Stebbins Chair in Cardiology
Professor of Internal Medicine, Physiology and Biophysics
Director, Division of Cardiovascular Medicine
Education
MD, Punjab University, India, 1969
PhD, University of Uppsala, Sweden, 1989
Training
Residency, Mt. Sinai School of Medicine, New York, 1973
Fellowship, State University of New York, Stony Brook, 1975
Research Fellowship, University of Minnesota, Minneapolis, 1976
Honors
Visiting Professor, University of California, San Francisco, CA, January 16, 2002.
Visiting Professor, Cardiology and Pharmacology, Tulane University School of Medicine, New Orleans, LA, January 18, 2002.
Invited Lecturer, 2nd International Symposium, CAD in the New Millennium, Rome, Italy, June 3, 2002.
Invited Lecturer, 8th World Congress on Heart Failure, Washington, DC, USA, July 13-16, 2002.
Visiting Professor, Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO, October 11, 2002.
Invited speaker, Annual Session of the American Heart Association, Chicago, IL, November, 2002.
Invited speaker at the First Italian-US CME Conference, Rome, Italy. December 4-5, 2002.
Albert Fleckenstein Memorial Award for Distinguished Contributions in Basic Research in Cardiology, World Congress of Heart Disease, July 13, 2003.
Member, Editorial Board: Circulation, Hypertension, and Journal of Molecular and Cellular Cardiology.
Clinical/Research Interests
Acute cardiac care.
Molecular biology of angiotensin and ox-LDL receptors in myocardial ischemia and atherosclerosis.
Inter-regulatory role of platelets, endothelium and leukocytes in CAD.
Research Grants
National American Heart Association, mentored Scientist Development Award “Molecular mechanism of action of Ox-LDL in endothelial cells to DY Li, MD, PhD.
Department of Veteran Affairs Merit Review. Merit Review Award for project “Platelets and Reperfusion Injury”. 10/01/99 – 9/30/03
Department of Veteran Affairs Merit Review. Merit Review Award for project “The role of TGFbeta in reperfusion injury”. 10/01/03 – 9/30/08
Recent Publications
Mehta JL, Li D, Chen HJ. Protection of myocytes from hypoxia-reoxygenation injury by nitric oxide is mediated by modulation of TCF-. Circulation, 2002;105:2206-11.
Mehta JL, Li D. Identification, regulation and function of LOX-1, a novel receptor for ox-LDL. JACC, 2002;39:1429-35.
Li D, Chen HJ, Romeo F, Sawamura T, Saldeen T, Mehta JL. Statins modulate ox-LDL-mediated adhesion molecular expression in human coronary artery endothelial cells: Role of LOX-1. Journal of Pharmacology and Experimental Therapeutics, 2002; 302:601-5.
Li D, Williams V, Liu L, Chen H, Sawamura, T, Antakli T, Mehta JL. LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP1 and inflammation. American Journal of Physiology, 2002;283:H1795-801.
Li D, Williams V, Liu L, Chen H, Romeo F, Sawamura T, Mehta JL. Expression of LOX-1 during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction. JACC, 2003;41:1048-55.
Li D, Singh RM, Liu L, Singh BK, Chen H, Kazzaz N, Mehta JL. Oxidized-LDL through LOX-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cells. Cardiovascular Research, 2003;57:238-43.
Zhang W, Shokeen M, Li D, Mehta JL. Identification of apoptosis-inducing factor in human coronary artery endothelial cells. BBRC, 2003;301:147-51.
Li D, Liu L, Chen HJ, Sawamura T, Ranganathan, Mehta JL. LOX-1 mediates ox-LDL-induced expression of matrix metalloproteinase in human coronary artery endothelial cells. Circulation, 2003;107:612-17.
Chen H, Saldeen T, Li D, Mehta JL. TGF- attenuates myocardial ischemia-reperfusion injury via inhibition of upregulation of MMP-1. American Journal of Physiology, 2003;284:H1612-17.
Li D, Liu L, Chen HJ, Sawamura T, Mehta JL. LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Arteriosclerosis Thrombosis and Vascular Biology, 2003;23:816-21.
Chen HJ, Li D, Roberts GJ, Saldeen T, J.L. Mehta. Eicosapentaenoic acid inhibits hypoxia-reoxygenation-induced injury by attenuating upregulation of MMP-1 in adult rat myocytes. Cardiovascular Research, 2003;59:7-13.
Chen HJ, Li D, Roberts GJ, Saldeen T, J.L. Mehta. EPA and DHA attenuate Ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via pretein kinase B pathway. Journal of Molecular and Cellular Cardiology, 2003;35:769-75.
Books Edited
Platelets and Prostaglandins in Cardiovascular Disease, J.L. Mehta and P. Mehta, Editors; Futura Publishing Company, Mount Kisco, NY (1981)
Thrombosis and Platelets in Myocardial Ischemia, J.L. Mehta, Editor; F.A. Davis, Philadelphia, PA (1987).
Inflammatory and Infectious Basis of Atherosclerosis, J.L. Mehta, Editor; Bioscience Birkhauser Verlag AG, Basel, Switzerland (2001).