Nolan Professor and Chair, Department of Internal Medicine

EDUCATION

1970  A.B. Degree, Harvard University, Cambridge, MA
1974   M.D. Degree, Harvard Medical School, Boston, MA

TRAINING

1974‑1977  Intern to Senior Resident Physician, Peter Bent Brigham Hospital, Boston, MA
1974‑1977  Clinical Fellow in Medicine, Harvard Medical School, Boston, MA
1976-1977  Chief Medical Resident, West Roxbury Veterans Administration Hospital, West Roxbury, MA
1977‑1978   Research/Clinical Fellow in Medicine, Peter Bent Brigham Hospital, Boston, MA
1977‑1980   Research Fellow in Medicine, Harvard Medical School, Boston, MA
 

AWARDS AND HONORS
1970  Magna Cum Laude, Harvard University
1973  Annual Award for outstanding research by a student, AFCR Eastern Section
1973  Alpha Omega Alpha
1980  Clinical Investigator Award, National Institutes of Health
1988  First International Lecturer, Tokyo Heart Society
1992-2000  Editorial Board, Circulation Research
1994-present  Editorial Board, Heart Failure Reviews
1995  Invited Lecturer, American College of Cardiology - MI Affiliate, annual meeting
1998 Invited Lecturer, American Heart Association Midwest Consortium Scientific Sessions
1998-2002  Editorial Board, Journal of the American College of Cardiology
1988  College Teaching Award, Wayne State University School of Medicine
1999-present  Editorial Board, Journal of Molecular and Cellular Cardiology
1999-2000  Molecular and Cellular Biology Study Section, Great America Consortium, American Heart Association
2000  Association of University Cardiologists
2001  Fellow of the American Heart Association
2001 -2004  Chair, Cardiovascular and Thrombosis Subcommittee, Pharmacy and Therapeutics Committee, Detroit Medical Center
2002  Featured Speaker, American Heart Association Michigan Affiliate Scientific Sessions
2002  Elected to Detroit Academy of Medicine
2002  College Teaching Award, Wayne State University School of Medicine
2004  Residents’ Outstanding Teacher Award, Wayne State University
2005  Editorial Board, American Journal of Medicine
2005, 2006, 2007  Best Doctors in America List, Cardiovascular Disease Category

MAJOR PROFESSIONAL SOCIETIES
1980 Clinical Council, American Heart Association
1981 Fellow, American College of Cardiology
1982 American Federation for Clinical Research
1982 Fellow, American College of Physicians
1983 Basic Science Council, American Heart Association
1984 International Society for Heart Research
1985 American Society for Pharmacology and Experimental Therapeutics
1986 Biophysical Society
1993 American Physiological Society
1998 Association of Professors of Cardiology
2000 Association of University Cardiologists
2003 Member, Department of Surgery Chair Search Committee, WSU
2004 Chair, Cancer Center Search Committee, UAMS
2004 Association of Professors of Medicine
2005 Management Committee, Arkansas Cancer Research Center
2006  Southern Society for Clinical Investigation
2007 American Clinical and Climatological Association

CLINICAL AND RESEARCH INTERESTS
Coronary heart disease; Congestive heart failure; Arrhythmias; Stroke prevention; Cardiac cell biology; Cardiac contractile function; Clinical cerebrovascular disease

RECENT RESEARCH
2002-2004  WARCEF Study. NIH. PI: Patrick Pulicino, University of New Jersey, James D. Marsh, member of Executive Committee. Total annual direct cost: approx. $4,000,000. Also, Site PI: James D. Marsh MD. Annual direct cost approx. $60,000.

2000-2005 “Regulation of calcium channel expression.”Veterans Administration Merit Award, $150,000 Annual direct cost. PI: James D. Marsh MD.

2000-2006 Veterans Administration REAP Award. Marsh PI:, Project 2: Insulin and regulation of calcium channel transcription. Total annual direct cost $750,000.

2001-2005 “Mechanisms of arrhythmia suppression by exercise training.”NIH. PI: H. Collins, PhD, Mentor: James D. Marsh, MD. Annual direct cost $100,000.

2001-2005 “Modulation of excitation-contraction coupling by androgens.”Veterans Administration Type II Merit Award. PI: Kish Golden, PhD. Mentor: James D. Marsh, MD. Annual direct cost $75,000.

CURRENT RESEARCH
2004-2008 “CaV1.2 transcript regulation in heart and smooth muscle.”NIH 1R01-HL073097-01A1 PI: Phillip Palade PhD.; Annual direct cost $250,000. Subcontract: James D. Marsh annual direct cost: $50,000.

2004-2008 “In vitro assessment of risk of drug-induced arrhythmias.”NIH. R41. R. Parchment, PI. James D. Marsh, MD, Co-investigator. Annual direct cost $71,500.

2004-2009 “Role of calsequestrin and its phosphorylation in heart.”NIH 5R01-HL62586 Steven Cala: PI, James D. Marsh, Consultant Annual direct cost $250,000.

2007-2009 American Heart Association. “Gene-based calcium channel modulation.” Total Direct Costs: $65,000. PI, James Marsh.

Pending Grants
2006-2011   "Disruption of Ca²⁺ Channels and Impact on Vascular Tone.”PI, James D. Marsh (Project 4 in Program Project Grant: Vascular Smooth Muscle Calcium signaling in Hypertension - Nancy Rusch, Principal Investigator). NIH.

RECENT SELECTED PUBLICATIONS
Fan QI, Vanderpool K, Marsh JD. A 27 bp cis-acting sequence is essential for L-type calcium channel alpha 1C subunit expression in vascular smooth muscle cells. Biochem Biophys Acta 1577(3):401-11, 2002.

Golden KL, Marsh JD, Jiang Y. Castration reduces mRNA levels for calcium regulatory proteins in rat heart. Endocrine 19(3):339-344, 2002.

Fan QI, Vanderpool K, O’Connor J, Marsh JD. Decoy calcium channel beta subunits modulate contractile function in myocytes. Mol Cell Biochem 242:3-10, 2003.

Vouyouka AG, Salib SS, Cala S, Marsh JD, Basson MD. Chronic high pressure potentiates the antiproliferative effect and abolishes contractile phenotypic changes caused by endothelial cells in cocultured smooth muscle cells. J Surg Res 110(2):344-51, 2003.

Golden KL, Marsh JD, Jiang Y, Brown T, Moulden J. Gonadectomy of adult male rats reduces contractility of isolated cardiac myocytes. Am J Physiol Endocrinol Metab 285:E449-E453, 2003.

Kher N, Marsh JD. Pathobiology of atherosclerosis- a brief review. Seminars in Thrombosis and Hemostasis 30: 665-672, 2004.

Raja Golden KL, Marsh JD, Jiang Y, Moulden J. Gonadectomy alters myosin heavy chain composition in isolated cardiac myocytes. Endocrine 24(2):137-40, 2004.

Golden KL, Marsh JD, Jiang Y. Testosterone regulates mRNA levels of calcium regulatory proteins in cardiac myocytes. Horm Metab Res 36(4):197-202, 2004.

Ram ML, Kiarash A, Marsh JD, Cala SE. Phosphorylation and dephosphorylation of calsequestrin on CK2-sensitive sites in heart. Mol Cell Biochem 266:209-217, 2004.

Li H, Télémaque S, Miller RE, Marsh JD. High Glucose Inhibits Apoptosis Induced by Serum Deprivation In Vascular Smooth Muscle Cells Via Upregulation of Bcl-2 and Bc1-xl. Diabetes 54(2):540-5, 2005.

Fan QI, Vanderpool KM, Chung H-S, Marsh JD. The L-type calcium channel alpha 1C subunit undergoes extensive, uncoordinated alternative splicing. Mol Cell Biochem 269(1-2); 153-63, 2005.

Golden KL, Marsh JD, Jiang Y, Moulden J. Acute actions of testosterone on contractile function of isolated rat ventricular myocytes. Eur J of  Endocrinol 152(3):470-83, 2005.

Chen X, Zhang X, Kubo H, Harris DM, Mills GD, Moyer J, Berretta R, Vanderpool K, Telemaque Potts S, Marsh JD, Houser SR. Ca²⁺ influx induced sarcoplasmic reticulum Ca²⁺ overload causes mitochondrial dependent apoptosis in ventricular myocytes. Circulation Research 97:1009-1017, 2005.

Rajamani K, Sunbulli M, Jacobs BS, Berlow E, Marsh JD, Kronenberg M,  McLaughlin P, Vouyouka A, Levine SR, Lai Z, Chaturvedi S. Detection of carotid stenosis in African Americans with ischemic heart disease. Journal of Vascular Surgery 43(6):1162-65, 2006.

Sonkusare S, Palade PT, Marsh JD, Télémaque S, Pesic A, Rusch NJ.  Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implications. Vascular Pharmacology 44:131-142, 2006.

Sonkusare S, Stimers J.R., Grain T., Marsh JD, Telemaque S. Expression of a b2 subunit mutant alters Ca currents in HL-1 cells: FASEB J 20:(5, Part II) A1114, 2006.

Sonkusare S, Fraer M, Marsh JD, Rusch N. Disrupting calcium channel expression to lower blood pressure: new targeting of a well-known channel. Molecular Therapeutics 2006; 6 (6)304-10.

Milstein ML, McFarland TP, Marsh JD, Cala S. Inefficient glycosylation leads to high steady-state levels of actively degrading cardiac triadin-1. Journal of Biological Chemistry 2008; 283(4):1929-35.

Telemaque S, Sonkusare S, Grain T, Rhee SW, Stimers JR, Rusch NJ, Marsh JD. Design of mutant subunits as decoy molecules to reduce the expression of functional CA2+ channels in cardiac cells. Journal of Pharmacology and Experimental Therapeutics 2008; 325 (1): 37-46.

Nassief A, Marsh JD. Statin Therapy for Stroke Prevention. Stroke 2008; 39(3):1042-1048.

Marsh JD, and (by invitation: Telemaque S, Rhee SW, Stimers JR, Rusch NJ). Delivery of ion channel genes to treat cardiovascular diseases. Transactions of the American Clinical and Climatological Association (in press 2008).

Ramappa P, Thatai D, Coplin W, Gellman S, Carhuapoma JR, Quah R, Atkinson B, Marsh JD. Cardiac Troponin-I: A predictor of prognosis in subarachnoid hemorrhage. Journal of Neurocritical Care 2008; 8: 398-403.