Donald M. Mock, M.D., Ph.D.

Professor and Research Subject Advocate for the UAMS/VA General Clinical Research Center

M.D., University of Texas Health Science Center, Southwestern Medical School
Board certified in Pediatrics and Pediatric Gastroenterology
Ph.D. University of Texas Health Science Center, Southwestern Medical School
M.S., Stanford University
B.S., Baylor University

Areas of current Research Interest

Nutrition of Biotin- Incidence of biotin deficiency in pregnancy and potential role of biotin deficiency in human teratogenesis; biotin metabolism, particularly degradation and regulation of degradation of biotin; mechanism and regulation of cellular uptake including inborn errors of biotin transport; role of biotin in biotinylation of histones and their potential role on DNA replication or transcription.

Non-radioactive measurement of red cell mass and red cell survival.

Biotinylation of low molecular peptides hormones such as erythropoietin and subsequent quantitation in order to study pharmacokinetics of endogenously secreted erythropoietin and potentially other hormones.

Selected Publications

Mock, D.M., K-S Wang, G.L. Kearns: The clearance and metabolism of biotin administered intravenously to pigs at tracer and physiologic amounts is much more rapid than previously appreciated. J Nutr, 131(4), 1271 - 1278, 2001. Abstract

Zempleni, J., R.M. Helm, D.M. Mock: In vivo biotin supplementation at a pharmacologic dose decreases proliferation rates of human peripheral blood mononuclear cells and cytokine release. J Nutr, 131(5), 1479 –1484, 2001. Abstract

Zempleni, J., J.S. Stanley, D.M. Mock: Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acid. J Nutr Biochem, 12(8), 465-473, 2001. Abstract

Mock, D.M., J. Nyalala, R. M. Raguseo: A direct streptavidin-binding assay does not accurately quantitate biotin in human urine. J Nutr 131(8), 2208-2214, 2001. Abstract

Mock, D.M., E.F. Bell, G.L. Lankford, J.A. Widness: Hematocrit correlates well with red cell volume in very low birth weight infants. Pediatr Res 50(4), 525-531, 2001. Abstract

Helm R.M., N.I. Mock, P. Simpson, D.M. Mock: Certain immune markers are not good indicators of mild to moderate biotin deficiency in rats. J Nutr, 131(12), 3231-3236, 2001. Abstract
 

Mock, D.M., J.R. Quirk, N.I. Mock: Biotin deficiency during normal pregnancy. Am J Clin Nutr, 75:295-299, 2002. Abstract

Mardach, R., J. Zempleni, B. Wolf, S. Cress, J. Boylan, S. Roth, S. Cederbaum, D. M. Mock: Biotin dependency due to a defect in biotin transport. J Clin Invest, 109:1617-1623, 2002. Abstract

Mock, D.M., C.L. Henrich, N.S. Carnell, N.I. Mock: Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. Am J Clin Nutr,  76 (5):1061-8, 2002. Abstract

Mock, D.M., C.L. Henrich, N.S. Carnell, N.I. Mock, L. Swift: Lymphocyte propionyl-CoA carboxylase and accumulation of odd-chain fatty acid in plasma and erythrocytes are useful indicators of marginal biotin deficiency. J Nutr Biochem, 13 (8); 462-470, 2002.

Mock, D.M., N.I. Mock: Lymphocyte propionyl-CoA carboxylase activity is an early and sensitive indicator of biotin deficiency in the rat, but urinary excretion of 3-hydroxypropionic acid is not. J Nutr, 132: 1945-1950, 2002. Abstract

Stanley, J.S., D.M. Mock, J.B. Griffin, J. Zempleni: Biotin uptake into human peripheral blood mononuclear cells increases early in the cell cycle, increasing carboxylase activities. J Nutr, 132 (7):1854-1859, 2002. Abstract

Strauss, R.G., D.M. Mock, K. Johnson, N. Mock, G. Cress, L. Knosp, L. Lobas, R Schmidt: Circulating red blood cell (RBC) volume, measured using biotinylated RBCs, is superior to the hematocrit to document the hematologic effects of delayed versus immediate umbilical cord clamping in preterm neonates. Transfusion, 50: 2003, in press.

Mock, D.M., N. I. Mock, C. Stewart, J. B. LaBorde, D. K.Hansen: Marginal biotin deficiency is teratogenic in ICR mice. J Nutr, in press, 2003. Abstract

Pubmed link to additional publications

Reviews and Chapters in Books/Proceedings (selected from a total of 31):

1)  Zempleni J., and Mock, D.M. 2001. 102: Biotin (b) Physiology. In: The Encyclopaedia of Food Sciences and Nutrition  2nd Ed. Vol 1, B Caballero, L. Trugo, and P. Finglas, (eds.), London: Academic Press, Ltd.

2)  Mock, D.M.: Biotin In: Modern Nutrition in Health and Disease. 10th Ed, Shils, M.E., Shike, M., Ross, A.C., Caballero, B., Weinsier, R.L., Cousins, R.J. (eds.), Lippincott Williams & Wilkens, Baltimore, 498 - 506, 2005.

3)  Mock D. Biotin: Physiology, dietary sources and requirements. In: Encyclopedia of Human Nutrition. 2nd Ed. Caballero B, Allen L, Prentice A, (eds.), England: Elsevier Press, Ltd., 201 - 209, 2005.

4)  Mock D. Biotin. In: Coates P, ed. Encyclopedia of Dietary Supplements: Marcel Dekker, Inc, 31 – 40, 2005.

5)  Sealey W, Mock D. Biotin. In: Lange R., Wilbertz H., (eds.) Enclyopedic Reference of Molecular Mechanisms of Disease. Heidelberg: Springer-Verlag, in press, due September 2007.

6)  Mock D. Biotin, In: B. Rucker, J. Suttie, D. McCormick, and L. Machlin (eds.), Handbook of Vitamins . 4^th edition. CRC Press LLC. in press, due January 2007.

7)  Bogusiewicz A and Mock, D. Biotin-Protein Bond: Instability and Structural Modification to Provide Stability for in vivo Applications. In: Methods in Molecular Biology In press due 2007.

Home Page  |  Comments and Suggestions  |  Faculty  |  Staff  |  Students 
 Seminar Schedule  |  Graduate Program  | Undergraduate Program

Department of Biochemistry and Molecular Biology
University of Arkansas for Medical Sciences
4301 W. Markham St., Slot 516
Little Rock, AR 72205