Institutional Biosafety Committee
Institutional Biosafety Committee

Purpose and Function
The Institutional Biosafety Committee (IBC) purpose is to review and evaluate investigator-generated safety protocols for the proposed use of biohazardous agents. Based on this review, the Institutional Biosafety Committee (IBC) shall approve or disapprove the safety protocols with periodic reports to the Safety Coordinating Committee. In addition, the Biosafety Committee shall make recommendations to the Safety Coordinating Committee regarding biohazards that may exist or arise on the UAMS campus.

Organization and Responsibility
The IBC shall be composed primarily of research personnel with appropriate expertise in infectious agents, toxicology, recombinant DNA, animals, and/or human gene therapy. In accordance with NIH/CDC guidelines, membership of the IBC should also include the Director of Occupational Health & Safety (Campus Safety Officer) and two members who represent the interests of the community at large. The committee members and its chairman shall be appointed by the Chancellor. The committee chairman, or his/her designee, shall be empowered to sign for the committee to approve biohazard safety protocols on appropriate institutional forms. The committee shall meet at least quarterly or as called.

Biohazardous Agents Shall Include:

  • Infectious agents at biosafety level-2 (BL-2) or higher, including bacteria, viruses, mycotic agents, parasites, prions, and virus-shedding tumor cells
  • Highly toxic compounds
  • DNA recombination involving BL-2 or higher organisms or genes
  • Gene therapy of humans (whether or not the rDNA reagent is generated at UAMS). Under the NIH Guidelines, Institutional Review Board approval of such human gene transfer clinical trials is contingent upon IBC approval.
  • Reviews the operating performance and SOPs of each newly constructed or remodeled Biosafety Level 3 (BSL3) laboratory before the laboratory opens for use.

Responsibilities of the Principal Investigator (Laboratory Supervisor) include:

Principal investigators proposing the use of biohazardous agents shall formulate safety protocols, as requested by the Biosafety Committee, detailing special procedures for the safe handling, storage, and disposal of such agents and other requested information. It is the responsibility of the principal investigator to ensure that laboratory personnel, including Animal Research Facility personnel, if appropriate, are so informed.

  • Develops a risk assessment for each project to determine the containment requirements for each proposed project, to set the required biological safety level of the project, and to establish conditions with which the investigator must comply to conduct the activity.
  • Sets policy for the acquisition and safe handling, transfer, and storage of biohazardous agents and materials and recombinant DNA constructs.

Membership
Membership consists of two community members, a non-doctoral member, the Biosafety Officer, and other members with expertise in biosafety, animal science, virology, bacteriology, pathology, and (human) gene therapy. Membership and qualifications are in compliance with Sections IV-B-2-a and IV-B-2-b of the NIH Guidelines. Ad hoc members may be called upon for specific expertise. The membership term is 3 years and membership may be renewed. The UAMS Chancellor may limit or extend the terms as needed.

Nominations to the Institutional Biosafety Committee (IBC) are solicited by the committee. Appointment to the committee is made through the Chancellor's Office. The IBC Chair is appointed by the Chancellor.

Contacts
IBC Chairman: Daniel E. Voth, Ph.D., Associate Professor, Department of Microbiology and Immunology
Biosafety Officer: James Bishop
Director of OH&S: Carol Price, MS., CHSP

Forms, Manuals, and Policies
IBC Protocol Form: Infectious Agents, Recombinant DNA, and Highly Toxic Materials Protocol
Additional information can be found on the OH&S Biological Safety Division web page.

Regulations/Guidelines

  1. NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules, Department of Health & Humans Services, National Institutes of Health.
  2. Biosafety in Microbiological and Biomedical Laboratories, 5th Edition, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institutes of Health, HHS Publication No. (CDC) 21-1112.

Submission and Meeting Schedule
Proposals to use biological agents in research may be submitted to the Institutional Biosafety Committee. Proposals should be received by the last Friday of the month to be considered at the next IBC meeting.