Education:
PhD
University of California , Riverside , 1985 MS
University of California , Davis , 1982
BS
University of Arkansas , 1976
Research Interest :
Toxicology of the respiratory, reproductive, and immune systems; Drug and chemical metabolism; Human health risk assessment; Pesticide toxicology.
Selected Publications:
Imamura, T., J. Gandy, T.R. Fukuto and P. Talbot. 1983. An impurity of malathion alters the morphology of rat lung bronchiolar epithelium. Toxicology 26 :73-79.
Imamura, T., L. Hasegawa, J. Gandy and T.R. Fukuto. 1983. Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats. Chemico.-Biol. Interact., 45 :53-64.
Imamura, T., J. Gandy and T.R. Fukuto. 1983. Selective inhibition of rat pulmonary monooxygenase by O,O,S-trimethyl phosphorothioate treatment. Biochem. Pharmacol. 32 :3191-3195.
Gandy, J., P. Talbot, T.R. Fukuto and T. Imamura. 1983. Phenobarbital pretreament protects against morphological changes in rat bronchiolar epithelium caused by an impurity of malathion. Amer. J. Pathol. 111 :350-353.
Gandy, J., T.R. Fukuto and T. Imamura. 1984. Sequential and dose-dependent morphological alterations in the rat bronchiolar epithelium during O,O,S-trimethyl phosphorothioate induced delayed toxicity. J. Pathol. 143 :127-137.
Gandy, J., F.A.F. Ali, L. Hasegawa and T. Imamura. 1984. Morphological alteration of rat lung bronchiolar epithelium produced by various trialkyl phosphorothioates. Toxicology 32 :37-46.
Imamura, T., J. Gandy and L, Hasegawa. 1985. Development of tolerance to a pneumotoxic impurity of malathion. J. Toxicol. Environ. Health., 15 :279-291.
Gandy, J. and T. Imamura. 1985. Cellular responses to O,O,S-trimethyl phosphorothioate-induced pulmonary injury in rats. Toxicol. Appl. Pharmacol., 80 :51-57
Gandy, J., C.M. Teaf, F.A. Adatsi, R.C. James and R.D. Harbison. 1987. The dependence of male reproductive toxicity on germ cell stage. In: Functional Teratogenesis: Functional Effects on the Offspring After Parental Drug Exposure, T. Fuji and P.M. Adams (Eds.), Teikyo University Press, Tokyo, Japan, pg 133-143.
Gandy, J. and T. Imamura. 1987. A phosphorothionate isomer protects against the pneumotoxicity caused by O,O,S-trimethyl phosphorothioate. Toxicol. Appl. Pharmacol. 87 :498-508.
Kerger, B.D., J. Gandy, T.J. Bucci, S.M. Roberts, R.D. Harbison and R.C. James. 1988. Antagonism of bromobenzene-induced hepatotoxicity by the alpha adrenergic blocking agents, phentolamine and idazoxan. Toxicol. Appl. Pharmacol., 95 :12-23.
Imamura, T. and J. Gandy. 1988. Pulmonary toxicity of phosphorothioate impurities found in organophosphate insecticides. Pharmacol. Ther., 38 :419-427.
Kerger, B.D., S.M. Roberts, J.A. Hinson, J. Gandy, R.D. Harbison and R.C. James. 1988. Antagonism of bromobenzene-induced hepatotoxicity by phentolamine: evidence for a metabolism independent intervention. Toxicol. Appl. Pharmacol., 95 :24-31.
Durham , S.K., J. Gandy and T. Imamura. 1988. Atrophine pretreatment does not abrogate O,O,S-trimethyl phosphorothiate-induced bronchiolar injury in mice. Toxicol. Pathology, 16 :392-395.
Harbison, R.D., C.C. Conaway, L.F. Rubin and J. Gandy. 1989. A study of chronic morpholine exposure in rats. Fund. Appl. Toxicol., 12 :491-507.
Barnett, J. B. and J. Gandy. 1989. Effect of acute exposure on the immune response of C57Bl/6 mice. Fund. Appl. Toxicol., 12 :757-764.
Mattison, D.R., D.R. Plowchalk, M.J. Meadows, A.Z. Al-Jubure, J. Gandy and A. Malek. 1990. Reproductive toxicity: the male and female reproductive systems as targets for chemical injury. Med. Clinics N. Am., 74 :391-411.
Gandy, J., G.C. Millner, H.K. Bates, D.A. Casciano, and R.D. Harbison. 1990. The effects of selected chemicals on the glutathione status of the male reproductive system of rats. J. Toxicol. Eviron. Health, 29 :45-57.
Barnett, J.B., B.L. Blaylock, J. Gandy, J.H. Menna, R. Denton and L.S.F. Soderberg. 1990. Long-term alteration of adult bone marrow colony-formation by prenatal chlordane exposure. Fund. Appl. Toxicol., 14 :688-695.
Blaylock, B.L., L.S.F. Soderberg, J. Gandy, J.H. Menna, R. Denton, and J.B.Barnett. 1990. Cytotoxic T Lymphocyte and NK responses in mice treated prenatally with chlordane. Toxicol. Lett., 51 :41-49.
Seng, J.E., J.E. Leakey, M.P. Arlotto, A. Parkinson and J. Gandy. 1991. Cellular localization of cytochrome P450llA1 in testes of mature Sprague-Dawley rats. Biol. Reproduction, 45 :867-882.
Barnett, J.B., J. Gandy, D. Wilbourn and S.A. Theus. 1992. Comparison of the immunotoxicity of propanil and its metabolite, 3,4-dichloroaniline, in C57B1/6 mice. Fund. Appl. Toxicol., 18 :628-631.
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