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Craig A. Cooney, Ph.D.
Assistant Professor
Ph.D, University of California,
Davis
Mammalian Nutrition, DNA Regulation, Epigenetics and
Health
We study the role of DNA methylation and epigenetics on the health, cancer
development and lifespan of mammals. Epigenetics can be changed by drugs
and by specific nutrients found in foods and nutritional supplements.
Epigenetics strongly affect normal cell differentiation and cancer development.
Our interests include childhood and adult cancers that help us understand
epigenetic changes that occur with and without an aging component. We
study effects on adult animals as well as effects on offspring when their
mothers take specific supplements during pregnancy.
We also study certain molecular effects of nutrients including effects on DNA
methylation, gene expression and metabolite levels. DNA methylation is
essential for the organization, maintenance and control of chromosomes and
epigenetic regulation of the genome. We are particularly interested in
treatments and genes that will help maintain or optimize DNA methylation to
maximize longevity and prevent age-related disease.
Selected Publications
Cooney
CA, Wise, CW,
Poirier LA, Ali SF (1998) Methamphetamine Treatment Affects Blood and Liver S-Adenosylmethionine
(SAM) in Mice: Correlation with Dopamine Depletion in the Striatum. Annals New
York Academy of Sciences 844, 191-200 [Abstract]
Southern F, Cruz N, Fink
LN, Cooney CA, Barone GW, Eidt JF, Moursi MM (1998)
Hyperhomocysteinemia Increases Intimal Hyperplasia in a Rat Carotid
Endarterectomy Model. Journal of Vascular Surgery, 28, 909-918 [Abstract]
Wolff GL, Kodell RL,
Moore SR, Cooney CA (1998) Maternal Epigenetics and Methyl
Supplements Affect Agouti Gene Expression in Avy/a Mice. FASEB J., 12, 949-957 [Abstract]
Cooney CA
(2001) Dietary Selenium and Arsenic Affect DNA Methylation. J. Nutr. 131,
1871 [Abstract]
Cooney CA,
Dave AA, Wolff GL (2002) Maternal Methyl Supplements in Mice Affect Epigenetic
Variation and DNA Methylation of Offspring. J. Nutr. 132, 2393S-2400S [Abstract]
Kaput J, Klein KG, Reyes
EJ, Kibbe WA, Cooney CA, Jovanovic B, Visek WJ, Wolff GL (2004)
Identification of Genes Contributing to the Obese Yellow Avy Phenotype:
Caloric Restriction, Genotype, Diet x Genotype Interactions. Phys. Genom. 18,
316-324. [Abstract]
Kurmasheva RT, Peterson
CA, Parham DM, Chen B, McDonald RE, Cooney CA (2005) Upstream
CpG Island Methylation of the PAX3 Gene in Human Rhabdomyosarcomas.
Pediatric Blood and Cancer 44, 328-337. [Abstract]
Khaidakov M, Chavannes-Turesky
N, Cooney CA, Dupont-Versteegden EE, Kennedy R, Siegel ER,
Khaidakova G, Shmookler-Reis RJ (2005) Contribution of de novo Point Mutations
to the Overall Mutational Burden in Mitochondrial DNA of Adult Rats. Exper.
Geront. 40, 396-402. [Abstract]
Safar
MA, Spencer H, Su X, Coffey M, Cooney CA, Ratnasinghe LD,
Hutchins LF, Fan C-Y (2005) Methylation Profiling of Archived Non-Small Cell
Lung Cancer: A Promising
Prognostic System. Clinical Cancer Research 11, 4400-4405.
[Abstract]
Cooney CA (2006) Maternal Nutrition: Nutrients and
Control of Expression. in Nutrigenomics: Concepts and Technologies. James Kaput
and Raymond L. Rodriguez, editors. pp219-254 John Wiley and Sons, Hoboken, New
Jersey
Cooney CA (2006) Germ Cells Carry the Epigenetic Benefits of
Grandmother's Diet. Proc Natl Acad Sci USA, 103, 17071-17072 [Abstract]
Safar MA,
Spencer H, Su X, Cooney CA, Shwaiki A, Coke P, Fan C-Y (2007)
Promoter Hypermethylation for Molecular Nodal Staging in Non-Small Cell Lung
Cancer,
Archives of Pathology & Laboratory Medicine 131, 936-941 [Abstract]
Cooney CA (2007) Epigenetics - DNA-based Mirror of Our Environment.
Disease Markers 23, 121-137 [Abstract]
Xie C-H, Naito A, Mizumachi T, Evans TT, Douglas MG, Cooney CA,
Fan C-Y, Higuchi M Mitochondrial Regulation of Cancer Associated Nuclear
DNA Methylation. Biochemical Biophysical Research Communications in press
PubMed link to additional publications
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E-mail: |
CooneyCraiga@uams.edu |
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Office: |
(501) 960-0900 Biomedical Research Center B421D |
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Lab: |
(501) 603-1004 Biomedical
Research Center B416 |
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FAX: |
(501) 686-8169 |
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