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Donald M. Mock, M.D., Ph.D.
Professor and
Research Subject Advocate for the UAMS/VA General Clinical Research Center
M.D., University of Texas Health Science Center, Southwestern Medical School
Board certified in
Pediatrics and Pediatric Gastroenterology
Ph.D.
University of Texas Health Science Center,
Southwestern Medical School
M.S., Stanford University
B.S., Baylor University
Areas of current Research Interest
Nutrition of Biotin-
Incidence of biotin deficiency in pregnancy and potential role of biotin
deficiency in human teratogenesis; biotin metabolism, particularly degradation
and regulation of degradation of biotin; mechanism and regulation of cellular
uptake including inborn errors of biotin transport; role of biotin in
biotinylation of histones and their potential role on DNA replication or
transcription.
Non-radioactive measurement
of red cell mass and red cell survival.
Biotinylation of low
molecular peptides hormones such as erythropoietin and subsequent quantitation
in order to study pharmacokinetics of endogenously secreted erythropoietin and
potentially other hormones.
Selected Publications
Mock, D.M.,
N. I. Mock, C. Stewart, J. B. LaBorde, D. K.Hansen: Marginal biotin deficiency
is teratogenic in ICR mice. J Nutr, in press, (2003).
[Abstract]
Strauss, R.G., D.M. Mock,
K. Johnson, N. Mock, G. Cress, L. Knosp, L. Lobas, R Schmidt: Circulating red
blood cell (RBC) volume, measured using biotinylated RBCs, is superior to the
hematocrit to document the hematologic effects of delayed versus immediate
umbilical cord clamping in preterm neonates. Transfusion, 50: (2003), in
press.
Stanley, J.S., D.M. Mock,
J.B. Griffin, J. Zempleni: Biotin uptake into human peripheral blood mononuclear
cells increases early in the cell cycle, increasing carboxylase activities. J
Nutr, 132 (7):1854-1859, (2002).
[Abstract]
Mock, D.M.,
N.I. Mock: Lymphocyte propionyl-CoA carboxylase activity is an early and
sensitive indicator of biotin deficiency in the rat, but urinary excretion of
3-hydroxypropionic acid is not. J Nutr, 132: 1945-1950, (2002).
[Abstract]
Mock, D.M.,
C.L. Henrich, N.S. Carnell, N.I. Mock, L. Swift: Lymphocyte propionyl-CoA
carboxylase and accumulation of odd-chain fatty acid in plasma and erythrocytes
are useful indicators of marginal biotin deficiency. J Nutr Biochem, 13
(8); 462-470, (2002).
Mock, D.M.,
C.L. Henrich, N.S. Carnell, N.I. Mock: Indicators of marginal biotin deficiency
and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a
leucine challenge. Am J Clin Nutr, 76 (5):1061-8, (2002).
[Abstract]
Mardach, R., J. Zempleni, B.
Wolf, S. Cress, J. Boylan, S. Roth, S. Cederbaum, D. M. Mock: Biotin
dependency due to a defect in biotin transport. J Clin Invest,
109:1617-1623, (2002).
[Abstract]
Mock, D.M.,
J.R. Quirk, N.I. Mock: Biotin deficiency during normal pregnancy. Am J Clin
Nutr, 75:295-299, (2002). [Abstract]
Helm R.M., N.I. Mock, P.
Simpson, D.M. Mock: Certain immune markers are not good indicators of
mild to moderate biotin deficiency in rats. J Nutr, 131(12), 3231-3236,
(2001).
[Abstract]
Mock, D.M.,
E.F. Bell, G.L. Lankford, J.A. Widness: Hematocrit correlates well with red cell
volume in very low birth weight infants. Pediatr Res 50(4), 525-531,
(2001).
[Abstract]
Mock, D.M.,
J. Nyalala, R. M. Raguseo: A direct streptavidin-binding assay does not
accurately quantitate biotin in human urine. J Nutr 131(8), 2208-2214,
(2001).
[Abstract]
Zempleni, J., J.S. Stanley,
D.M. Mock: Proliferation of peripheral blood mononuclear cells causes
increased expression of the sodium-dependent multivitamin transporter gene and
increased uptake of pantothenic acid. J Nutr Biochem, 12(8), 465-473,
(2001). [Abstract]
Zempleni, J., R.M. Helm,
D.M. Mock: In vivo biotin supplementation at a pharmacologic dose
decreases proliferation rates of human peripheral blood mononuclear cells and
cytokine release. J Nutr, 131(5), 1479 –1484, (2001).
[Abstract]
Mock, D.M., K-S
Wang, G.L. Kearns: The clearance and metabolism of biotin administered
intravenously to pigs at tracer and physiologic amounts is much more rapid than
previously appreciated. J Nutr, 131(4), 1271 - 1278, (2001).
[Abstract]
Pubmed link to additional publications
Reviews and Chapters in Books/Proceedings (selected from a total
of 31):
1) Bogusiewicz
A and Mock, D. Biotin-Protein Bond: Instability and Structural
Modification to Provide Stability for in vivo Applications. In: Methods in
Molecular Biology
In press due (2007).
2) Mock
D. Biotin, In: B. Rucker, J. Suttie, D. McCormick, and L. Machlin (eds.),
Handbook of Vitamins . 4th edition. CRC Press LLC. in press, due
January (2007).
3) Sealey
W, Mock D. Biotin. In: Lange R., Wilbertz H., (eds.) Enclyopedic Reference of
Molecular Mechanisms of Disease. Heidelberg: Springer-Verlag, in press, due
September (2007).
4) Mock
D. Biotin. In: Coates P, ed. Encyclopedia of Dietary Supplements: Marcel
Dekker, Inc, 31 - 40, (2005).
5) Mock
D. Biotin: Physiology, dietary sources and requirements. In: Encyclopedia of
Human Nutrition. 2nd Ed. Caballero B, Allen L, Prentice A, (eds.), England:
Elsevier Press, Ltd., 201 - 209, (2005).
6) Mock,
D.M.: Biotin In: Modern Nutrition in Health and Disease. 10th Ed, Shils,
M.E., Shike, M., Ross, A.C., Caballero, B., Weinsier, R.L., Cousins, R.J.
(eds.), Lippincott Williams & Wilkens, Baltimore, 498 - 506, (2005).
7) Zempleni
J., and Mock, D.M. (2001). 102: Biotin (b) Physiology. In: The Encyclopaedia of
Food Sciences and Nutrition 2nd Ed. Vol 1, B Caballero, L. Trugo, and P.
Finglas, (eds.), London: Academic Press, Ltd.
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E-mail: |
MockDonaldM@uams.edu |
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Office: |
(501) 526-4201 |
Barton 6R08A |
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Lab:
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(501) 526-4201
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Barton 6R06/6R11 |
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FAX:
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(501)
603-1146 |
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