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Dr. Zheng received her PhD degree in Molecular Endocrinology from Department of Biology, University of Alabama at Birmingham (UAB). She received her postdoctoral training at the Center for Heart Failure Research, Department of Medicine at UAB.
Dr. Zheng is a Research Instructor in the Department of Pharmaceutical Sciences at the University of Arkansas for Medical Sciences (UAMS), and is a member of the Division of Radiation Health in the College of Pharmacy.
Dr. Zheng’s research focuses on how stimulation of mast cells in response to radiation contributes to intestinal inflammation and/or fibrosis by activating protease activated receptors 2(PAR2). Her expertise also includes using high-information content microarrays to study the regulation of mast cells on intestinal gene expression and injury at acute and late radiation injury in wild type and mast cell deficient rats.
Recent Publications
1. Ulasova E, Gladden JD, Chen Y, Zheng J, Pat B, Bradley W, Powell P, Zmijewski JW, Zelickson BR, Ballinger SW, Darley-Usmar V, Dell'italia LJ. Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload. J Mol Cell Cardiol. 2011 Jan;50(1):147-56. PMID:21059354
2. Pat B, Chen Y, Killingsworth C, Gladden JD, Shi K, Zheng J, Powell PC, Walcott G, Ahmed MI, Gupta H, Desai R, Wei CC, Hase N, Kobayashi T, Sabri A, Granzier H, Denney T, Tillson M, Dillon AR, Husain A, Dell'italia LJ. Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation. Circulation. 2010 Oct 12;122(15):1488-95. PMID:20876440
3. Zheng J, Chen Y, Pat B, Dell'italia LA, Tillson M, Dillon AR, Powell PC, Shi K, Shah N, Denney T, Husain A, Dell'Italia LJ. Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog. Circulation. 2009 Apr 21;119(15):2086-95. PMID:20691651
4. Zheng J, Chen HY, Choi CY, Roer RD, Watson RD. Molecular cloning of a putative crustacean hyperglycemic hormone (CHH) isoform from extra-eyestalk tissue of the blue crab (Callinectes sapidus), and determination of temporal and spatial patterns of CHH gene expression. Gen Comp Endocrinol. 2010 Nov 1;169(2):174-81. PMID: . PMID:20691651
5. Zheng J, Nakatsuji T, Roer RD, Watson RD. Studies of a receptor guanylyl cyclase cloned from Y-organs of the blue crab (Callinectes sapidus), and its possible functional link to ecdysteroidogenesis. Gen Comp Endocrinol. 2008 Feb 1;155(3):780-8. PMID:18093588
6. Zheng J, Lee CY, Watson RD. Molecular cloning of a putative receptor guanylyl cyclase from Y-organs of the blue crab, Callinectes sapidus. Gen Comp Endocrinol. 2006 May 1;146(3):329-36. PMID:16006046 |
Junying Zheng, Ph.D