Robert J. Griffin, PhD
Associate Professor of Radiation OncologyDoctoral Degree
University of Minnesota, Minneapolis, Biophysical Sciences
Postdoctoral Training
University of Minnesota, Minneapolis, Radiobiology
E-mail Phone
rjgriffin@uams.edu
501-526-7873
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Research Interests:
Biology and physiology of thermal therapy; molecular and physiological mechanisms of radiation and thermal sensitization; modulation of tumor blood flow, angiogenesis and oxygenation; and oxygen partial pressure as a predictor of cancer treatment process.
Research Overview:
Robert J. Griffin, Ph.D. is an Associate Professor and Radiation Biologist in the Department of Radiation Oncology at UAMS. He graduated with a Ph.D. in Biophysical Sciences from the University of Minnesota. He has been involved as a postdoctoral associate and then faculty member in the Department of Therapeutic Radiology-Radiation Oncology at the University of Minnesota since 1998. He was also a graduate faculty member in the Biophysical Sciences and Medical Physics program.
Dr. Griffin has been first author on 12 published peer-reviewed articles and collaborated on 43 other publications. His research interests include: biology and physiology of thermal therapy; molecular and physiological mechanisms of radiation and thermal sensitization; modulation of tumor blood flow, angiogenesis and oxygenation; and oxygen partial pressure as a predictor of cancer treatment process.
Currently Dr. Griffin is PI on two R01 grants from NIH/National Cancer Institute (NCI)-one funded and one undergoing competitive renewal. In addition, he is funded by the Central Arkansas Radiation Therapy Institute for a study aimed at understanding the biology and physiology of breast cancer metastasis to bone and to develop better treatment strategies with vascular-targeted agents in combination with radiation therapy. He also is or has been a co-investigator on four other NIH/NCI funded projects and several industry-supported research projects. Cell Therapeutics, Inc. funded a two year research project to determine optimal dosing and scheduling of the clinically used arsenic compound, Trisenox with radiation therapy. Since 2004 he has been a grant reviewer for the U.S. Army Breast Cancer Research Program, Radiation Oncology study section and is a manuscript peer reviewer on four national/international journals.
A few national organizations that Dr. Griffin is a member of are: American Association for Cancer Research (AACR); Society for Thermal Medicine; Radiation Research Society; and American Society for Therapeutic Radiology and Oncology (ASTRO).
Selected Publications: |
Visaria RK, Bischof JC,
Williams BW, Ebbini ES, Griffin RJ: Nanotherapeutics for thermal
therapy enhancement. Submitted, International Journal of Hyperthermia,
2007.
Farooqui M, Li Y-F, Rogers
T, Poonawala T Griffin RJ, Song CW, Gupta K: Cox-2 inhibitor
celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumor
growth, metastasis and mortality, without compromising analgesia.
Submitted, Clin Can Res, 2007.
Dings RPMD, Heun H,
Griffioen AW, Mayo KM, Griffin RJ: Scheduling of radiation with
angiogenesis inhibitors Avastin and Anginex improves therapeutic outcome via
vessel normalization. Clin Cancer Res 13(11):3395-402, 2007.
Choi EK, Terai K, Ji IM,
Kook, YH, Park KH, Oh ET, Griffin RJ, Park HJ et al.:
Radiation-induced up-regulation of NAD(P)H:Quinone Oxidoreductase (NQO1)
potentiates the effect of bioreductive β-lapachone against cancer cells.
In press, Mol Can Ther, 2007.
Lee BW, Olin MR, Johnson
GL, Griffin RJ: In vitro and in vivo apoptosis detection using
membrane permeant, fluorescent labeled inhibitors of caspases. In press,
Humana Press, October 2007.
Amano M, Suzuki M, Andoh
S, Monzen H, Terai K, Williams BW, Song CW, Mayo KM, Hasegawa T, Dings RPM,
Griffin RJ: Antiangiogenesis therapy using a novel angiogenesis
inhibitor, anginex, following radiation causes tumor growth delay. Int J
Clin Oncology, 12: 42-47, 2007.
Arerangaiah R, Chalasani
N, Udager AM, Manivel JC, Griffin RJ, Song CW, Gupta K: Opioids
Induce Renal Abnormalities in Tumor Bearing Mice.
Nephron Exp Nephrol., 105(3): 80-9, 2007.
Griffin, RJ:
Book Review, Radiobiology for the Radiologist, 6th Ed. Int J Rad
Onc Bio Phys 66(2): 627, 2006.
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