Rupak Pathak, Ph.D
Research Instructor
Division of Radiation Health
Department of Pharmaceutical Sciences
UAMS College of Pharmacy
Winthrop P. Rockefeller Cancer Institute

E-mail address: rpathak@uams.edu
Phone: 501-526-6990 Ext. 8375
Fax:501-686-6517

1. Dr. Pathak received his Ph.D. in Radiation Biology from Kalyani University (Kalyani, West Bengal, India).  He served as Assistant Professor in the Radiobiology Department of Manipal University (Manipal, Mangalore, Karnataka, India).  He received postdoctoral training at the Armed Forces Radiobiology Research Institute (Bethesda, MD, USA).
   
   
2. Dr. Pathak is a Research Instructor of Pharmaceutical Sciences at the University of Arkansas for Medical Sciences (UAMS), member of the Division of Radiation Health in the College of Pharmacy.
   
   
3. Dr. Pathak’s research focuses on low- and high-LET (such as 7Li, 12C and 16O-beam) radiation induced cytogenetic alterations in mammalian cells and understanding the molecular mechanisms of cell death after exposure to both radiation types.  His expertise also includes radiation bio-dosimetry and radiation countermeasure.  His current research goal is to develop radiation countermeasures that can be used in the event of accidental or incidental radiation mass casualty and find out the molecular basis of radiation protection.
   

Recent Publications

1.

Rupak Pathak, A. R. Khuda Bukhsh, S. K. Dey, U. Ghosh, B. Sen Gupta, M. Semwal, N. P. Bhattacharyya, 2007, Resistance to induction of micronuclei, chromosomal aberrations and apoptosis by 60Co g- ray in a cell strain M5, derived from Chinese hamster V79 cells. Journal of Radio-analytical and Nuclear Chemistry, 274, 441-447.

2.

Rupak Pathak, Subrata Kumar Dey Asiti Sarma and Anisur Rahman Khuda-Bukhsh, 2007, Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to 7Li-beam (LET = 60 keV/mm) and correlation of their survival dynamics to nuclear damages and cell death. Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 628, 56-66. PMID: 17258499

3.

R. Pathak, A. Sarma, B. Sengupta, S.K. Dey, A.R. Khuda-Bukhsh, 2007, Response to high LET radiation 12C (LET, 295 keV/mm) in M5 cells, a radio resistant cell strain derived from Chinese hamster V79 cells. International Journal of Radiation Biology, 83, 53-63. PMID: 17357440

4.

R. Pathak, S.K. Dey, A. Sarma, A.R. Khuda-Bukhsh, 2007, Cell killing, nuclear damage and apoptosis in Chinese hamster V79 cells after irradiation with heavy-ion beams of 16O, 12C and 7Li. Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 632, 58-68. PMID: 17532254

5.

Choudhry, P.R., Pandit, B., Pathak, R., Chaudhuri, K., Bhattacharyya, N.P., 2008, Increased expression of genes in a radio-resistant cell strain: modulation of hnRNP E2, Hsp90, and SSBP2 genes in γ-irradiated Chinese hamster V79 cells. International Journal of Low Radiation, 4, 313-331.

6.

Rupak Pathak, Adarsh Ramakumar, Uma Subramanian and Pataje GS Prasanna, 2009, Differential radio-sensitivities of human chromosomes 1 and 2 in one donor in interphase- and metaphase–spreads after 60Co γ-irradiation. BMC Medical Physics, 9, 6. PMID: 19531236

7.

Rerbee M, Fu Q, Boerma M, Pathak R, Zhou D, Kumar KS, Hauer-Jensen M, 2010, Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin. Int. J. Radiation Oncology Biol. Phys. 79, 884-891 PMID: 20950957