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Division of
Endocrinology and Metabolism
Aguirre JI,
Plotkin LI, Vyas K,
Kousteni S, O'Brien CA,
Manolagas SC, Bellido T.
The estrogen receptors (ERa
and ERb)
play an essential role in osteocyte mechanotransduction:
requirement of membrane localization and caveolin-1, but not DNA
binding. J Bone Miner Res 20[suppl 1], 1116. 2005.
Abstract.
Aguirre JI,
Plotkin LI, Vyas K, Stewart
SA, O'Brien CA, Parfitt AM,
Weinstein RS, Manolagas SC, Bellido T.
Osteocyte apoptosis and the loss of bone mineral and strength
induced by tail suspension in mice is entirely caused by reduced
mechanical strains, whereas osteoblast apoptosis is due to
endogenous glucocorticoid actions. J Bone Miner Res
20[suppl 1], 1092. 2005. Abstract.
Ali AA,
O'Brien CA, Gubrij I, Wynne
RA, Parfitt AM, Weinstein RS,
Manolagas SC, Jilka RL.
Evidence that the cellular mechanisms responsible for the
anabolic effect of intermittent PTH are different in murine
cancellous and periosteal bone. J Bone Miner Res 20[suppl
1], M417. 2005. Abstract.
Ali AA,
Weinstein RS, Stewart SA,
Parfitt AM, Manolagas SC,
Jilka RL. Rosiglitazone causes bone loss in mice by
suppressing osteoblast differentiation and bone formation.
Endocrinology 2005;146(3):1226-35.
Almeida M,
Han L, Bellido T, Manolagas SC, Kousteni
S. Wnt proteins prevent apoptosis of both uncommitted
osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent
and -independent signaling cascades involving Src/ERK and
phosphatidylinositol 3-kinase/AKT. J Biol Chem 2005;
280(50):41342-51.
Almeida M,
Han L, Warren A, Lowe V,
Bellido T, Manolagas SC. Wnts suppress
osteoclast survival and formation and prevent apoptosis of
uncommitted osteoblast progenitors and osteoblasts by
b-catenin-dependent as twell as independent signaling
cascades involving Src/ERK and PI3K/Akt. J Bone Miner Res
20[suppl 1], SU 264. 2005. Abstract.
Almeida M, Chen X-D,
Han L, Martin-Millan
M, Lowe V, Warren A, Stewart SA, Kousteni S, Weinstein RS,
O'Brien CA, Bellido T, Jilka RL, Manolagas SC. The liganded
versus unliganded estrogen receptor has opposite effects on
osteoblast differentiation. J Bone Miner Res 2006; 21[Suppl 1],
S95. Abstract.
Almeida M,
Han L, Lowe V, Warren A,
Kousteni S, O'Brien CA, Manolagas SC. Reactive oxygen species
antagonize the skeletal effects of Wnt/b-catenin
in vitro and aging mice by diverting
b-catenin
from TCF- to FOXO-mediated transcription. J Bone Miner Res
2006; 21[Suppl 1], S26. Abstract.
Almeida M,
Han L, Lowe V, Warren A,
Shelton R, Vyas K, Stewart SA, Weinstein RS, Bellido T, O'Brien
CA, Jilka RL, Manolagas SC. Aging or gonadectomy decrease
defense against reactive oxygen species in C57BL/6 mice: a
mechanistic explanation of the exaggeration of the effects of
organismal aging on bone by loss of sex steroids. J Bone
Miner Res 2006; 21[Suppl 1], S8. Abstract.
Almeida M, Han L, Martin-Millan M,
Warren A, Lowe V, Kousteni S, O'Brien CA, Manolagas SC. Wnts
antagonize the effects of 1,25(OH)2D3 and PTH on OPG and RANKL
gene expression by stromal/osteoblastic cells and act directly
on osteoclasts to promote their apoptosis. J Bone Miner Res
2006; 21[Suppl 1], S102. Abstract.
Almeida M, Han L, Weinstein RS,
Jilka RL, Bellido T, O'Brien CA, Kousteni S, Manolagas SC.
Decreased defense against reactive oxygen species: a common pathogenetic mechanism of the effects of aging and estrogen
deficiency on bone. The Endocrine Society's 88th Annual Meeting.
Boston, Massachusetts. 2006 June 24. Abstract.
Almeida M, Chen X-D,
Han L, Martin-Millan
M, Lowe V, Warren A, Scott SA, Kousteni S, Weinstein RS, O'Brien
CA, Bellido T, Jilka RL, Manolagas SC. The Liganded versus
Unliganded Estrogen Receptor Has Opposite Effects on Osteoblast
Differentiation. The Endocrine Society's 89th Annual Meeting.
Toronto, Canada. 2007 June 2-5; P1-629. Abstract.
Almeida M,
Han L, Martin-Millan M,
Lowe V, Warren A, O'Brien CA, Manolagas SC. Oxidative stress
Antagonizes Wnt Signaling in Osteoblast Precursors and Bone of
Aging Mice by Diverting ß-Catenin from TCF- to FOXO-Mediated
Transcription. The Endocrine Society's 89th Annual Meeting.
Toronto, Canada. 2007 June 2-5; P4-79. Abstract.
Banga A, Rasouli N, Kern PA, Owens,
R. Pioglitazone Increases secretion and prevents
dissociation of adiponectin HMW isoform from human fat. The
American Diabetes Association 66th Scientific
Sessions. Washington DC. 2006 June 9-22; 1347-P. Abstract.
Bansal D, Nanda A, Gupta E, Croker
M, Williams M, Bacchus A, Simmons D, Erbland M. Myxedema Coma
in a Patient with Donn’s Syndrome. Ark Med J 2006; 103 (5):
112-3.
Bellido T,
Ali AA, Gubrij I, Plotkin LI, Fu
Q, O'Brien CA, Manolagas SC, Jilka RL.
Chronic elevation of parathyroid hormone in mice reduces
expression of sclerostin by osteocytes: a novel mechanism for
hormonal control of osteoblastogenesis. Endocrinology
2005; 146(11):4577-83.
Bellido T. Downregulation of Sost/Sclerostin
by PTH: A novel mechanism of hormonal control of bone formation
mediated by osteocytes. J Musculoskelet. Neuronal Interact
2006; 6:358-9.
Bellido T. Summary – Osteocyte
control of bone formation via Sost/sclerostin.
J Musculoskelet
Neuronal Interact 2006; 6:360-3.
Bellido T. The osteocyte: The
“third” cell of bone gets to center stage (Report from the 28th
annual meeting of the American Society for Bone and Mineral
Research). BoneKEy-Osteovision 2006; (11) 14-50.
Bellido T, Aguirre JI,
Plotkin L, Vyas K,
O'Brien CA, Manolagas SC. Transduction of mechanical
signals in bone: a novel ligand-independent function of the
estrogen receptor
a and
b.
The Endocrinology Society's 88th Annual Meeting. Boston,
Massachusetts. 2006 June 24. Abstract.
Bi Y, Stuelten
CH, Kilts T, Wadhwa S, Iozzo RV, Robey PG,
Chen XD, Young MF. Extracellular matrix
proteoglycans control the fate of bone marrow stromal cells.
J Biol Chem 2005; 280(34):30481-9.
Bodles A., Varma V., Yao-Borengasser
A., Peterson C., McGehee R.,
Rasouli N., Kern P. Pioglitazone
induces macrophage apoptosis in human adipose tissue. The
American Diabetes Association 66th Scientific
Sessions. Washington DC. 2006 June 9-22. 1880-P. Abstract.
Bodles AM,
Banga A, Rasouli N, Ono F,
Kern PA, Owens RJ. Pioglitazone increases secretion
of high-molecular-weight adiponectin from adipocytes. Am J Physiol Endocrinol Metab 2006; 291(5):E1100-E1105.
Bodles AM,
Varma V, Yao-Borengasser A,
Phanavanh B, Peterson CA, McGehee RE, Jr.,
Rasouli N, Wabitsch M,
Kern PA. Pioglitazone induces
apoptosis of macrophages in human adipose tissue. J Lipid Res
2006;47(9):2080-8.
Bodles AM, Varma V, Yao-Borengasser
A, Phanavanh B, Rashidi AA, McGehee RE, Jr.,
Rasouli N, Kern PA. Pioglitazone Iicreases SUMOylation
in human adipose tissue. The
American Diabetes Association 67th Scientific Sessions. Chicago,
Illinois. 2007 June 22-26; 1403-P. Abstract.
Campeau S, Deng
H, Stefanova R, Paulson DR, Owens RJ,
Loeffeholtz M. Molecular approach tocharacterize
community-associated methicillin-resistant Staphylococcus
aureus clones from Arkansas. Proceedings of the APHL
Invedtious Disease Conference, Emerging infectious diseases -
emerging responses Orlando, Florida. 3-2-2005. Abstract.
Chen JR,
Plotkin LI, Aguirre JI,
Han L, Jilka RL, Kousteni
S, Bellido T, Manolagas SC. Transient
versus sustained phosphorylation and nuclear accumulation of
ERKs underlie anti-versus pro-apoptotic effects of estrogens.
J Biol Chem 2005; 280(6):4632-8.
Chen X,
Manolagas SC,
Jilka RL. Culture of marrow derived mesenchymal
stem cells in 3-dimensional matrices made by marrow stromal
cells promotes retention of the stem cell phenotype. J Bone
Miner Res 20[suppl 1], SA219. 2005. Abstract.
Chen X-D, DeLoose A, Mommsen L,
Dusevich V, Feng J, Manolagas SC, Jilka RL.
The extracellular
matrix produced by bone marrow stromal cells forms a niche for
mesenchymal stem cells. J Bone Miner Res 2006; 21[Suppl 1],
S390. Abstract.
Chen X-D, Stewart SA, Roberson PK,
Wynne RA, Manolagas SC, Jilka RL.
Gene expression patterns in
response to daily injections of PTH to mice: evidence for
priming by the initial dose. J Bone Miner Res 2006; 21[Suppl
1], S322. Abstract.
Choksi P, Thomas R,
Simmons DL. Charcot arthropathy.
An often overlooked complication of diabetes mellitus. J Ark Med
Soc 2007; 103(9):229-31.
Chu WS, Das
SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ,
Jia W, McCarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E,
Elbein SC. Activating
transcription factor 6 (ATF6) sequence polymorphisms in type 2
diabetes and pre-diabetic traits. Diabetes 2007; 56(3):856-62.
Craig RL, Wheeler K,
Elbein S.
Analysis of RBP4 as a candidate gene for Type 2 Diabetes (T2DM).
The American Diabetes Association 66th Scientific
Sessions. Washington DC. 2006 June 9-22; 2360-PO. Abstract.
Craig RL, Chu WS,
Elbein SC. Retinol binding
protein 4 as a candidate gene for type 2 diabetes and
prediabetic intermediate traits. Mol Genet Metab 2007;
90(3):338-44.
Das SK.
Assessing the function of genetic variants involved in Type 2
Diabetes mellitus: In Silico. Molecular and Cellular
Proteomics 2005; June 29;[electronic letter to the Editor].
Das SK. The Indian Genome
Variation database (IGVdb): a project overview. Hum Genet
2005; 118(1):1-11.
Das SK,
Chu WS, Hale TC, Wang X, Craig RL, Wang
H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI,
Zeggini E, Hasstedt SJ, Elbein SC.
Polymorphisms in the glucokinase-associated, dual-specificity
phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak
are associated with type 2 diabetes. Diabetes 2006;
55(9):2631-9.
Das SK, Elbein SC. The Genetic Basis
of Type 2 Diabetes. Cellscience Reviews. 2006; 2:100-131.
Das SK.
Genetic Epidemiology of adult onset Type 2 Diabetes in Asian
Indian Population: Past, Present and Future. Int J Hum Genet
[Special Issue on: Epidemiology of Genetic Diseases in India].
2006; 6(1):1.
Das SK.
Thr394Thr polymorphism (rs2970847) of PPARGC1A gene and obesity
in Asian Indians. Int J Obes (Lond). 2007; 31(3):562-3.
Das SK, Elbein SC. The search for
type 2 diabetes susceptibility loci: the chromosome 1q story. Curr Diab Rep 2007; 7(2):154-64.
Davidson MB, Loachimescu AG,
Makdissi A, et al.
Elevated levels of CD36 expression
on peripheral blood monocytes are associated with glucose
metabolism in healthy subjects with family history of type
diabetes. Diabetes.
2006; 55:A495-A495 Suppl. 1. Abstract.
Di Gregorio GB,
Yao-Borengasser A, Rasouli N,
Varma V, Lu T, Miles LM,
Ranganathan G, Peterson CA, McGehee RE,
Kern PA. Expression of CD68
and macrophage chemoattractant protein-1 genes in human adipose
and muscle tissues: association with cytokine expression,
insulin resistance, and reduction by pioglitazone. Diabetes
2005; 54(8):2305-13.
Deng H, Paulson
DR, Langley S, Campeau S, Owens RJ,
Loeffeholtz M. TaqMan PCR method to identify shiga toxin,
intimin genes and Escherichia coli 0157:H7H7 Serotype.
Proceedings of the 105th ASM General Meeting Atlanta, Georgia.
6-5-2005. Abstract.
Deng H, Paulson
DR, Campeau S, Owens RJ,
Loeffeholtz M. Detection of West Nile Virus RNA in bird eye
swabs. Proceedings of the APHL Invedtious Disease Conference,
Emerging infectious diseases - emerging responses Orlando,
Florida. 3-2-2005. Abstract.
Di GG,
Rasouli
N, Yao-Borengasser A,
Varma V, McGehee RE, Kern PA.
Adipose tissue inflammation and macrophages: Association with
insulin sensitivity and effects of pioglitazone. Proceedings of
the 65th Scientific Session of the American Diabetes Association
San Diego, California, 1433-P. 6-10-2005. Abstract.
Elbein SC,
Craig R, Wang H. Association
of SNPs in tandem genes SCAMP3 and CLK2: Positional and
functional candidates for Type 2 Diabetes. Proceedings of the
65th Scientific Session of the American Diabetes Association San
Diego, California, 1175-P. 6-10-2005. Abstract.
Elbein SC,
Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati
FL, Kao WH. Role of a proline insertion in the insulin promoter
factor 1 (IPF1) gene in African Americans with type 2 diabetes.
Diabetes 2006; 55(10):2909-14.
Elbein SC,
Wang X, Karim MA, Chu WS, Silver KD. Analysis of coding variants
in the betacellulin gene in type 2 diabetes and insulin
secretion in African American subjects. BMC Med Genet 2006;
7:62.
Elbein S,
Chu W, Wang H, Craig R,
Wang X, Hale T. Association of Coding ATF6 Variants with Type 2
Diabetes in Caucasians. The American Diabetes Association 66th
Scientific Sessions. Washington DC. 2006 June 9-22; 1083-P.
Abstract.
Elbein SC, Chu WS,
Das SK, Yao-Borengasser
A, Hasstedt SJ, Wang H, Rasouli N, Kern PA. Transcription Factor
7-Like 2 Polymorphism and Type 2 Diabetes, Glucose Homeostasis
Traits, and Gene Expression in Caucasian and African American
Subjects. The American Diabetes Association 67th Scientific
Sessions. Chicago, Illinois. 2007 June 22-26; 0387-OR. Abstract.
Elbein SC, Chu WS,
Wang H, Das SK,
Gomes T, Sharma N, Kern PA, Rasouli N. Role of Type 2 Diabetes
Susceptibility Variants in Insulin Sensitivity, Insulin
Secretion, and Disposition Index. The American Diabetes
Association 67th Scientific Sessions. Chicago, Illinois. 2007
June 22-26; 1156-P. Abstract.
Fu Q, Wang W,
Olsen BR, Manolagas SC, O'Brien
CA. RUNX2 potentiates, but is not required for, RANKL
expression in mesenchymal cells. J Bone Miner Res
20[suppl 1], M160. 2005. Abstract.
Fu Q, Zella LA, Fretz JA, Cazer PE,
Galli C, Pike JW, Manolagas SC, O'Brien CA. Mice lacking a
distant transcriptional enhancer of the RANKL gene display a
blunted response to PTH and 1,25(OH)2D3 in vitro and in vivo.
J Bone Miner Res 2006; 21[Suppl 1], S53. Abstract.
Fu Q,
Manolagas SC, O'Brien CA. Parathyroid hormone
controls receptor activator of NF-kappaB ligand gene expression
via a distant transcriptional enhancer. Mol Cell Biol 2006;
26(17):6453-68.
Gupta B,
Agrawal C, Raghav SK, Das SK,
Das RH, Chaturvedi VP, Das HR. Association of mannose-binding
lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an
Indian cohort of case-control samples. J Hum Genet 2005;
50(11):583-91.
Govindarajan R, Ratnasinghe LD,
Simmons DL, Siegel ER,
Midathada MS, Kim L, Kim P, Owens RJ,
Lang NP. Thiazolidinediones (TZD) and the risk of lung,
prostate and colon cancer in diabetic subjects. J Clin
Oncol 2007; 25(12):1476-81.
Hakkak R,
Holley A, Ono F, Owens RJ.
Effects of obesity on serum adiponectin levels and breast cancer
dvelopment in lean and obese female zucker rats following DMBA
treatment. Experimental Biology Sand Diego, California.
4-2-2005. Abstract.
Hamid Z, Mrak
R, Ijaz M, Faas F.
Immunohistochemistry of pituitary adenoma: is it helpful? 87th
Annual Endocrine Society Meeting San Diego, CA[Poster Session],
P3-506. 6-7-2005. Abstract.
Hamid Z, Simmons D.
Letter to the
Editor: Triple Therapy in Type 2 Diabetes: Insulin glargine or
rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naïve patients. Diabetes Care 2006; 29:
2331.
Han L, Almeida M,
Chen X-D,
Manolagas SC, Bilezikian JP,
Kousteni S. Hormonal Control of periosteal expansion: estrogens and PTH control the fate of
early periosteal osteoblast progenitors by opposite actions on teh BMP-2 and Wnt signaling cascades. J Bone Miner Res 2006;
21[Suppl 1], S204. Abstract.
Jia D,
O'Brien CA, Parfitt AM,
Manolagas SC, Weinstein RS. Glucocorticoids
act directly on osteolcasts to increase their lifespan and
reduce bone density. J Bone Miner Res 20[suppl 1], F367.
2005. Abstract.
Jia D,
O'Brien CA, Stewart SA,
Manolagas SC, Weinstein RS. Glucocorticoids act
directly on osteoclasts to increase their life span and reduce
bone density. Endocrinology 2006; 147(12):5592-9.
Jilka RL,
Wynne RA, Chen X, Stewart S,
Xu L, Thaden JJ, Weinstein RS,
Manolagas SC. The pathogenesis of age-related bone
loss in mice involves increased production of PPAR
g-activating
oxidized lipids derived from the lipoxygenase Alox15. J Bone
Miner Res 20[suppl 1], 1140. 2005. Abstract.
Karim MA, Wang
X, Hale T, Elbein SC.
Upstream stimulatory factor 1 (USF1) gene polymorphisms are
associated with altered insulin secretion but not type 2
diabestes (T2DM) or lipid levels. Proceedings of the 65th
Scientific Session of the American Diabetes Association San
Diego, California, 1178-P. 6-10-2005. Abstract.
Karim MA, Wang
X, Hale TC, Elbein SC.
Insulin Promoter Factor 1 variation is associated with type 2
diabetes in African Americans. BMC Med Genet; 6:37, 2005.
Karim MA, Craig RL, Wang X, Hale TC,
Elbein SC. Analysis of
FOXO1A as a candidate gene for type 2 diabetes. Mol Genet Metab
2006; 88(2):171-7.
Kern PA,
Yao-Borengasser A, Rasouli N, Reue K.
Adipose tissue lipin expression is decreased in insulin
resistance and increased by pioglitazone. Proceedings of the
65th Scientific Session of the American Diabetes Association San
Diego, California, 1424-P. 6-10-2005. Abstract.
Kern PA, Rasouli N. The pathogenesis
and treatment of high-risk obesity. In: Fonseca V, editor.
Clinical Diabetes. Philadelphia, PA: Saunders; 2006.
Kern PA.
Adipose tissue gene
expression in the context of inflammation and obesity. In: Meskin MS, editor. Phytochemicals: Nutrient-gene interactions.
Boca Raton: CRC Taylor & Francis; 2006. p. 83-96.
Kohli M, Viswamitraa S, Schaefer R,
Faas FH, Kumar U.
Metastasectomy for isolated bilateral adrenal metastases in
hormone-refractory prostate cancer. Clin Adv Hematol Oncol
2006; 4(10):754-5.
Kousteni S,
Almeida M, Han L, Warren A, Lowe V,
Manolagas SC. Estrogens
control the birth and apoptosis of bone cells in mice in which
ERa
cannot interact with DNA (ERaNERKI/-).
J Bone Miner Res 20[suppl 1], 1098. 2005.
Kousteni S, Almeida M, Han L,
Bellido T, Jilka RL, Manolagas SC. Opposing effects of kinase-initiated
versus classical genotropic actionsof the estrogen receptor on
osteoblast commitment and differentiation in vitro and in vivo.
J Bone Miner Res 2006; 21[Suppl 1], S5. Abstract.
Kousteni S, Almeida M, Han L, Warren
A, Lowe V, Manolagas SC. Estrogens control the birth and
apoptosis of bone cells in mice in which ERa
cannot interact with DNA (ERaNERKI/-).
The Endocrine Society's 88th Annual Meeting. Boston,
Massachusetts. 2006 June 24. Abstract.
Kousteni S, Almeida M, Han L, Bellido T, Jilka RL,
Manolagas SC. Induction of osteoblast differentiation
by selective activation of kinase-mediated actions of the
estrogen receptor. Mol Cell Biol 2007; 27(4):1516-30.
Kumar J, Kumar
A, Das SK, Shukla G,
Sengupta S. Detection of differential gene copy number using
denaturing high performance liquid chromatography. J Biochem
Biophys Methods; 64(3):226-34, 2005.
Kumar J,
Das SK, Sharma P,
Karthikeyan G, Ramakrishnan L, Sengupta S. Homocysteine levels
are associated with MTHFR A1298C polymorphism in Indian
population. J Hum Genet 2005; 50(12):655-63.
Makdissi A, Ioachimescu AG,
Mandarino LJ, et al.
Free fatty acids-induced insulin
resistance in healthy subjects uncouples nitric oxide synthase
pathway via arginine deficiency.
Diabetes 2006; 55: A157-A158 Suppl. 1. Abstract.
Malhotra A,
Elbein SC, Ng MC, Duggirala R,
Arya R, Imperatore G, Adeyemo A, Pollin TI, Hsueh WC, Chan JC,
Rotimi C, Hanson RL, Hasstedt SJ, Wolford JK. Meta-analysis of
genome-wide linkage studies of quantitative lipid traits in
families ascertained for type 2 diabetes. Diabetes 2007;
56(3):890-6.
Manolagas SC.
Pathogenesis of fractures in glucocorticoid-induced
osteoporosis. Straub N, editor. 4-13. 2005. New Jersey,
Excerpta Medica, an Elsevier business. Treatment and prevention
of osteoporosis: An Opportunity Missed?
Manolagas SC,
Almeida M, Han L, Weinstein RS, Jilka RL,
Bellido T, O'Brien CA, Kousteni S.
Decreased defense against reactive oxygen species: a common
pathogenetic mechanism of the effects of aging and estrogen
deficiency on bone. J Bone Miner Res 20[suppl 1], F401.
2005. Abstract.
Manolagas
SC, Jilka RL, Kousteni S,
Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L.
Response to Windahl et al. J Clin Invest 2006; 116(11):2834.
McCarthy MI,
Zeggini E, Rayner W, Groves CJ, Hanson RL, Damcott C, Pollin TI,
Vaxillaire M, Jia W, Knowler WC, Baier LJ, Froguel P, Xiang K,
Cardon L, Bogardus C, Deloukas P,
Elbein SC, Alan R. Variation within the
hyperlipidaemia susceptibility gene, USF1, does not explain
1q-encoded susceptibility to Type 2 Diabetes. Proceedings of the
65th Scientific Session of the American Diabetes Association San
Diego, California, 134-OR. 6-10-2005. Abstract.
Mehta JL,
Rasouli, N, Sinha AK, Molavi
B. Oxidative stress in diabetes: a
mechanistic overview of its effects on parthenogenesis and
myocardial dysfunction. Int J Biochem Cell Biol 2006;
38(5-6):794-803.
Molavi B,
Rasouli N, Kern PA. The prevention and treatment of
metabolic syndrome and high-risk obesity. Curr Opin Cardiol
2006; 21(5):479-85.
Nesmith JD, Spencer HJ, III, Harris
MM, Barrett KW, Kern PA, Elbein SC. Racial
differences in
metabolic syndrome prevalence and correlates among overweight
adolescents. The American Diabetes Association 67th Scientific
Sessions. Chicago, Illinois. 2007 June 22-26; 1864-P.
Abstract.
O'Brien CA,
Fu Q, Plotkin LI, Bellido T,
Goellner JJ, Jilka RL, Weinstein RS,
Manolagas SC. Transgenic expression o fthe diphtheria
toxin receptor, otherwise known as heparin-binding EGF-like
growth factor, in osteoblasts and osteocytes reduces bone mass
and strength. J Bone Miner Res 20[suppl 1], F289. 2005.
Abstract.
O'Brien CA,
Jilka RL, Fu Q, Stewart S,
Weinstein RS, Manolagas SC.
IL-6 is not required for parathyroid hormone stimulation of
RANKL expression, osteoclast formation, and bone loss in mice.
Am J Physiol Endocrinol Metab; 289(5):E784-E793, 2005.
O'Brien CA, Fu Q, Mommsen L, Dusevich V, Bonewald L,
Manolagas SC, Jilka RL. Osteoblasts are
not the source of RANKL and OPG in bone but are required for
maintenance of osteoclast function. J Bone Miner Res 2006;
21[Suppl 1]: S31. Abstract.
O'Brien CA, Plotkin L, Vyas K, Cazer
PE, Gortazar AR, Goellner JJ, Chen J, Shelton R,
Weinstein RS, Schipani E,
Jilka RL, Manolagas SC, Bellido T. Activation of PTH
receptor 1 specifically in osteocytes suppresses Sost expression
and increases bone mass in transgenic mice. J Bone Miner Res
2006; 21[Suppl 1]: S4. Abstract.
O'Brien CA, Plotkin L, Vyas K, Galli
C, Cazer PE, Gortazar AR, Goellner JJ, Shelton R,
Weinstein RS, Schipani E, Glatt V, Bouxsein ML,
Jilka RL, Manolagas SC,
Bellido T. Activation of PTH Receptor 1 Specifically in
Osteocytes Suppresses Sost Expression and Increases Bone Mass in
Transgenic Mice. The Endocrine Society's 89th Annual Meeting.
Toronto, Canada. 2007 June 2-5; OR3-1. Abstract.
Owens RJ,
Ono F, Paulson DR, Rasouli N,
Kern PA. A balanced increase in all isoforms of
adiponectin occurs following pioglitazone-mediated reduction in
muscle lipid and improvement in insulin sensitivity. Proceedings
of the 65th Scientific Session of the American Diabetes
Association San Diego, California, 1430-P. 6-10-2005. Abstract.
Owen KR, Groves CJ, Hanson RL,
Knowler WC, Shuldiner AR, Elbein SC,
et al. and the International Type 2 Diabetes 1q Consortium.
Common variation in the LMNA gene (encoding Lamin A/C) and type
2 diabetes: association analyses in 9518 subjects. Diabetes
2007;56(3):879-83.
Parfitt AM.
Weight of normal parathyroid glands in patients with parathyroid
adenomas. J Clin Endocrinol Metab 2005; 90(1):595.
Parfitt AM.
Vitamin D and the pathogenesis of rickets and osteomalacia. In:
Feldman D, Glorieux F, Pike W, editors. Vitamin D. 2nd
ed. San Diego, CA: Academic Press, Inc.; 2005. p. 1029-45.
Parfitt AM,
Weinstein RS, Bellido T, Jilka RL,
O'Brien CA, Kousteni S, Stewart SA, Roberson
P, Manolagas SC. Age-related
loss of bone strength in the spine and hindlimb of mice
independently of BMD. J Bone Miner Res 20[suppl 1], SU019. 2005.
Abstract.
Parfitt AM.
Modeling and remodeling: how bone cells work together. In:
Feldman D, Glorieux F, Pike W, editors. Vitamin D. 2nd
ed. San Diego, CA: Academic Press, Inc.; 2005. p. 497-513.
Parfitt AM.
Vitamin D and the pathogenesis of rickets and osteomalacia. In:
Feldman D, Glorieux F, Pike W, editors. Vitamin D. 2nd
ed. San Diego, CA: Academic Press, Inc.; 2005. p. 1029-45.
Parfitt AM. Misconceptions V –
Activation of osteoclasts is the first step in the bone
remodeling cycle. Bone 2006; 39:1170-1172.
Parfitt AM.
Regulation or
Permission? Journal of Bone Mineral Research 2007;
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Rani D,
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The American Diabetes Association 66th Scientific
Sessions. Washington DC. 2006 June 9-22: 1371-P. Abstract.
Yao-Borengasser A, Varma V, Bodles
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American Diabetes Association 67th Scientific Sessions. Chicago,
Illinois. 2007 June 22-26:1406-P. Abstract.
Yao-Borengasser A, Varma V, Bodles
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tissue of humans. The American Diabetes Association 67th
Scientific Sessions. Chicago, Illinois. 2007 June 22-26:
1390-P. Abstract.
Zeggini E, Damcott CM, Hanson RL,
Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley
AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC,
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diabetes in samples from populations with replicated evidence of
linkage to chromosome 1q. Diabetes 2006; 55(9):2541-8.
Zeggini E, Rayner W, Hanson R,
Groves G, Mitchell B, O’Connell J, Vaxillaire M, Jia W, Ng M,
Knowler W, Baier L, Xiang K, Chan J, Froguel P, Cardon I,
Bogardus C, Shuldiner A, Deloukas P, Elbein S, Mccarthy M, for
the International 1q Type 2 Diabetes Consortium. Large-Scale
Association Studies To Identify Diabetes-Susceptibility Loci on
Chromosome 1q: The Importance of Stringent Quality Control The
American Diabetes Association 66th Scientific
Sessions. Washington DC. 2006 June 9-22: 1137-P. Abstract.
Zeggini E, Rayner W, Hanson R,
Groves G, Mitchell B, O’Connell J, Vaxillaire M, Jia W, Ng M,
Knowler W, Baier L, Xiang K, Chan J, Froguel P, Cardon I,
Bogardus C, Shuldiner A, Deloukas P, Elbein S, Mccarthy M, for
the International 1q Type 2 Diabetes Consortium. Replicated
Association between Type 2 Diabetes and Variants in CAPON
Revealed by High Density Linkage Disequilibrium Mapping on
Chromosome 1q. The American Diabetes Association 66th
Scientific Sessions. Washington DC. 2006 June 9-22: 354-OR.
Abstract.
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