Employment

Associate Professor, Graduate School of Pharmaceutical Sciences Osaka University

Chief, Division of Cell Biology, Department of Bioscience, National Cardiovascular Center Research Institute

Academic Awards

The Okamoto Young Investigator’s Award (Japan Vascular Disease Research Foundation) (2000)

Young Investigator’s Award (Japanese Biochemical Society) (2000)

Young Investigator’s Award (Japanese Pharmacological Society) (2001)

Li, L., Sawamura, T. and Renier, G.: Glucose enhances human macrophage LOX-1 expression. Role for LOX-1 in glucose-induced macrophage foam cell formation. Circ Res, 94:892-901, 2004.

Smirnova, I., Kajstura, M., Sawamura, T. and Goligorsky, M.: Asymmetric dimethylarginine upregulates Lox-1 in activated macrophages: The role in foam cell formation. Am J Physiol Heart Circ Physiol, 287:782-790, 2004.

Smirnova, I., Sawamura, T. and Goligorsky, M.: Upregulation of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency. Am J Physiol Renal Physiol, 287:25-32, 2004.

Pavan, L., Hermouet, A., Tsatsaris, V., Therond, P., Sawamura, T., Evain-Brion, D. and Fournier, T.: Lipids from oxidized-LDL modulate human trophoblast invasion: involvement of LXR nuclear receptors. Endocrinology, 145:4583-4591, 2004.

Honjo, M., Sawamura, T., Hinagata, J., Nakamura, K., Sanada, N., Tanihara, H., Honda, Y. and Kiryu, J.: Expression of LOX-1, an oxidized low-density lipoprotein receptor, in choroidal neovascularization. Arch Ophthalmol, 122:1873-1876, 2004.

Kakinuma, T., Yasuda, T., Nakagawa, T., Hiramitsu, T., Akiyoshi, M., Akagi, M., Sawamura, T. and Nakamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Arthritis Rheum, 50:3495-3503, 2004.

Imanishi, T., Hano, T., Sawamura, T. and Nishio, I.: Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol, 31:407-413, 2004.

Li, L., Roumeliotis, N., Sawamura, T. and Renier, G.: C-reactive protein enhances LOX-1 expression in human aortic endothelial cells. Relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction. Circ Res, 95:877-883, 2004.

Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H. and Hamanishi, C.: Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB. Osteoarthritis Cartilage, 12:568-576, 2004.

Suga, M., Sawamura, T., Nakatani, T., Kitamura, S.: Expression of lectin-like oxidized low-density lipoprotein receptor-1 in allografted hearts. Transplant Proc, 36: 2440-2442, 2004.

Kashiwakura, Y., Watanabe, M., Kusumi, N., Sumiyoshi, K., Nasu, Y., Yamada, H., Sawamura, T., Kumon, H., Takei, K. and Daida, H.: Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. Circulation, 110:3329-3334, 2004.

Sakurai, K., Cominacini, L., Garbin, U., Pasini, A. F., Sasaki, N., Takuwa, Y., Masaki, T., Sawamura, T.: Induction of endolthelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor LOX-1. J. Cardiovasc Pharmacol, 44:S173-S180, 2004.

Pasini, A. F., Garbin, U., Nava, M. C., Stranieri, C., Davoli, A., Sawamura, T., Cascio, V. L., Cominacini, L.: Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens, 23:589-96, 2005.

Puccetti, L., Sawamura, T., Pasqui, A. L., Pastorelli, M., Auteri, A., Bruni, F.: Atorvastatin reduces platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients. Eur J Clin Invest, 35:47-51, 2005.

Theriault, J.R., Mambula, S.S., Sawamura, T., Stevenson, M.A. and Calderwood, S.K.: Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells. FEBS Lett, 579:1951-1960, 2005.

Limor, R., Kaplan, M., Sawamura, T., Sharon, O., Keidar, S., Weisinger, G., Knoll, E., Naidich, M. and Stern, N.: Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway. Am J Hypertens, 18:299-307, 2005.

Chen, M. and Sawamura, T.: Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). J Mol Cell Cardiol, in press, 2005.

Inoue, K., Arai, Y., Kurihara, H., Kita, T. and Sawamura, T.: Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res, in press, 2005.