Degrees

B.S., M.S., National University of Mexico
Ph.D., University of Illinois at Chicago

Research Interests

My research interests include elucidation of the mechanism of action of drugs, clarification of the relationships between the physicochemical properties of compounds and their activity, function, or role; and drug design. Our work relies on the use of various molecular modeling techniques, structure-activity relationships (SAR) analysis methods, and biochemical procedures. Recent projects that we have studied include the mechanisms of mutagenicity of nitroaromatic compounds, mechanism of oxidation of retinoic acid; structure-function relationships of Cytochrome P450 reductase, NAD(P)H:quinone reductase, and heat-shock protein 70; and SAR of substance P analogues ligands to NK1 receptor.

Recent Publications

1. Compadre RL, Byrd C and Compadre CM. Comparative QSAR and 3D-QSAR analysis of the mutagenicity of organic compounds. Principles of QSAR and Drug Design, James Devillers, editor, Taylor and Francis, pp. 111-136, 1998.
2. Fan M, Byrd C, Compadre CM and Compadre RL. Comparison of CoMFA models for S. typhimurium TA98, TA100, TA+S9, and TA100+S9 mutagenicites of nitroaromatic compounds. SAR and QSAR in Environmental Research, 9:187-215, 1998.
3. Samokyszn VM, Chang HC and Compadre RL. A theoretical investigation of endocyclic allylic carbon-centered radical formation in retinoic acid. Bioorganic and Medicinal Chemistry Letters, 7:2343-2348, 1997.

E-mail Address: CompadreRosaL@uams.edu