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Craig A. Cooney, Ph.D.
Assistant Professor
Ph.D, University of California,
Davis
Mammalian
Lifespan Extension and Advanced Cancer Chemotherapies
Extension of lifespan.
We study the role of epigenetics and the melanocortin 4 receptor (MC4R) on the
health and lifespan of mammals. Epigenetics and the action of the MC4R can be
changed by genes, drugs and nutrition. Our long-term goal is to greatly
increase the healthy lifespan of mice and people.
Epigenetic markers of biological age.
We study epigenetic markers that correlate with biological age. These markers
may give us accurate predictors of how long mice will live.
Maternal effects.
We were the first to change offspring epigenetics through the maternal diet in
mammals. We use these and other methods to study other maternal effects on
offspring epigenetics.
Cancer epigenetics.
We are pursuing novel, low-toxicity approaches to change cancer cell metabolism
from simple glycolysis (Warburg effect) to instead cause cancer cells to produce
acetyl-CoA from glucose and make it available for histone acetylation and
activation of tumor suppressor genes. Normal cells are expected to be largely
unaffected by the combination of low dose, low toxicity drugs used to achieve
these ends. Our long term focus is to develop treatments that eradicate at
least some cancers yet have few or no side effects for patients.
Selected Publications
Wolff GL, Kodell RL, Moore SR,
Cooney CA
(1998) Maternal Epigenetics and Methyl Supplements Affect Agouti Gene Expression
in Avy/a Mice.
FASEB Journal,
12, 949-957
Cooney CA,
Wise, CW, Poirier LA, Ali SF (1998) Methamphetamine Treatment Affects Blood and
Liver S-Adenosylmethionine (SAM) in Mice: Correlation with Dopamine Depletion in
the Striatum.
Annals of the New York Academy of
Sciences
844, 191-200
Southern F, Cruz N, Fink LN,
Cooney CA,
Barone GW, Eidt JF, Moursi MM (1998) Hyperhomocysteinemia Increases Intimal
Hyperplasia in a Rat Carotid Endarterectomy Model.
Journal of Vascular Surgery,
28, 909-918
Cooney CA
(2001) Dietary Selenium and Arsenic Affect DNA Methylation.
Journal of Nutrition
131, 1871
Cooney CA,
Dave AA, Wolff GL (2002) Maternal Methyl Supplements in Mice Affect Epigenetic
Variation and DNA Methylation of Offspring.
Journal of Nutrition
132, 2393S-2400S
Kaput J, Klein KG, Reyes EJ, Kibbe WA,
Cooney CA,
Jovanovic B, Visek WJ, Wolff GL (2004) Identification of Genes Contributing to
the Obese Yellow Avy Phenotype: Caloric Restriction, Genotype, Diet x
Genotype Interactions.
Physiological Genomics
18, 316-324.
Kurmasheva RT, Peterson CA, Parham DM, Chen B, McDonald RE,
Cooney CA
(2005) Upstream CpG Island Methylation of the PAX3 Gene in Human
Rhabdomyosarcomas.
Pediatric Blood and Cancer
44, 328-337.
Safar MA, Spencer H, Su X, Coffey M,
Cooney CA,
Ratnasinghe LD, Hutchins LF, Fan C-Y (2005) Methylation Profiling of Archived
Non-Small Cell Lung Cancer: A Promising
Prognostic System.
Clinical Cancer Research
11,
4400-4405.
Cooney CA
(2006)
Maternal Nutrition: Nutrients and
Control of Expression. in Nutrigenomics: Concepts and Technologies.
James Kaput and Raymond L. Rodriguez, editors. pp219-254 John Wiley and Sons,
Hoboken, New Jersey
C
Cooney CA
(2006) Germ Cells Carry the Epigenetic Benefits of Grandmother's Diet.
Proc Natl Acad Sci USA,
103, 17071-17072
Cooney CA
(2007) Epigenetics - DNA-based Mirror of Our Environment.
Disease Markers
23, 121-137
Xie
C-H, Naito A, Mizumachi T, Evans TT, Douglas MG, Cooney CA, Fan C-Y,
Higuchi M (2007) Mitochondrial Regulation of Cancer Associated Nuclear DNA
Methylation.
Biochem Biophys Res Commun
364, 656-61
Cooney CA
(2008) Cancer and Aging: The Epigenetic Connection. in
Cancer Epigenetics.
Trygve Tollefsbol, editor CRC Press, Boca Raton FL pp 303-316.
Leakey TI,
Zielinski J, Siegfried RN, Siegel ER, Fan C-Y, Cooney CA (2008) A simple
algorithm for quantifying DNA methylation levels on multiple independent CpG
sites in bisulfite genomic sequencing electropherograms.
Nucleic Acids Research
36, e64
Cooney CA
(2009) Nutrients, Epigenetics, and Embryonic Development. in
Nutrients and Epigenetics.
Sang Woon Choi and Simonetta Friso, editors CRC Press, Boca Raton FL pp 155-174.
Ounpraseuth S,
Rafferty TM, McDonald-Phillips RE, Gammill WM, Siegel ER, Wheeler KL, Nilsson
EA, Cooney CA (2009) A Method to Quantify Mouse Coat-Color Proportions.
PLoS ONE
4, e5414
PubMed link to additional publications
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E-mail: |
CooneyCraiga@uams.edu |
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Office: |
(501) 960-0900 Biomedical Research Center B421D |
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Lab: |
(501) 603-1004 Biomedical Research Center B416 |
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FAX: |
(501) 686-8169 |
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