Shi J. Liu, B.S., M.S., Ph.D.
Professor
Department of Pharmaceutical Sciences
Phone: (501) 686-8106
Email:liushi@uams.edu

Education & Training
B.S. (Zoology, 1976) at National Taiwan Normal Univeristy,
Taipei, Taiwan, R.O.C.
M.S. (Physiology, 1978) at National Taiwan University, College of Medicine, Taipei, Taiwan, R.O.C.
Ph.D., Duke University

Teaching Responsibilities
Doctoral Dissertation

Research & Scholarly Interests
My research interest are to 1) investigate alterations in ion transport mechanisms of cardiac cell function (particularly related to E-C coupling) in response to physiological, pharmacological and pathophysiological conditions (e.g., aging, drug actions, inflammation), 2) characterize signaling pathways responsible for these conditions, and 3) understand cellular mechanisms for cell survival and cell death so to develop drugs to improve function of cardiac cells and prevent the growth of breast cancer cells

Honors & Awards
Invited Seminar: Modulation of cardiac L-type Ca channel current by cytokines. 1998.

American Health Assistant Foundation: National Heart Association. San Diego, CA.

Memberships
American Physiology Society

Publications
Yu, X-W, RH Kennedy and SJ Liu (2003). JAK2/STAT3, not ERK1/2, Pathway Mediates Interleukin-6-elicited Inducible NOS Activation and Negative Inotropic Effect in Adult Ventricular Myocytes. Journal of Biological Chemistry 278: 16304-16309.

Yu, X-W, Q Chen, RH Kennedy and SJ Liu (2005). Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. Journal of Physiology (London) 566.2: 327-340.

Yu, X-W, MeeiYueh G Liu, RH Kennedy and SJ Liu (2005). Both cGMP and peroxynitrite mediate chronic interleukin-6-induced negative inotropy in adult ventricular myocytes. Journal of Physiology (London) 566.2: 341-353.

JiaXuan Zhu, MeeiYueh Liu, Richard H. Kennedy and Shi J. Liu (2006). TNF-a-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes. Cytokine 34:96-105.

Daniel SD Liu, Chad E. Krebs and Shi J. Liu (2007). The role of PKC-a in cytotoxicity induced by anticancer drugs in MCF-7 breast cancer cells. Journal of Cellular Biochemistry 101:517-528.

Shi J. Liu (2007). Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes. American Journal of Physiology 293:C1594-C1604.