kaushal V, Kaushal GP, Mehta P. Differential toxicity of anthracyclines on cultured endothelial cells. Endothelium 2004 Sep-Dec;11(5-6):253-8.

Kaushal V,  Mehta P, Gokden N, Kohli M, Dennis R A , Fink LM.  ETS-1 and tissue factor expression and regulation in PC-3 cells in vitro and in prostate cancer in vivo.  Proc of AACR, Mar 2005:4630. Abstract. 

Kaushal V, Mehta P, Fink L. Tissue Factor and Factor VIIa Regulate Expression of Ets-1 in Prostate Cancer, International Society for Thrombosis and Haemostasis, Sydney, Australia. August 2005. Abstract.

Keshava-Prasad H, Kaushal V, Mehta P.  Effects of thalidomide on platelets in vivo and in vitro. Blood 2006; 108:3969. Abstract.

Khalid AA, Morgan JE, Horace S, Hanna EY, Breau R, Kyasa MJ, Maddox AM. Early complications of organ preservation treatment in head and neck cancer, UAMS experience. Proc of ASCO 23:5607, 2004. Abstract.

Kohli M, Zent C, Hutchins LF, Safar M, Dotson P, Mehta P. The academic hematology-oncology firm:a model for postgraduate cancer education. J Cancer Educ. 2004 Spring;19(1):45-9.

Kota M, Shah R, James J, Kohli M, Greene G, Maddox AM. Cyclooxygenase-2 expression in renal cell neoplasms. Proc of ASCO 23:9699, 2004. Abstract.

Kyasa MJ. Phase II trial of Tamoxifen and interferon alpha in patients with metastatic or recurrent soft tissue sarcoma. Proc of ASCO 23:9031, 2004. Abstract.

Linden HM, Haskell CM, Green SJ, Osborne CK, Sledge GW Jr, Shapiro CL, Ingle JN, Lew D, Hutchins LF, Livingston RB, Martino S. Sequenced compared with simultaneous anthracycline and cyclophosphamide in high-risk stage I and II breast cancer: final analysis from INT-0137 (S9313). J Clin Oncol 2007; 25(6):656-61. 

Ma Q, Safar M, Holmes E, Wang Y, Boynton AL, Junghans RP. Anti-prostate specific membrane antigen designer T cells for prostate cancer therapy.  Prostate Sept 15, 2004;61(1):12-25.

Makhoul I, Esllinger P, Popescu D, Harvey H, Parkinson K, Lipton A. Effect of aromatase inhibitor therapy on cognitive function. Proc of ASCO 23:846, 2004. Abstract.

Makhoul I, Curti B and Sachdeva K. Extragonadal germ cell tumors. eMedicine, eMedicine Specialties: Medicine, OB/gyn, Psychiatry, and Surgery: Hematology [Internet].June 30, 2004. Available from  http://www.emedicine.com/med/topic759.htm.

Makhoul I, Claxton D, Rybka W. Pure B-Cell Disorders. eMedicine, eMedicine Specialties: Medicine, OB/Gyn, Psychiatry, and Surgery: Hematology [Internet]. Aug 25, 2006. Available from: http://www.emedicine.com/med/topic216.htm

Makhoul I, Harvey H, Makhoul H, Souba W. Breast cancer. eMedicine,  eMedicine Specialties: Medicine, OB/Gyn, Psychiatry, and Surgery: Oncology [Internet].Sep20, 2006. http://www.emedicine.com/med/topic2808.htm

Makhoul I, Javeed M, Ballard J. Spur Cell Anemia. eMedicine, eMedicine Specialites: Medicine, OB/Gyn, Psychiatry, and Surgery: Hematology [Internet]. Aug 25, 2006. Available from: http://www.emedicine.com/med/topic2163.htm.

Mamounas E, Jeong J-H, Wickerham L, Smith R, Geyer C, Ganz P, Land S, Hutchins L, Eisen A, Ingle J, Costantino J, Wolmark N. Benefit from exemestane (EXE) as extended adjuvant therapy after 5 years of tamoxifen (TAM): intent-to-treat analysis of NSABP B-33.  29th Annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment. 2006 December 14-17; 100:49. Abstract.

Mamounas EP, Jeong JH, Wickerham DL, Smith RE, Ganz PA, Land SR, Eisen A, Fehrenbacher L, Farrar WB, Atkins JN, Pajon ER, Vogel VG, Kroener JF, Hutchins LF, Robidoux A, Hoehn JL, Ingle JN, Geyer CE Jr, Costantino JP, Wolmark N. Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trial.J Clin Oncol. 2008 Apr 20;26(12):1965-71. Epub 2008 Mar 10.

Mansoor M, Ryan CJ, Makhoul I, Sachdeva K, Curti B. Germ Cell Tumors. eMedicine, eMedicine Specialties: Medicine, OB/Gyn, Psychiatry, and Surgery: Oncology[Internet]. July 27, 2006. http://www.emedicine.com/med/topic863.htm

Margulies AG, Makhoul I, Henry-Tillman R, Kepple J, Adkins L, Colvert M, Korourian S, Klimberg VS. Tumor Burden in Neoadjuvant Sentinel Lymph Node Biopsy May Predict Response to Chemotherapy. Am Surgical Assoc Meeting 2005. Abstract.

McLaughlin P, Estey E, Glassman A, Romaguera J, Samaniego F, Ayala A, Hayes K, Maddox AM, Preti HA, Hagemeister FB. Myelodysplasia and acute myeloid leukemia following therapy for indolent lymphoma with fludarabine, mitoxantrone, and dexamethasone (FND) plus rituximab and interferon alpha. Blood 2005 Jun 15;105(12):4573-5. Epub 2005 Mar 1.

Mehta P, Kaushal V. Effect of daclizumab for graft-versus-host disease after bone marrow transplantation on lymphocyte-endothelial cell interaction. Intl Soc Thromb and Haem. Sydney, Australia, August 2005. Abstract.

Mehta P. Poems on Cancer Education. J Cancer Educ 2006; 21(2):108-9.

Mehta P. Chemotherapy induced neutropenia in the new millennium. Federal Practitioner 2006; 23 (supplement 2) 2-3. 

Mehta P. He didn't have a chance. J Clin Oncol 2007 Aug 1;25(22):3378-9.

Mehta P. Special Treatment: A commentary on "When Two Worlds Collide." J Clin Oncology 2007; 25: 4018-9.

Mehta P, Hester M, Safar AM, Thompson R. Ethics-in-oncology forums. J Cancer Educ 2007 Fall;22(3):159-64.

Mehta P, Nair B. TNF alpha inhibition and AML. Am J Hematol 2007 Dec 27; [Epub ahead of print]

Midathada MV, Mehta P, Waner M, Fink LM. Recombinant factor VIIa in the treatment of bleeding. Am J Clin Pathol 2004 Jan;121(1):124-37.

Midathada MV, Spencer T, Mack K, Erkman L, Govindarajan R. Influence of demographics on patient refusal to enroll into clinical trials. Proc of ASCO 23(16S):6038, 2005. Abstract.

Midathada M, Mehta J, Govindarajan R, Safar AM, Hester DM, Kyasa MJ, Mehta P. When substance abuse interferes with cancer treatment. Federal Practitioner 2006; 23 (9): 39-51. 

Monzavi-Karbassi B, Hennings LJ, Artaud C, Liu T, Jousheghany F, Pashov A, Murali R, Hutchins LF, Kieber-Emmons T. Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer and melanoma. Vaccine 2007; 25(16):3022-31. 

Nair BP and Safar AM. Utilization of positron emission tomography scans (PET) in the management of NSCLC at a center with limited access to this imaging modality. Proc of ASCO 24(18S):6140, 2006. Abstract.

Nair  B, Spencer T, Rival G, Mehta P.  Correlation of content of hemoglobin in reticulocytes (CHR) in hematologic disease. Blood 2006; 108: 5526. Abstract.

Nair B, Mehta P. Pilot program of smoking cessation in patients with smoking-related cancers. Accepted for poster presentation, American Association of Cancer Education annual meeting, San Diego, CA, October 2006.  J Cancer Education 2006; 21 (suppl 2):40. Abstract.

Nair B, Mehta P. Reviews of “Bone Marrow and Stem Cell Transplantation” and “Renewing the Stuff of Life: Stem Cells, Ethics and Public Policy,” JAMA 2007; 298: 1571.

Nair B, Raval G, Mehta P. TNF-alpha inhibitor etanercept and hematologic malignancies: report of a case and review of the literature. Am J Hematol 2007 Nov;82(11):1022-4.

Nair BP, Khalil O, Phooshkooru VR, Hutchins LF. Weight change among breast cancer patients receiving chemotherapy: A retrospective analysis. Proc of ASCO 25(18S): 19535, 2007.Abstract.

Nagarajan A, Mehta J, Safar M, Thompson R, Mehta P. Whent eh patient, family, and physicians disagree about treatment. Fed Pract 2005;22(1):15-16, 18.

Norris LB and Mehta P.  The role of granulocyte growth factors. Federal Practitioner 2006; 23 (supplement 2) 16-25. 

O’Day S, Gonzalez R, Lawson D, Weber R, Hutchins L, Anderson C, McLeod M, Hurwitz C, Haddad J, Jacobson E. Subgroup analysis of efficacy and safety analysis of a randomized, double-blinded controlled phase II study of STA-4783 in combination with paclitaxel in patients with metastatic melanoma. Proc of ASCO 25(18S):8528, 2007. Abstract.

Piekarz R, Frye R, Wright J, Figg W, Allen S, Kirschbaum M, Zain J, Hutchins L, Showe L, Fojo T, Bates SE. Update of the NCI multiinstitutional phase II trial of romidepsin, FK228, for patients with cutaneous or peripheral T-cell lymphoma. Proc of ASCO 25(18S):8027, 2007. Abstract.

Pierce LJ, Hutchins LF, Green SR, Lew DL, Gralow JR, Livingston RB, Osborne CK, Albain KS. Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancer. J Clin Oncol 2005 Jan 1;23(1):24-9. Epub 2004 Nov 15.

Prasad HK, Govindarajan R. Heparin-induced skin necrosis associated with thrombocytopenia and acquired protein C and protein S deficiency. Am J Hematol 2007 Dec;82(12):1116-7.  

Prasad HK, Kaushal V, Mehta P. Isolated thrombocytopenia induced by thalidomide in a patient with multiple myeloma: case report and review of literature. Am J Hematol 2007 Sep;82(9):855-7.

Raval GG, Wingard JR, Mehta P. Bone Marrow Transplantation, Long-Term Effects. eMedicine, eMedicine Specialties: Pediatric: Oncology [Internet]. July 31, 2006.  http://www.emedicine.com/ped/topic2551.htm.  

Safar AM and Shwaiki A. The impact of platelet count (Pit#) on outcome in curable non-small cell lung cancer (NSCLC). Proc of ASCO 23:9734, 2004. Abstract.

Safar AM, Spencer H 3rd, Su X, Coffey M, Cooney CA, Ratnasinghe LD, Hutchins LF, Fan CY. Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res 2005 Jun 15;11(12):4400-5.

Safar AM, Al-Khasawneh K, Su X, White P, Fan C. Sputum methylation has low specificity as diagnostic test for lung malignancy. Proc. ASCO 9633, 2005. Abstract. 

Safar AM, Kyasa MJ, Thompson R, Hester M, Mehta P. Impact of ethics-in-oncology forums in a Hematology Oncology Fellowship Program. Am Assoc Cancer Educ, 2005. Abstract.

Safar AM, Spencer HJ, III, Su X, Hutchins LF, Chun-Yang F. DNA methylation in lymph nodes of stage I NSCLC: common finding devoid of prognostic impact.  Proc. AACR 2769, 2005. Abstract.

Safar AM, Macleod S, Klimberg V, Henry-Tillman R, Fan C, Hutchins L, Makhoul I. Hydralazine-demethylating systemic therapy for breast cancer. Proc of ASCO 24(18S): 13131, 2006.Abstract.

Safar AM, O'Sullivan P, Ray L, Hutchins L, Mehta P. Editorial clubs as a new teaching tool in postgraduate training. J Cancer Educ 2006; 21(3):163-5.

Safar AM, Spencer H, Su X, Cooney CA, Shwaiki A and Fan C-Y. Promoter hypermethylation for molecular nodal staging in non–small cell lung cancer. Arch Pathol Lab Med 2007; 131(6):936-941. 

Shah RV, Gokden N, James J, Kota M, Kohli M. Expression of epidermal growth factor receptor (EGFR) in renal cell neoplasms. Proc of ASCO 23(16S):9701, 2005. Abstract.

Schichman SA, McClure R, Schaefer RF, Mehta P. HIV and plasmablastic lymphoma manifesting in sinus, testicles, and bones: a further expansion of the disease spectrum. Am J Hematol 2004 Nov;77(3):291-5.

Sherman AC, Edwards D, Simonton S, Mehta P. Caregiver stress and burnout in an oncology unit. Palliat Support Care 2006 Mar;4(1):65-80.

Shwaiki A and Safar AM. The impact of platelet count (Plt#) on outcome in curable colon cancer. Proc of ASCO 23:9735, 2004. Abstract.

Stephenson J, Cohn A, Crawford J, Maddox A-M, Jones S, Lum P, Yang X, Amado R, Burris H. Administration of panitumumab every two weeks (Q2W) as a 30-min or 60-min infusion: Safety and pharmacokinetics (PK) from a phase 1 study in patients with solid tumors. ASCO GI Proceedings 2007; January. Abstract. 

Unger JM, Crowley JJ, Coltman CA, Hutchins LF, Martino S, MacDonald JS, Gandara DS, Crawford ED, Livingston RB, Albain KS. Accrual patterns of the Southwest Oncology Group (SWOG) by sex, race/ethnicity, and age: Updated and expanded analyses. Proc of ASCO 23:6014, 2004. Abstract.

Unger JM, Coltman CA Jr., Drowley JJ, Hutchins LF, Martino S, Livingston RB, Macdonald JS, Blanke CD, Gandara DR, Crawford ED, Albain KS. Impact of the year 2000 Medicare policy change on older patient enrollment to cancer clinical trials. J Clin Oncol 2006 Jan 1;24(1):141-4. Epub 2005 Dec 5.

Wang-Gillam A, Mehta J, Thompson R, Safar M, Mehta P. When it’s time to stop cancer treatment: Helping patients prepare for death. Fed Pract 2005;22(4):14,16,22-23.

Wang-Gillam A, Mehta P. IRB rotations to promote systems competency in hematology/oncology fellowship training programs. J Cancer Education 2006; 21(suppl 2): 24a.

Wang-Gillam A, Miles DA, Hutchins L. Evaluation of vitamin D deficiency in breast cancer patients on bisphosphonate therapy. 29th Annual San Antonio Breast Cancer Symposium. 2006 December 14-17; 100:6098. Abstract.

Wang-Gillam A, Mehta P. Review of “How Doctors Think”, JAMA 2007; 298: 688-689.Wang-Gillam A. Siegel E, Mayes D, Hutchins L, Zhou YH.  Anti-tumor effect of doxycycline on gioblastoma cells.  J Cancer Molecules 2007 November 5;3(5)147-153. 

Wang-Gillam A, Miles DA, Hutchins LF. Evaluation of vitamin D deficiency in breast cancer patients on bisphosphonates.Oncologist. 2008 Jul;13(7):821-7. Epub 2008 Jul 9.

Wong JM, Kyasa MJ, Hutchins L, Collins K. Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita. Hum Genet. 2004 Oct;115(5):448-55. Epub 2004 Sep 3.

 

 

Contact regarding webpage content: GibAnn Berryhill

University of Arkansas for Medical Sciences
College of Medicine

Department of Internal Medicine, Slot 832

4301 W. Markham
Little Rock, AR 72205