The CTN was established in 2003, as a division of the Department of Neurobiology
& Developmental Sciences. Edgar Garcia-Rill, PhD, was appointed as the Director
of the CTN. The purpose of the CTN is to facilitate and integrate research on
translational aspects of neuroscience across UAMS, basically bringing basic
neuroscience findings to the bedside. Through the IDeA program at NIGMS, we
obtained a Center of Biomedical Research Excellence (COBRE) award, and have been
funded for the last 10 years.
The CTN is also the research arm of the Jackson T. Stephens Spine & Neuroscience
Institute. The Director of the Spine Institute is T. Glenn Pait, MD, who is also
Clinical Director of the CTN. A highlight of this program is the Spinal Cord
Injury Mobilization Program designed to provide the most comprehensive therapy
program for recovery of movement. Two patented devices developed at UAMS form
part of this program.
Other advances at the CTN during the last 10 years include, a) the development
of a novel treatment for tinnitus that is effective in a significant (but not
all) number of patients, b) the development of a novel treatment for spatial
neglect that eliminates the deficit after a few days, c) the development of a
promising new treatment for spasticity, d) the discovery of a novel mechanism
for sleep-wake control that promises to revolutionize the sleep field and
provide new avenues in the field of anesthesia, and e) the development of a
telemedicine program in neonatology that provides education and consultation to
underserved areas that decreased newborn mortality across the entire State.
During that time, we have generated over $32 million in new grants for our
investigators and published over 400 articles and chapters that would not have
been possible without CTN support. Our goal of bringing clinician scientists
back into translational research is beginning to have a significant impact on
the health of our citizens. We are now in Phase III of our COBRE and provide
services through our Core Facilities and pilot study funding to CTN
to know how to establish a successful translational research program? See our
"Translational Neuroscience: guide to a successful translational
is authored by Edgar Garcia-Rill, PhD, published by Wiley-Blackwell,
describes the steps necessary to design and implement a Center for
Translational Research like the CTN.
to know how to controls waking in health and disease? See our book: "Waking
and the Reticular Activating System in Health and Disease",
is authored by Edgar Garcia-Rill, PhD, published by Academic Press
in 2015, and describes research over the past 35 years, all directed
at this system. There are few if any books that deal with waking
proper. The simple act of waking and staying awake is not so simple.
And it is very hard work, as we will see. The unseen hand of the
Reticular Activating System guides our lives, promotes our survival,
and gives us identity.
Watch a 7-minute video of recent successes:"Brain