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Education:
Post Doc
9/02–9/05 Postdoctoral Fellow, Department of Environmental Sciences and
Engineering, The University of North Carolina at Chapel Hill
PhD
1/96–5/02 Chemistry, Department of Chemistry University of Kaiserslautern
Germany, and University of Minnesota cancer Center, Minneapolis, MN
MS
8/94-9/96 Biology,
University of Kaiserslautern, and The German Cancer Research Center,
Heidelberg, Germany
Research
Interest :
I am interested in understanding the interplay between
chemical exposure and nutritional or lifestyle habits, such as diet
selection and physical activity. To achieve this we utilize DNA and
protein adducts to study carcinogen metabolism, how it is modified by
nutritional components and the underlying mechanisms regulating
corresponding enzyme activities. In addition studies investigate
exposures related changes in common metabolic pathways, using targeted
and un- targeted mass spectrometry based metabolomic approaches.
Selected
Publications:
1.
Swenberg,J.A., Fryar-Tita,E., Jeong,Y.C., Boysen,G., Starr,T.,
Walker,V.E., and Albertini,R.J. (2008) Biomarkers in Toxicology and Risk
Assessment: Informing Critical Dose-Response Relationships. Chem Res
Toxicol, 21, 253-265.
2.
Esther,C.R., Jr., Jasin,H.M., Collins,L.B., Swenberg,J.A., and
Boysen,G. (2008) A mass spectrometric method to simultaneously
measure a biomarker and dilution marker in exhaled breath condensate.
Rapid Commun.Mass Spectrom, 22, 701-705.
3.
Boysen,G.,
Georgieva,N.I., Upton,P.B., Walker,V.E., and Swenberg,J.A. (2007)
N-terminal globin adducts as biomarkers for formation of butadiene
derived epoxides. Chem Biol Interact., 166, 84-92.
4.
Boysen,G.,
Scarlett,C.O., Temple,B., Combs,T.P., Brooks,N.L., Borchers,C.H., and
Swenberg,J.A. (2007) Identification of covalent modifications in P450
2E1 by 1,2-epoxy-3-butene in vitro. Chem Biol Interact., 166, 170-175.
5.
Georgieva,N.I., Boysen,G., Upton,P.B., Jayaraj,K., Gold,A., and
Swenberg,J.A. (2007) Quantitative analysis of N-terminal valine peptide
adducts specific for 1,2-epoxy-3-butene. Chem.Biol.Interact., 166,
219-225.
6.
Swenberg,J.A., Boysen,G., Georgieva,N., Bird,M.G., and lewis,R.J.
(2007) Future directions in butadiene risk assessment and the role of
cross-species internal dosimetry. Chem Biol Interact., 166, 78-83.
7.
Albertini,R.J., Sram,R.J., Vacek,P.M., Lynch,J., Rossner,P., Nicklas,J.A.,
McDonald,J.D., Boysen,G., Georgieva,N., and Swenberg,J.A. (2007)
Molecular epidemiological studies in 1,3-butadiene exposed Czech
workers: female-male comparisons. Chem.Biol.Interact., 166, 63-77.
8.
Powell,C.L., Kosyk,O., Ross,P.K., Schoonhoven,R., Boysen,G.,
Swenberg,J.A., Heinloth,A.N., Boorman,G.A., Cunningham,M.L., Paules,R.S.,
and Rusyn,I. (2006) Phenotypic anchoring of acetaminophen-induced
oxidative stress with gene expression profiles in rat liver. Toxicol.Sci,
93, 213-222.
9.
Swenberg J.A., Boysen,G., and Gorgeiva,N. (2004) The use of
biomarkers to understand butadiene carcinogenesis. Toxicol.Pathol., 32,
733-735.
10.
Boysen,G.,
Georgieva,N.I., Upton,P.B., Jayaraj,K., Li,Y., Walker,V.E., and
Swenberg,J.A. (2004) Analysis of diepoxide-specific cyclic N-terminal
globin adducts in mice and rats after inhalation exposure to
1,3-butadiene. Cancer Research, 64, 8517-8520.
11.
Boysen,G.,
Kenney,P.M., Upadhyaya,P., Wang,M., and Hecht,S.S. (2003) Effects of
benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene
and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344
rats. Carcinogenesis, 24, 517-525.
12.
Boysen,G.
and Hecht,S.S. (2003) Analysis of DNA and protein adducts of
benzo[a]pyrene in human tissues using structure-specific methods.
Mutat.Res., 543, 17-30.
PubMed listed Publications
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