Yuzhi Chen, PhD
Neural stem cells
are present in the adult central nervous system of all mammals,
including humans. These stem cells hold great potential for the
treatment of disorders such as neurodegenerative diseases and stroke.
We are interested in understanding the function of neddylation during
stem cell development from proliferation to differentiation and cell
fate determination. We hope to identify the components of the
neddylation pathway that may differentially regulate stem cell
development into neuronal cell types or tumorgenic cells. Another
focus of this project is to understand how environmental factors such as
inflammatory factors, hypoxia, and UV irradiation will influence stem
cell proliferation and differentiation.
analysis of hippocampal stem cells isolated from adult mice.
These progenitor cells are positive for nestin, a core intermediate
filament protein essential for proper cytoskeletal formation during
neurogenesis. In this culture, some cells also express the astrocyte