Departments and Programs
>>Pharmaceutical Sciences

Faculty

Research Interests:
Exciting challenges exist in the development of high-throughput analytical techniques capable of addressing problems identified by recent advances in the areas of pharmaceutical and drug discovery research. In general, we concern ourselves with improving the speed of analysis beginning with sampling process and ending with the data analysis. Our primary goal is to develop a general approach to analytical methods development that is based the physical and chemical properties of drug candidates. We bring a variety of techniques and technologies together to achieve these goals including the use of modern extraction techniques, high performance analytical separation. Mass spectrometry, fluorescence, and amperometric detection are used in conjunction with chromatography to improve sensitivity and increase selectivity.

Teaching:
Pharmaceutics
Pharmaceutical Biotechnology

Recent Publications:

Eric C Peterson, Elizabeth M Laurenzana, William T Atchley, Howard P Hendrickson, and S. Michael Owens, Development and Preclinical Testing of a High Affinity Single Chain Antibody against (+)-Methamphetamine J. Pharm Exp. Therap. Published January 11, 2008; doi: 10.1124/jpet.107.134395
 

Lindsay Naef, Lalit Srivastava, Alain Gratton, Howard Hendrickson, S. Michael Owens and Claire-Dominique Walker, Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration, Psychopharmacology, 2007. 10.1007/s00213-007-1008-4.
 

Howard P. Hendrickson, Elizabeth M. Laurenzana, and S. Michael Owens. Quantitative Determination Of Total Methamphetamine And Active Metabolites In Rat Tissue By Liquid Chromatography With Tandem Mass Spectrometric Detection. The AAPS Journal, 2006 8(4), E709 – E717.
 

Alessandra Milesi-Hallé, Howard P. Hendrickson, Elizabeth M. Laurenzana, W. Brooks Gentry and S. Michael Owens. Sex- and Dose-Dependency in the Pharmacokinetics and Pharmacodynamics of (+)-Methamphetamine and its Metabolite (+)-Amphetamine in Sprague-Dawley Rats. Toxicology and Applied Pharmacology, 2005 209, 203-213.

Howard P. Hendrickson, E. Catherine Whaley, and S. Michael Owens; A validated liquid chromatography/tandem mass spectrometric method for the determination of phencyclidine in micro liter samples of rat serum. Journal of Mass Spectrometry, 2005, 40, 19-24.

W. Brooks Gentry, Abid U. Ghafoor, William D. Wessinger^, Elizabeth M. Laurenzana, Howard P. Hendrickson, and S. Michael Owens; (+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration. Pharmacology, Biochemistry and Behavior, 2004, 79, 751 – 760.

Howard P. Hendrickson, A. Milesi-Halle, E.M. Laurenzana, and S.M. Owens; Development and validation of an LC/MS/MS method for pharmacokinetics of (+)-methamphetamine and (+)-amphetamine. Journal of Chromatography B, 2004, 806, 81 – 87.
 

Howard P. Hendrickson, Bill J. Gurley, and William D. Wessinger; Determination of dextromethorphan and its metabolites in micro liter serum samples by liquid-liquid extraction and liquid chromatography with fluorescence detection. Journal of Chromatography B, 2003, 788, 261 – 268.
 

Muldrew Kenneth L, James Laura P, Coop Leslie, McCullough Sandra S, Irwin Lisa W, Hendrickson Howard P, Mayeux Philip R, Hinson Jack, A; Determination of acetaminophen-protein adducts in mouse liver ands serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection, Drug Metabolism and Disposition, 2002, 30, 446-451.